王维民

教授，博士生导师

海外高层次人才（青年千人）

湖北省百人计划

湖北省杰出青年项目

华中科技大学基础医学院免疫系

研究方向：细胞代谢和肿瘤免疫治疗

个人简介：2006年毕业于兰州大学并取得生物学学士学位，2011年毕业于北京协和医学院基础学院生物化学与分子生物学专业并取得博士学位，2011年至2019年期间先后在美国密歇根大学医学院妇产科和外科进行博士后研究。2019年入职华中科技大学基础医学院免疫学系任教授、博士生导师，现担任基础医学院副院长、免疫学系主任。入选国家“海外高层次人才（青年项目）”、湖北省“百人计划”，兼任湖北省医学生物免疫学基础免疫专委会主委、中国免疫学会细胞治疗专委会委员、中国细胞生物学会细胞死亡专委会委员。承担科技部国家重点研发计划、国家自然科学基金和湖北省杰出青年基金等项目6项。在探索效应性T细胞对肿瘤细胞代谢和死亡调控领域取得了一系列创新性研究成果，近年来主要代表性成果发表在Nature、Cell、Cancer Cell、Cell Metabolism和Nature Communications等国际主流学术期刊。目前主要从事细胞死亡、脂质代谢及肿瘤免疫调控相关研究。

联系方式：

武汉市航空路13号基础医学院2号楼1022

email:  weiminw@hust.edu.cn

代表性学术论文：

1. Lai Y, Gao Y, Lin J, Liu F, Yang L, Zhou J, Xue Y, Li Y, Chang Z, Li J, Chao T, Chen J, Cheng X, Gao X, Li X, Lu F, Chu Q, Wang W. Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5. Cell Metabolism. 2024 Feb 8:S1550-4131(24)00012-3.

2. Xue Y, Lu F, Chang Z, Li J, Gao Y, Zhou J, Luo Y, Lai Y, Cao S, Li X, Zhou Y, Li Y, Tan Z, Cheng X, Li X, Chen J, Wang W. Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade. Nature Communications. 2023 Aug 8;14(1): 4758.

3. Liao P*, Wang W*, Wang W, Kryczek I, Li X, Bian Y, Sell A, Wei S, Grove S, Johnson JK, Kennedy PD, Gijón M, Shah YM, Zou W. CD8⁺ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell. 2022 Feb; S1535-6108(22)00036-8 (co-first)

4. Wang W*, Zou W*. Amino acid and their transporters in T cell immunity and cancer therapy. Molecular Cell. 2020 Nov; 80(3):384-395 (co-corresponding).

5. Wang W, Green M, Choi JE, Gijón M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, Xia H, Zhou J, Li G, Li J, Li W, Wei S, Vatan L, Zhang H, Szeliga W, Gu W, Liu R, Lawrence TS, Lamb C, Tanno Y, Cieslik M, Stone E, Georgiou G, Chan TA, Chinnaiyan A, Zou W. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019 May;569(7755):270-274.

6. Wang W, Kryczek I, Dostál L, Lin H, Tan L, Zhao L, Lu F, Wei S, Maj T, Peng D, He G, Vatan L, Szeliga W, Kuick R, Kotarski J, Tarkowski R, Dou Y, Rattan R, Munkarah A, Liu JR, Zou W. Effector T cells abrogate stroma-mediated chemoresistance in ovarian cancer. Cell. 2016 May 19; 165(5): 1092-105.

7. Wang W, Zou W, Liu R. Tumor-infiltrating T cells in epithelial ovarian cancer: predictors of prognosis and biological basis of immunotherapy. Gynecol Oncol. 2018 Oct;151(1):1-3.

8. Wang W, Liu JR, Zou W. Immunotherapy in Ovarian Cancer. Surg Oncol Clin N Am. 2019 Jul; 28(3):447-464.

9. Wang W, Green M, Liu R, Lawrence T, Zou W. CD8+ T cells in Immunotherapy, Radiotherapy and Chemotherapy. Oncoimmunology, 2018. doi.org/10.1007/978-3-319-62431-0_3.

10. Wang W, Zhou J, Zhang Y, Liu S, Liu Y, Zheng D. HTLV-1 Tax-deregulated both autophagy pathway and c-FLIP expression contribute to the resistance against death receptor-mediated apoptosis. J Virol. 2014 Mar; 88(5):2786-98.

11. Lang X, Green MD, Wang W, Yu J, Choi JE, Jiang L, Liao P, Zhou J, Zhang Q, Dow A, Saripalli AL, Kryczek I, Wei S, Szeliga W, Vatan L, Stone EM, Georgiou G, Cieslik M, Wahl DR, Morgan MA, Chinnaiyan AM, Lawrence TS, Zou W. Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11. Cancer Discov. 2019 Dec; 9(12):1673-1685.

12. Maj T, Wang W, Wang W, Wei S, Zhao L, Linda Vatan L, Szeliga W, Liu R, Kryczek I, Zou W. Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1 blockade in the tumor microenvironment. Nat Immunol, 2017 Dec;18(12):1332-1341.

13. Tan L, Wang W, He G, Kuick RD, Gossner G, Kueck AS, Wahl H, Opipari AW, Liu JR. Resveratrol inhibits ovarian tumor growth in an in vivo mouse model. Cancer. 2016 Mar 1; 122(5): 722-9.

14. Peng D, Kryczek I, Nagarsheth N, Zhao L, Wei S, Wang W, Sun Y, Zhao E, Vatan L, Szeliga W, Kotarski J, Tarkowski R, Dou Y, Cho K, Hensley-Alford S, Munkarah A, Liu R, Zou W. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature. 2015 Nov 12; 527(7577): 249-53