学习及科研经历

杨振华，华中科技大学同济医学院基础医学院教授、博士生导师。2012年于武汉大学生命科学学院获得微生学专业博士学位，2012-2018年在美国阿拉巴马州-伯明翰大学从事博士后/助理研究员工作，2018年11月作为课题组长入职华中科技大学同济基础医学院。

研究领域：

本实验室利用体内和体外各种研究方案，对造血干细胞分化调控及血液肿瘤发生发展的分子机理进行深入研究，并致力于在此基础上的抗肿瘤转化医学研究。

联系方式：

地址：同济基础医学院2号楼1221室; 邮箱：zhenhua@hust.edu.cn

发表主要论文

1. Zhenhua Yang*· Hao Jiang*. A chromatin perspective on metabolic and genotoxic impacts on hematopoietic stem and progenitor cells. Cellular and Molecular Life Sciences. 2020 https://doi.org/10.1007/s00018-020-03522-x

2. Zhenhua Yang*, Kushani Shah, Alireza Khodadadi-Jamayran, Hao Jiang*. Control of Hematopoietic Stem and Progenitor Cell Function Through Epigenetic Regulation of Energy Metabolism and Genome Integrity. Stem Cell Reports. 2019; 13, 61-75.

3. Zhenhua Yang^#, Kushani Shah^#, Theodore Busby, Robert Whitaker, Keith Giles, Alireza Khodadadi-Jamayran, Jing Hu, William Placzek, and Hao Jiang. Hijacking a key chromatin modulator creates targetable epigenetic vulnerability for Myc-driven cancer. Journal of Clinical Investigation. 2018;128, 3605-3618.

4. Zhenhua Yang, Kushani Shaha, Alireza Khodadadi-Jamayran, and Hao Jiang. Dpy30 Is Critical for Maintaining the Identity and Function of Adult Hematopoietic Stem Cells. The Journal of Experimental Medicine. 2016, doi/ 10.1084/jem.20160185.

5. Jing Hu, Alireza Khodadadi-Jamayran, Miaowei Mao, Kushani Shah, Zhenhua Yang, Talat Nasim, Zefeng Wang, and Hao Jiang†. AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors. Nature Communications. 2016 Nov 8;7:13347. doi: 10.1038/ ncomms13347.

6. Zhenhua Yang, Jonathan Augustin, Jing Hu, and Hao Jiang. Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS One. 2015, 10(12): 0145336.

7. Zhenhua Yang^#, Jonathan Augustin^#, Chenbei Chang, Jing Hu, Kushani Shah, Chia-Wei Chang, Tim Townes, and Hao Jiang. The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells. Blood. 2014, 124(13): 2025-33.

8. Zhenhua Yang, Wu R, Li RW, Li L, Xiong Z, Zhao H, Guo D, Pan Z. Chimeric classical swine fever (CSF)-Japanese encephalitis (JE) viral replicon as a non-transmissible vaccine candidate against CSF and JE infections. Virus Res. 2012 Apr; 165(1):61-70.

9. Zhenhua Yang, Ling Li, Zishu Pan. Development of multiple ELISAs for the detection of antibodies against classical swine fever virus in pig sera. Virologica Sinica. 2012, 27(1):48-56.

10. Jing Qu, Zhenhua Yang,  Qi Zhang, Weiyong Liu, Youxing Li, Qiong Ding, Fang Liu, Yingle Liu, Zishu Pan, Biao He, Ying Zhu, Jianguo Wu, Human immunodeficiency virus-1 Rev protein activates hepatitis C virus gene expression by directly targeting the HCV 5′-untranslated region. FEBS. 2011, 585: 4002-4009.

11. Zhenhua Yang, Pan Tao, Siyu Zhou, Shuwen Wu, Zishu Pan. Expression of neuraminidase of H5N1 subtype avian influenza virus and production of polyclonal antibody. Journal of WuHan University. 2007, 53:481-484.

# Equal contribution; *Corresponding author