史岸冰

华中学者领军岗特聘教授

生物化学和分子生物学系

电话：027-83692608

电子邮箱：ashi@hust.edu.cn

关键词：Endosome cell biology, small GTPase, membrane skeleton, and modeling human diseases in Caenorhabditis elegans 

• 现任华中科技大学同济基础医学院院长，华中科技大学细胞架构研究中心主任，生物化学和分子生物学系主任。于南开大学获理学学士学 位，美国罗格斯大学获硕士和博士学位，美国斯坦福大学进行博士后训练，2013年回到华中科技大学开展独立研究工作。

• 主讲《医学细胞及分子生物学》、《生物化学及分子生物学》、《遗传学》等本科生及研究生课程。担任《医学细胞与分子生物学》八年制临床整合课程负责人、研究生《代谢与疾病基础研究实验技术》课程负责人，现任医学研究生国家级规划教材《医学分子生物学》主编，医学研究生国家级规划教材《细胞与分子生物学》主编，五年制本科临床医学国家级规划教材《医学细胞生物学》副主编。

• 主要从事内膜动态及功能相关的基础研究，运用遗传操作、超高分辨成像、光遗传操控、体外重构等多学科方法，探讨内吞体生理病理动态（Ras家族蛋白活性调控；膜骨架动态；膜运输调控网络组成及功能模式）、内吞体调控组织衰老、内吞体调控病原微生物-宿主互作等科学问题，相关成果以通讯作者发表在Nature Aging、Journal of Cell Biology、EMBO J、Cell Reports、PLoS Genetics、J Cell Sci、Mol Biol Cell等国际学术刊物。课题组通过建立相应的模式动物在体研究体系，力图从细胞内膜运输调控的视角拓展对膜性细胞器在细胞生理病理过程中的重要作用的认识，为发展靶向肠道病原微生物侵染的广谱策略提供新的见解，为研究衰老相关疾病以及评估抗衰老策略提供理论参考。

Anbing Shi (he/him)

Distinguished Professor, Huazhong University of Science and Technology

Department of Biochemistry and Molecular Biology

Phone: +86-27-83692608

Email: ashi@hust.edu.cn

Keywords: Endosome cell biology, small GTPase, membrane skeleton, and modeling human diseases in Caenorhabditis elegans

Currently serving as the Dean of the School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology; Director of the Cell Architecture Research Center, and Chair of the Department of Biochemistry and Molecular Biology. Dr. Shi obtained his Bachelor's degree from Nankai University and his Master's and Ph.D. degrees from Rutgers University–New Brunswick in the United States. Dr. Shi conducted postdoctoral training at Stanford University and returned to Huazhong University of Science and Technology in 2013 to pursue independent research.

Teaching undergraduate and graduate courses such as "Medical Cell and Molecular Biology," "Biochemistry and Molecular Biology," and "Genetics." He serves as the coordinator of the eight-year integrated course "Medical Cell and Molecular Biology" and is responsible for the graduate course "Basic Research Techniques in Metabolic Disease". He is currently the chief editor of the national planning textbook for medical graduate students, "Medical Molecular Biology," and the chief editor for medical graduate students, "Cell and Molecular Biology". He also serves as the associate editor of the national planning textbook for five-year undergraduate clinical medicine, "Medical Cell Biology".

The laboratory is devoted to investigating the fundamentals of endosome dynamics and its functions. The team employs multidisciplinary approaches, including genetic manipulation, super-resolution imaging, optogenetic control, and in vitro reconstitution to investigate dynamic aspects of endocytic physiology and pathology (regulation of Ras superfamily proteins activity, membrane skeleton dynamics, membrane transport regulatory network composition and functional modes), endosomal regulation of tissue aging, and endosomal regulation of host-pathogen interactions. Relevant findings have been published as corresponding authors in academic journals such as Nature Aging, Journal of Cell Biology, EMBO J, Cell Reports, PLoS Genetics, J Cell Sci, and Mol Biol Cell. The team is attempting to increase awareness of the vital roles of membranous organelles in cellular physiological and pathological processes through the development of in vivo research systems in model animals, with the focus being on the regulation of intracellular membrane trafficking. The research endeavors to gain new perspectives on developing thorough tactics to oppose the infiltration of intestinal microbes and offers an outline of the study of age-related diseases and the appraisal of anti-aging approaches.