赵俊

工作单位： 华中科技大学同济医学院基础医学院解剖系职位： 教授

电子邮箱: junzhao1981@hust.edu.cn

教育背景

1999-2004 中国科学技术大学化学系学士学位

2005-2006 美国印第安纳大学-普渡大学印第安纳波利斯分校 (Indiana University Purdue University Indianapolis) 生物医学工程系硕士学位

2006-2009 美国普渡大学（Purdue University）生物医学工程系哲学博士学位（导师：Professor Dong Xie）

工作经历

2009-2015 博士后，美国得克萨斯大学安德森癌症中心（导师：李春教授）

2015-2019 讲师， 美国得克萨斯大学安德森癌症中心癌症系统影像系

2019-至今 教授，华中科技大学同济医学院基础医学院解剖系

研究领域

纳米医学、介入治疗、免疫治疗、核医学影像。主要研究方向：新型纳米药剂的开发与临床转化、肿瘤靶向药物递送、肿瘤微环境调节与疗效增敏。

主要学术成果

本人的研究对象，是以胰腺癌为代表的具有高度耐药性的实体肿瘤。针对胰腺癌纤 维化程度高、药物递送困难的特点，开发了一种新型高分子纳米载体，在多个动物模型中 成功调节了肿瘤微环境，提高了药物递送效率，并显著增强了放、化疗与免疫治疗的疗效。成果已发表于 Journal of Controlled Release、Biomaterials 及 ACS Nano 等。该纳米制剂已在中美两国申请专利。此外，本人在国际上首先阐明，不可逆电穿孔介入疗法（IRE）可 降低胰腺肿瘤微环境的免疫抑制性。利用 IRE 显著提高了免疫检查点抑制剂对胰腺癌的疗效。成果将于近期发表于 Nature Communications。本人对肿瘤光热治疗及核医学影像方向也有涉及， 成果发表于 Biomaterials，Applied Materials Today 、Nanoscale 等 。近五年内以第一作者或共同第一作者身份发表学术论文 14 篇，涵盖药学、材料学和影像学等领域， 共计影响因子 98.3。已主持或参与学术基金 4 项。长期担任 Advanced Functional Materials,

Acta Biomaterialia 等国际期刊审稿人。科研基金

1. 纳米药物缓释调控肿瘤相关中性粒细胞以增强胰腺癌对不可逆电穿孔联合 PD1 单抗治疗响应的研究，国家自然科学基金面上项目 82073400，2021.01-2024.12，55 万元，主持

2. Improve Radiation Efficacy in Pancreatic Tumor using Nanoparticle-bound Radiosensitizer，安德森癌症中心，4/1/2016-3/31/2017, $30,000，项目负责人

3. Determination of the efficacy of TIG1-targeted therapy using nanoparticle-delivered siRNA in inflammatory breast cancer, Morgan Welch 炎性乳腺癌研究计划, 4/1/2016- 3/31/2017, $40,000，项目共同负责人

4. Targeted Delivery of Cyclopamine by Biodegradable Cross-Linked Polymeric Micelles for Radio-Chemotherapy of Pancreatic Cancer ， Skip Viragh 基金会， 2012-2018 ，

$1,400,000，合作研究人

5. Simultaneous Ablation of Tumor Cells and Tumor Stromal Cells to Enhance Antitumor against Pancreatic Ductal Adenocarcinoma，Gillson Longenbaugh 基金会，2016-2018，

$80,000，合作研究人

专利

Chun Li, Jun Zhao, Jason Fleming. Polymeric Drug Delivery Systems for Treatment of Disease, United States, 62/265,167, Pending

代表性 SCI 论文

1. Lincha, V. R. †; Zhao, J. †; Wen, X.; Xiong, C.; D, S. L. Chow; and Li, C., A polymeric micellar drug delivery system developed through a Design of Experiment approach improves pancreatic tumor accumulation of calcipotriol and paclitaxel. International

Journal Pharmaceutics, 2021: p. 120523（影响因子 4.845）

2. Bao, G.; Tang, M.; Zhao, J.*; and Zhu, X.*, Nanobody: a promising toolkit for molecular imaging and disease therapy. EJNMMI Res, 2021. 11(1): p. 6. DOI: 10.1186/s13550-021-

00750-5（影响因子 2.640）

3. Wu, Z. L. †; Zhao, J. †; and Xu, R., Recent advances in oral nano-antibiotics for bacterial infection therapy. Interntional Journal of Nanomedicine, 2020. 15: p. 9587-9610（影响因子 5.115）

4. Xiong, C.; Wen, Y.; Zhao, J.; Yin, D.; Xu, L.; Chelariu-Raicu, A.; Yao, C.; Leng, X.; Liu, J.; Chaudhari, RR.; Zhang, S.; Sood, AK.; Li, C. Targeting Forward and Reverse EphB4/EFNB2 Signaling by a Peptide with Dual Functions. Scientific Reports, 2020. 10(1): p. 520（影响因子 3.998）

5. Lincha, V. R.; Hsiao, C.-H.; Zhao, J.; Li, C.; Chow, D. S.-L. Sensitive and rapid UHPLC– MS/MS assay for simultaneousquantifications of calcipotriol and paclitaxel in rat whole blood andplasma samples. Journal of Pharmaceutical and Biomedical Analysis, 2021, 192: 113685（影响因子 3.209）

6. Cao, Q. †; Wang, W. †; Zhou, M. †; Huang, Q.; Wen, X.; Zhao, J.; Shi, S.; Geng, K.; Li, F.; Hatakeyama, H.; Xu, C.; Piwnica-Worms, D.; Peng, W.; Zhou, D.; Sood, A. K.; and Li, C., Induction of antitumor immunity in mice by the combination of nanoparticle-based photothermolysis and anti-PD-1 checkpoint inhibition. Nanomedicine: Nanotechnology, Biology and Medicine, 2020. 25: p. 102169（影响因子 5.182）

7. Zhao, J.†; Wen, X.†; Li, T.; Shi, S.; Xiong, C.; Wang, Y. A.; and Li, C., Concurrent Injection of Unlabeled Antibodies Allows Positron Emission Tomography Imaging of Programmed Cell Death Ligand 1 Expression in an Orthotopic Pancreatic Tumor Model. ACS Omega, 2020, 5(15): p. 8474-8482（共同一作，影响因子 2.87）

8. He, J. †; Qiao, Y. †; Zhang H. †; Zhao, J. †; Li, W.; Xie, T.; Zhong, D.; Wei, Q.; Hua, S.; Yu, Y.; Yao, K.; Santos, H.; Zhou M. Gold–silver nanoshells promote wound healing from drug-resistant bacteria infection and enable monitoring via surface-enhanced Raman scattering imaging. Biomaterials 2020, 234, 119763（共同一作，影响因子 10.274）

9. Zhong, D. †; Zhao, J. †; Li, Y; Qiao, Y.; Wei, Q.; He, J.; Xie, T.; Li, W., Zhou, M. Laser- triggered aggregated cubic α-Fe2O3@Au nanocomposites for magnetic resonance imaging and photothermal/enhanced radiation synergistic therapy. Biomaterials 2019, 210, 119369

（共同一作，影响因子 10.274）

10. Zhao, J.†; Wen, X. F.†; Tian, L.; Li, T.; Xu, C.; Wen, X. X.; Melancon, M. P., Gupta, S.; Shen, B.; Peng, W.; Li, C. Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer. Nature Communications 2019, 10:899（影响因子 11.880）

11. Zhao, J.; Xiao, Z.; Li, T.; Chen, H.; Yuan, Y.; Wang, A. Y.; Hsiao, C. -H.; Chow, D. S.- L.; Overwijk, W.; Li, C. Stromal modulation reverses primary resistance to immune checkpoint blockade in pancreatic cancer. ACS Nano 2018, 12, 9881-9893.（影响因子13.709）

12. Zhou, B.†; Zhao, J.†; Qiao, Y.; Wei, Q.; He, J.; Li, W.; Zhong, D.; Ma, F.; Li, Y.; Zhou,

M. Simultaneous multimodal imaging and photothermal therapy via renal-clearable manganese-doped copper sulfide nanodots. Applied Materials Today 2018, 13, 285-297.

（共同一作，影响因子 8.013）

13. Zhao, J.; Wang, H.; Hsiao, C.-H.; Chow, D. S.-L.; Koay, E. J.; Kang, Y.; Wen, X.; Huang, Q.; Ma, Y.; Bankson, J. A.; et al. Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy. Biomaterials 2018, 159, 215-228. （影响因子 10.273）

14. Zhao, J.; Koay, E. J.; Li, T.; Wen, X.; Li, C., A hindsight reflection on the clinical studies of poly (l‐glutamic acid)‐paclitaxel. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2018, 10 (3), e1497.（影响因子 6.35）

15. Wang, W.†; Zhao, J.†; Wen, X.; Lin, C. C.-J.; Li, J.; Huang, Q.; Yu, Y.; Lin, S.-Y.; Li, C., MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer. Contrast Media & Molecular Imaging 2017, 2017. （共同一作，影响因子 2.934）

16. Zhao, J.; Zhou, M.; Li, C., Synthetic nanoparticles for delivery of radioisotopes and radiosensitizers in cancer therapy. Cancer Nanotechnology 2016, 7 (9). (影响因子 4.22）

17. Zhou, M.; Zhao, J.; Tian, M.; Song, S.; Zhang, R.; Gupta, S.; Tan, D.; Shen, H.; Ferrari, M.; Li, C., Radio-photothermal therapy mediated by a single compartment nanoplatform depletes tumor initiating cells and reduces lung metastasis in the orthotopic 4T1 breast tumor model. Nanoscale 2015, 7 (46), 19438-19447.（影响因子 7.233）

18. Zhou, M.; Song, S.; Zhao, J.; Tian, M.; Li, C., Theranostic CuS nanoparticles targeting folate receptors for PET image-guided photothermal therapy. Journal of Materials Chemistry B 2015, 3 (46), 8939-8948.（影响因子 4.543）

19. Zhao, J.; Wu, C.; Abbruzzese, J.; Hwang, R. F.; Li, C., Cyclopamine-loaded core-cross- linked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells. Molecular Pharmaceutics 2015, 12 (6), 2093-2100. （影响因子 4.556）

20. Zhao, J.; Qiao, Y.; Zhou, M.; Wallace, M.; Gupta, S.; Li, C.; Melancon, M. P., Antitumor Efficacy of Irreversible Electroporation and Doxorubicin-Loaded Polymeric Micelles. ACS Macro Letters 2015, 4 (10), 1081-1084.（影响因子 6.131）

21. Zhao, J.; Lee, P.; J Wallace, M.; P Melancon, M., Gold nanoparticles in cancer therapy: efficacy, Biodistribution, and Toxicity. Current Pharmaceutical Design 2015, 21 (29), 4240-4251.（影响因子 2.757）

22. You, J.†; Zhao, J.†; Wen, X.; Wu, C.; Huang, Q.; Guan, F.; Wu, R.; Liang, D.; Li, C., Chemoradiation therapy using cyclopamine-loaded liquid–lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles. Journal of Controlled Release 2015, 202, 40-48. （共同一作，影响因子 7.877）

23. Zhao, J.; Wallace, M.; Melancon, M. P., Cancer theranostics with gold nanoshells.

Nanomedicine 2014, 9 (13), 2041-2057.（影响因子 5.005）

24. Zhao, J.; Vykoukal, J.; Abdelsalam, M.; Recio-Boiles, A.; Huang, Q.; Qiao, Y.; Singhana, B.; Wallace, M.; Avritscher, R.; Melancon, M. P., Stem cell-mediated delivery of SPIO- loaded gold nanoparticles for the theranosis of liver injury and hepatocellular carcinoma. Nanotechnology 2014, 25 (40), 405101.（影响因子 3.404）

25. Zhao, J.†; Song, S.†; Zhong, M.; Li, C., Dual-Modal Tumor Imaging via Long-Circulating

Biodegradable Core-Cross-Linked Polymeric Micelles. ACS Macro Letters 2011, 1 (1), 150-153. （影响因子 6.131)

国际会议报告邀请报告

1. Zhao J., Wu C., Li J., Hwang R.,Li C. “Cyclopamine-loaded Core-crosslinked Polymeric Micelles Enhanced Radiation Response in Pancreatic Cancer”. 10th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, Valencia, Spain, 5/2014