杨红枚，华中科技大学同济医学院基础医学院人才引进特聘教授、博士生导师。毕业于武汉大学病毒学专业；留学美国十年，先后在哈佛医学院和美国生物医药公司从事病毒免疫、蛋白质代谢和肿瘤生物学的研究及肿瘤治疗药物的研发。现任湖北省微生物学学会常务理事，微生物及免疫学会理事，国家自然科学基金委和教育部通讯评审专家等社会职务。共计发表科研论文30余篇，其中已被sci收录近二十篇。

研究方向：

1.       感染与肿瘤

2.       丙型肝炎病毒致病机制及抗病毒药物研发

3.       蛋白质代谢与肿瘤恶病质

主要论文：

1.      chen x, han w, ruan a, zhao y, xu z, lu x, yang h*, zhang x*. mir-141 is a key regulator of renal cell carcinoma proliferation and metastasis by controlling epha2 expression. clinical cancer research. 2014  ( if：7.8，共同通讯作者)

2.      yang  h, chen x, wang x, li y, chen s, qian x, wang r, chen l, han w, ruan a, du q, olumi af, zhang x*. inhibition of pp2a activity confers a trail-sensitive phenotype during malignant transformation. mol cancer res, feb;12(2):217-27, 2014 ( if：4.6，第一作者)

3.      wang x. chen x, wang r, xiao p, xu z, chen l, han w, ruan a, yang h*, zhang x*. microrna-200c modulates the epithelial-to-mesenchymal transition in human renal cell carcinoma metastasis. oncol rep,30(2): p. 643-50. 2013 ( if：2.2，共同通讯作者)

4.      hongmei yang, charles h. lin, gang ma, michael baffi and marc g. wathelet  transcriptional activity of interferon regulatory factor (irf)-3 depends on multiple protein-protein interactions. febs j. (eur. j. biochem.); 269(24): 6142-51, 2002 dec.

5.      hongmei yang, charles h. lin, gang ma, michael baffi and marc g. wathelet  interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/cbp coactivators. j biol chem.; 278(18): 15495-504, 2003 may 2.

6.      hongmei yang, gang ma, michael baffi and marc g. wathelet. mechanism for transcriptional synergy between interferon regulatory factor (irf)-3 and irf-7 in activation of the interferon-beta gene promoter. febs j. (eur. j. biochem.); 271(18): 3693-703, 2004 sep.

7.      hongmei yang, wei wei , michael menconi, and per-olof hasselgren.  dexamethasone-induced protein degradation in cultured myotubes is p300/hat-dependent. am i physiol regul integr comp physiol.; 292(1):r337-4, 2007 jan.

8.      hongmei yang, joshua mammen, micahel menconi, per-olof hasselgren. expression and activity of c/ebpbeta and delta are upregulated by dexamethasone in skeletal muscle. j cell physiol.; 204(1): 219-26, 2005 july.

9.      hongmei yang, mike menconin, per-olof hasselgren. dexamethasone upregulates the expression of the nuclear cofactor p300 and its interaction with c/ebp beta in cultured myotubes. j cell biochem.; 94(5): 1058-67, 2005 apr 1.

10.  xiaoping zhang, liang zhang, hongmei yang, xu huang, hasan otu, towia a. libermann,, william c. dewolf, roya khosravi-far, aria f. olumi. c-fos as a proapoptotic agent in trail-induced apoptosis in prostate cancer cells. cancer res; 67(19): 9425-34,2007 oct 1.

11.  wei wei , hongmei yang , peirang cao , michael menconi, and per-olof hasselgren.  treatment of cultured myotubes with the proteasome inhibitor β-lactone increase the expression of the transcription factor c/ebp β. am j physiol cell physiol.; 292(1):c216-26, 2007 jan.

12.  wei wei , hongmei yang,  peirang cao , michael menconi, petkova v, hasselgren po. degradation of c/ebp β in cultured myotubes is calpain-dependent. j cell physiol.; 208(2): 386-98,2006 aug.

13.  hasselgren po, menconi mj, fareed mu, yang h, wei w, evenson a. novel aspects on the regulation of muscle wasting in sepsis. int j biochem cell biol. 2005 oct;37(10):2156-68. epub 2005 mar 13

14.  wei wei, fareed mu, evenson a, menconi mj, hongmei yang , petkova v, hasselgren po. sepsis stimulates calpain activity in skeletal muscle by decreasing calpastatin activity but does not activate caspase-3. am j physiol regul integr comp physiol. 2005 mar; 288(3):r580-90.

15.  xiaoping zhang, tai-guang jin, hongmei yang, william c. dewolf, roya khosravi-far and aria f. olumi. persistent c-flip(l) expression is necessary and sufficient to maintain resistance to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in prostate cancer. cancer res. 2004 oct 1; 64(19): 7086-91.

16.  menconi mj, wei w, hongmei yang, wray cj, hasselgren po. treatment of cultured myotubes with the calcium ionophore a23187 increases proteasome activity via a camk ii-caspase-calpain-dependent mechanism. surgery. 136(2): 135-42, 2004 aug.

主要著作：

杨红枚参编，《病毒转基因技术原理》。科学出版社，2014年。

科研项目：

1.       microrna-141调控hcv复制的机制研究，病毒学国家重点实验室开放课题，2014-2016年；

2.       恶病质肌肉萎缩中myostatin表达调控的机制研究，国家自然科学基金面上项目，2012-2015年；

3.       病毒激活因子（vaf）调控丙型肝炎病毒诱导的干扰素表达机制的研究，国家自然科学基金面上项目，2011-2013年。

4.       恶病质肌肉萎缩中myostatin表达调控的机制研究，湖北省科技厅面上项目，2011-2012年；

5.       丙型肝炎病毒感染的肝细胞对trail敏感的机制研究，湖北省卫生厅科研一般项目，2011-2012年。

6.       hcv感染的肝细胞对trail敏感的机制研究，华中科技大学自主创新研究基金资助项目，2010-2012年。