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药理学系
胡壮丽

胡壮丽

个人简介:华中科技大学同济医学院药理系副教授,硕士生导师。1999年毕业于原同济医科大学临床医疗专业,获学士学位。2004-2005在美国俄亥俄州立大学心肺实验室学术交流一年,2008年获得华中科技大学博士学位。

主要方向:1. 离子通道与情感障碍性疾病;

2. 神经胶质细胞与情感障碍性疾病。

作为负责人主持课题:

①国家自然科学基金青年基金 心肌酸敏感离子通道(asics):治疗心肌缺血的新靶点(no. 30901804);

②国家自然科学基金面上基金 酸敏感离子通道(asics):小胶质细胞炎症免疫反应的重要调节蛋白(no. 81173071);

③湖北省科技研究与开发计划项目 作用于多靶点神经保护药物的合作研发(2011bfa006);

④华中科技大学自主创新基金重点专项项目 酸敏感离子通道在抑郁症中的作用机制探讨:小胶质细胞功能失调(3104710)

代表性论文:

①. rui-li liu, qiu-ju xiong, qing shu, wen-ning wu, jin cheng, hui fu, fang wang, jian-guo chen, zhuang-li hu (通讯作者). hyperoside protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via nitric oxide signal pathway. brain res. 2012 aug 21; 1469:164-73.

②. zhuang-li hu, chao huang, hui fu, you jin, wen-ning wu, qiu-ju xiong, na xie, li-hong long, jian-guo chen and fang wang. pick1 disruption attenuates both functions of asics and regulations of pkc on asics. am j physiol cell physiol. 2010 dec; 299(6):c1355-62. (sci, if=4.013)

③. qiu-ju xiong, zhuang-li hu(并列第一作者), peng-fei wu, lan ni, zhi-fang deng, wen-ning wu, jian-guo chen, fang wang. acid-sensing ion channels contribute to the increase in vesicular release from sh-sy5y cells stimulated by extracellular protons. am j physiol cell physiol. 2012 aug; 303(4):c376-84.

④. chao huang, zhuang-li hu(并列第一作者), wen-ning wu, dan-fang yu, qiu-ju xiong, jian-ren song, qing shu, hui fu, fang wang and jian-guo chen. existence and distinction of acid-evoked currents in rat astrocytes. glia. 2010 sep;58(12):1415-24. (sci, if=4.932)

⑤. zhuangli hu, juan chen, qin wei, and yong xia. bidirectional actions of hydrogen peroxide on endothelial nitric oxide synthase phosphorylation and function: co-commitment and interplay of akt and ampk. j. biol. chem. 2008 sep 12; 283(37): 25256-25263. (sci, if=5.328)

⑥. bo jiang, wei wang, fang wang, zhuang-li hu, jun-li xiao, si yang, jing zhang, xiao-zhong peng, jin-hui wang, jian-guo chen. the stability of nr2b in the nucleus accumbens controls behavioral and synaptic adaptations to chronic stress. biol psychiatry. 2013 jul 15; 74(2):145-155.

⑦. jun-qi zhang, peng-fei wu, li-hong long, yu chen, zhuang-li hu, lan ni, fang wang, jian-guo chen. resveratrol promotes cellular glucose utilization in primary cultured cortical neurons via calcium-dependent signaling pathway. j nutr biochem. 2012 jul 20. [epub ahead of print]

⑧. yu chen, jun zhou, na xie, chao huang, jun-qi zhang, zhuang-li hu, lan ni, you jin, fang wang, jian-guo chen and li-hong long. lowering glucose level elevates [ca2+]i in hypothalamic arcuate nucleus npy neurons through p/q-type ca2+ channel activation and gsk3β inhibition. acta pharmacol sin. 2012 may;33(5):594-605.

⑨. yan-kun li, fang wang, wei wang, yi luo, peng-fei wu, jun-li xiao, zhuang-li hu, you jin, gang hu and jian-guo chen. aquaporin-4 deficiency impairs synaptic plasticity and associative fear memory in the lateral amygdala: involvement of downregulation of glutamate transporter-1 expression. neuropsychopharmacology. 2012 jul; 37(8):1867-78.

⑩. bo jiang, zhe xiong, jun yang, wei wang, yue wang, zhuang-li hu, fang wang, jian-guo chen. antidepressant-like effects of ginsenoside rg1 are due to activation of the bdnf signalling pathway and neurogenesis in the hippocampus. br j pharmacol. 2012 jul;166(6):1872-87.

?. xiong z, jiang b, wu pf, tian j, shi ll, gu j, hu zl, fu h, wang f, chen jg. antidepressant effects of a plant-derived flavonoid baicalein involving extracellular signal-regulated kinases cascade. biol pharm bull. 2011; 34(2):253-9.

?. yang j, hu zl, jiang b, ni l, jin y, chen jg, wang f. effect of chloramine-t on long-term potentiation at synapses between perforant path and dentate gyrus in hippocampus of rats in vivo. neurotoxicology. 2011 mar; 32(2):199-205.

?. wang w, zheng ll, wang f, hu zl, wu wn, gu j, chen jg. tanshinone iia attenuates neuronal damage and the impairment of long-term potentiation induced by hydrogen peroxide. j ethnopharmacol. 2011 mar 8; 134(1):147-55.

?. wang w, wang f, yang yj, hu zl, long lh, fu h, xie n, chen jg. the flavonoid baicalein promotes nmda receptor-dependent long-term potentiation and enhances memory. br j pharmacol. 2011 mar; 162(6):1364-79.

?. wang t, yang yj, wu pf, wang w, hu zl, long lh, xie n, fu h, wang f, chen jg. tetrahydroxystilbene glucoside, a plant-derived cognitive enhancer, promotes hippocampal synaptic plasticity. eur j pharmacol. 2011 jan 10;650(1):206-14.

?. yang yj, wu pf, long lh, yu df, wu wn, hu zl, fu h, xie n, jin y, ni l, wang jz, wang f, chen jg. reversal of aging-associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and nmda receptor function. aging cell. 2010 oct; 9(5):709-21.

?. yang mj, wang f, wang jh, wu wn, hu zl, cheng j, yu df, long lh, fu h, xie n, chen jg. pi3-k integrates the effects of insulin and leptin on large-conductance ca2+-activated k+ channels in neuropeptide y neurons of the hypothalamic arcuate nucleus. am j physiol endocrinol metab. 2010 feb; 298(2):e193-201.

?. li-hong long, jue liu, rui-li liu, fang wang, zhuang-li hu, na xie, hui fu, jian-guo chen. differential effects of methionine and cysteine oxidation on [ca2+]i in cultured hippocampal neurons. cell mol neurobiol. 2009, 29(1):7-15.

?. long lh, liu rl, wang f, liu j, hu zl, xie n, jin y, fu h, chen jg. age-related alterations at hippocampal synapses and deficits in spatial memory in rats. clin exp pharmacol physiol. 2009 jul; 36(7):675-81.

?. liu j, wang w, wang f, cai f, hu zl, yang yj, chen j, chen jg. phosphatidylinositol-linked novel d(1) dopamine receptor facilitates long-term depression in rat hippocampal ca1 synapses. neuropharmacology. 2009 aug; 57(2):164-71.

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