马婧薇，华中科技大学同济医学院免疫学系教授，博士研究生导师。2012年在华中科技大学获得医学免疫学博士学位。2012年至2015在中国医学科学院基础医学研究所免疫学系黄波教授课题组从事博士后研究。2016年入职华中科技大学同济医学院免疫学系。2016年获得中国免疫学会“第六届青年学者奖”，2022年入选湖北省青年拔尖人才计划，2024年入选“教育部长江学者奖励计划”青年学者，现为中国免疫学会女科学家工作委员会和中国抗癌协会肿瘤生物治疗专业委员会委员。

研究方向主要为肿瘤免疫、细胞代谢调控和免疫衰老。主持国家自然基金委课题青年基金项目、面上项目、重大研究计划、重大项目子课题等，近年来以第一/通讯作者在Nature Immunology、Nat Cell Biol、Nat Commun、Cell Res、Cell Mol Immunol、Immunity & Inflammation、Signal Transduct Target Ther等杂志发表SCI论文。作为团队主要成员研发“载药囊泡治疗肿瘤技术”，获北京市科学技术奖自然科学奖一等奖，该项目已完成临床转化进入应用阶段。

代表性研究成果：

1. Ma J#, Tang L#, Tan Y#, Xiao J, Wei K, Zhang X, Ma Y, Tong S, Chen J, Zhou N, Yang L, Lei Z, Li Y, Lv J, Liu J, Zhang H, Tang K, Zhang Y, Huang B*. Lithium carbonate revitalizes tumor-reactive CD8⁺ T cells by shunting lactic acid into mitochondria. Nat Immunol. 2024 Mar; 25(3):552-561.

2. Ma J, Tong S, Xiao J, Huang B*. Mannose: A game-changer for T cell immunotherapy. Cell Metab. 2025 Feb 4;37(2):313-315.

3. Wei K#, Tang L#, Zhang X#, Liu S, Tong S, Bian Y, Ma Y, Zhu T, Xiao J, Lin Q, Zhang R, Lv J, Zhang H, Tang K, Wu S, Ma J* & Huang B*. Lithium carbonate induces myofibroblast necroptosis to reverse pulmonary fibrosis. Immunity & Inflammation. 2025.1, 3.

4. Ma K#, Xu Y#, Cheng H#, Tang K#, Ma J#, Huang B*. T cell-based cancer immunotherapy: opportunities and challenges. Sci Bull (Beijing). 2025 Mar 31: S2095-9273(25)00337-8.

5. Tong S, Xiao J, Zhang X, Ma J*. Lithium: Emerging frontiers in metallopharmaceutical therapeutics. Molecular Immunology. 2025, 185: 39-52.

6. Ma J*, Tang L, Xiao J, Tang K, Zhang H, Huang B*. Burning lactic acid: a road to revitalizing antitumor immunity. Front Med. 2025 Mar 22.

7. Chen S#, Wang K#, Fan Z, Zhou T, Li R, Zhang B, Chen J, Chi J, Wei K, Liu J, Liu Z, Ma J*, Dong N* & Liu J*. Modulation of anti-cardiac fibrosis immune responses by changing M2 macrophages into M1 macrophages. Molecular Medicine. 2024, 30(1): 88.

8. Wei K#, Zhang H#, Yang S, Cui Y, Zhang B, Liu J,Tang L, Tan Y, Liu S, Yuan W, Luo X, Chen C, Li F, Liu J, Chen J, Xu P, Lv J, Tang K, Zhang Y, Ma J*, Huang B*. Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1. Signal Transduct Target Ther. 2023 Jan 20;8(1):22.

9. Tang K#, Ma J#, Huang B*. Macrophages' M1 or M2 by tumor microparticles: lysosome makes decision. Cell Mol Immunol. 2022 Oct;19(10):1196-1197.

10. Ma J#, Tang K#, Zhang H#, Wei K, Huang B*. Characterization and Functional Analysis of Tumor-Derived Microparticles. Curr Protoc. 2021 Jun;1(6):e144.

11. Ma J, Zhang H, Tang K, Huang B*. Tumor-derived microparticles in tumor immunology and immunotherapy. Eur J Immunol. 2020 Sep 25.

12. Ma J#, Wei K#, Liu J#, Tang K, Zhang H, Zhu L, Chen J, Li F, Xu P, Chen J, Liu J, Fang H, Tang L, Wang D, Zeng L, Sun W, Xie J, Liu Y, Huang B*. Glycogen metabolism regulates macrophage-mediated acute inflammatory responses. Nat Commun. 2020 Apr 14;11(1):1769.

13. Zhang H#, Tang K#, Ma J#, Zhou L, Liu J, Zeng L, Zhu L, Xu P, Chen J, Wei K, Liang X, Lv J, Xie J, Liu Y, Wan Y, Huang B*. Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T cell memory development. Nat Cell Biol. 2020 Jan;22(1):18-25.

14. Ma J#, Wei K#, Zhang H, Tang K, Li F, Zhang T, Liu J, Xu P, Yu Y, Sun W, Zhu L, Chen J, Zhou L, Liang X, Lv J, Fiskesund R, Liu Y, Huang B*. Mechanisms by which dendritic cells present tumor microparticle antigens to CD8+ T cells. Cancer Immunol Res. 2018 Jul 17.

15. Ma J#, Zhang Y#, Tang K, Yin X, Zhang H, Li Y, Zhang S, Hu Z, Wang N, Yang X, Huang B*. Delivery of chemotherapeutic drug by tumor cell-derived microparticles reverses drug resistance of tumor-repopulating cells. Cell Res. 2016 Jun; 26(6):713-27.

16. Jin X#, Ma J#, Liang X#, Tang K, Liu Y, Yin X, Zhang Y, Zhang H, Xu P, Chen D, Zhang T, Lu J, Hu Z, Qin X, Zeng X, Li L, Huang B*. Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder cancer through a lysosomal pathway. Biomaterials. 113:93-104. 2017.

17. Ma J#, Cai W#, Zhang Y, Huang C, Zhang H, Liu J, Tang K, Shen G*, Huang B*. Innate immune cell-derived microparticles facilitate hepatocarcinoma metastasis by transferring integrin α(M)β₂ to tumor cells. J Immunol. 191:3453-61. 2013.

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