周新文，教授，博士生导师，华中科技大学同济医学院病理生理学系， 副主任。2001年博士毕业，2004.8-2006.8，瑞典卡罗琳斯卡医学院老年痴呆研究中心，从事老年痴呆发病机制博士后研究。2014.9-2015.9，美国贝勒医学院儿童营养中心访问学者。近年获得多项国家自然基金和科技部支撑计划资助，研究方向代谢相关性痴呆的发病机制及防治，发表SCI论文三十余篇。参编五年制病理生理学教材8，9版 人民卫生出版；器官系统教材—呼吸系统与疾病；案例版病理生理学第三版 副主编。中国病理生理学杂志和微循环杂志编委。
代表性论文
Wang L#，Li N#, Shi FX, Xu WQ, Cao Y, Lei Y, Wang JZ, Tian Q,Zhou XW* Upregulation of AMPK Ameliorates Alzheimer's Disease-Like Tau Pathology and Memory Impairment. Mol Neurobiol, 2020, 57(8): 3349-3361. DOI: 10.1007/s12035-020-01955-w
Wang L#, Shi FX#; Li N; Cao Y; Lei Y; Wang JZ,Tian Q,Zhou XW* AMPK Ameliorates Tau Acetylation and Memory Impairment Through Sirt1, Mol Neurobiol, 2020，57(12):5011-5025. doi: 10.1007/s12035-020-02079-x.
Liu BJ#, Cao Y#, Shi FX, Wang L, Li N, Cheng XS, DuJ , Tian Q*, Zhou XW* The overexpression of RBM3 alleviates TBI-induced behaviour impairment and AD-like tauopathy in mice. J Cell Mol Med. 2020 Jul 10;24(16):9176-9188. doi: 10.1111/jcmm.15555
Cao Y#, Liu B#, Xu W, Wang L, Shi F, Li N, Lei Y, Wang J, Tian Q*, Zhou X*. Inhibition of mTORC1 improves STZ-induced AD-like impairments in mice Brain Res Bull. 2020;162:166-179. doi: 10.1016/j.brainresbull.2020.06.002.
Fang YY#,Zeng P# , Qu N,Ning LN, Chu J, Zhang T, Zhou XW*, Tian Q * Evidence of altered depression and dementia-related proteins in the brains of young rats after ovariectomy, J Neurochem, 2018, 146(6): 703-721.
Wang L, Shi FX, Xu WQ, Cao Y, Li N, Li M, Wang Q, Wang JZ, Tian Q, Yu LK*, Zhou XW*. The Down-Expression of ACE and IDE Exacerbates Exogenous Amyloid-β Neurotoxicity in CB2R-/- Mice. J Alzheimers Dis. 2018;64(3):957-971. doi: 10.3233/JAD-180142.
Wang L, Liu BJ, Cao Y, Xu WQ, Sun DS, Li MZ, Shi FX, Li M, Tian Q, Wang JZ, Zhou XW*. Deletion of Type-2 Cannabinoid Receptor Induces Alzheimer's Disease-Like Tau Pathology and Memory Impairment Through AMPK/GSK3β Pathway.Mol Neurobiol. 2017 Jul 17. doi: 10.1007/s12035-017-0676-2.
Liu B, Wang L, Cao Y, Xu W, Shi F, Tian Q*, Zhou X*.Hypothermia pretreatment improves cognitive impairment via enhancing synaptic plasticity in a traumatic brain injury model.Brain Res. 2017 1672:18-28.
Du LL, Wang L, Yang XF, Wang P, Li XH, Chai DM, Liu BJ, Cao Y, Xu WQ, Liu R, Tian Q, Wang JZ*,Zhou XW*.Transient Receptor Potential-canonical 1 is Essential for Environmental Enrichment-Induced Cognitive Enhancement and Neurogenesis.Mol Neurobiol.2017 54(3):1992-2002. doi: 10.1007/s12035-016-9758-9.
Du LL, Chai DM, Zhao LN, Li XH, Zhang FC, Zhang HB, Liu LB, Wu K, Liu R, Wang JZ, Zhou XW*. AMPK Activation Ameliorates Alzheimer's Disease-Like Pathology and Spatial Memory Impairment in a Streptozotocin-Induced Alzheimer's Disease Model in Rats.J Alzheimers Dis. 2015;43(3):775-784.
Li XH, Du LL, Cheng XS, Jiang X, Zhang Y, Lv BL, Liu R, Wang JZ*, Zhou XW*. Glycation exacerbates the neuronal toxicity of β-amyloid.Cell Death Dis. 2013 Jun 13;4:e673. doi: 10.1038/cddis.2013.180.
Cheng XS, Zhao KP, Jiang X, Du LL, Li XH, Ma ZW, Yao J, Luo Y, Duan DX, Wang JZ*, Zhou XW*. Nmnat2 attenuates Tau phosphorylation through activation of PP2A.J Alzheimers Dis. 2013 Jan 1;36(1):185-95.
Du LL, Xie JZ, Cheng XS, Li XH, Kong FL, Jiang X, Ma ZW, Wang JZ, Chen C, Zhou XW*. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordr). 2014 Apr;36(2):613-623.
Jiang X, Jia LW, Li XH, Cheng XS, Xie JZ, Ma ZW, Xu WJ, Liu Y, Yao Y, Du LL, Zhou XW*. Capsaicin ameliorates stress-induced Alzheimer's disease-like pathological and cognitive impairments in rats.J Alzheimers Dis. 2013 Jan 1;35(1):91-105.
Li XH, Xie JZ, Jiang X, Lv BL, Cheng XS, Du LL, Zhang JY, Wang JZ, Zhou XW*Methylglyoxal Induces Tau Hyperphosphorylation via Promoting AGEs Formation.Neuromolecular Med. 2012;14(4):338-348.
Li XH, Lv BL, Xie JZ, Liu J, Zhou XW*, Wang JZ* AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation. Neurobiol Aging 2012;33(7):1400-1410.
Yin G, Li LY, Qu M, Luo HB, Wang JZ*, Zhou XW*.Upregulation of AKT attenuates β-amyloid-induced cell apoptosis. J Alzheimers Dis. 2011;25(2):337-45.
Zhou XW, Winblad B, Guan Z, Pei JJ. Interactions Between Glycogen Synthase Kinase 3beta, Protein Kinase B, and Protein Phosphatase 2A in Tau Phosphorylation in Mouse N2a Neuroblastoma Cells. J Alzheimers Dis. 2009;17(4):929-37.
Zhou XW, Gustafsson JA, Tanila H, Bjorkdahl C, Liu R, Winblad B, Pei JJ.Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2ANeurobiol Dis. 2008;31(3):386-94.
Luo YG, Zhou XW, Yang XF, Wang JZ.Homocysteine induces Tau Hyperphosphorylation in Rats. Neuroreport. 2007 3;18(18):2005-8.
Zhou XW,Tanila H, Pei JJ. Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Aß overproduction. FEBS Lett. 2008;582(2):159-64.
Zhou XW, Li X, Bjorkdahl C, Sjogren MJ, Alafuzoff I, Soininen H, Grundke-Iqbal I, Iqbal K, Winblad B, Pei JJ. Assessments of the accumulation severities of amyloid b-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer’s brains. Neurobiology of disease 2006; 22 (3):657-668.
