鲁友明个人简介

1998年毕业于多伦多大学，获神经科学博士学位。2010年3月获聘中组部国家特聘专家，辞去美国路易斯安那州立大学新奥尔良医学中心BOLLINGER冠名终身正教授，全职在华中科技大学同济医学院工作至今。现任同济医学院副院长、教育部脑医学基础研究创新中心主任。

鲁友明教授长期致力于解析“记忆分子和环路机制”。他的主要学术贡献是提出了“靶向肿瘤分泌因子治疗阿尔茨海默病”的新理论。在Cell，Science，Nature Neuroscience和Neuron等期刊发表研究论文150篇，总引用超过13,000次，入选“爱思唯尔2014-2024年度”神经科学领域高被引中国学者，2021年中国神经科学学会“CST杰出神经科学家奖”。部分成果被诺贝尔生理学或医学奖得主John O´Keefe教授写入教科书。“记忆神经环路与分子机制”获2021年湖北省自然科学奖一等奖，基金委“记忆神经环路机制”创新研究群体，教育部首届“黄大年式教师团队”（牵头人）。科技部“神经环路结构与功能学科创新基地”（负责人）。主编中国普通高等教育“十四五”规划教材《生理学》和教育部 101 计划核心教材《神经系统》。

邮箱：lym@hust.edu.cn

代表论文（通讯和共同通讯）：

1. Li X, Tang X, Zeng J, Duan L, Hou Z, Li L, Guo Y, Chai C, Wang Y, Liu J, Wang Y, Zhu LQ, Lu Y. Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2. Cell 2026 (in press）

2. He A, Wang Y, Shen Y, Dong Z, Luo L, Ge X, Liu X, Mao Y, Zhang T, Li X, Li H, Jing W, Zhu L, Zhang Q, Lu Y. Allosteric activation of a cell-type specific GPR120 inhibits amyloid pathology of Alzheimer’s disease. Nature Aging 2025 2025 Dec 19. doi: 10.1038/s43587-025-01028-4.

3. Zhou Y, Li WL, Liu ZQ, Ai WQ, Kou JX, Fan HW, Han ZT, Hu YZ, Zhang HH, Jia JJ, Zeng Y, Guo ZY, Man HY, Lu Y, Liu D, Zhu LQ. Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons. Nature Neuroscience 2025 Nov 18. doi: 10.1038

4. Qin P, Zhao W, Zhou X, Guo Y, Li L, Liu Z, Shen X, Yang C, Tang X, Yu D, Zhu M, Wu S, Cheng L, Yang J, Li X, Li H, Zhu LQ, Jing W, Du HY, Liu D, Lu Y. A cell-type-specific epigenetic mechanism encodes social investigatory behavior via Lrhcn1 and Hcn1. Science Advances 2025 Jun 6;11(23): eadt5400. doi: 10.1126

5. Luo L, Jing W, Guo Y, Liu D, He A, Lu Y. A cell-type-specific circuit of somatostatin neurons in the habenula encodes antidepressant action in male mice. Nature Communications 2025 Apr 10;16(1):3417. doi: 10.1038

6. Li L, Guo Y, Jing W, Tang X, Zeng J, Hou Z, Song Y, He A, Li H, Zhu LQ, Lu Y, Li X. Cell-Type Specific Circuits in the Mammillary Body for Place and Object Recognition Memory. Advanced Science (2025) Feb 10:e2409397.

7. Zhang H, Lei M, Zhang Y, Li H, He Z, Xie S, Zhu L, Wang S, Liu J, Li Y, Lu Y, Ma C. Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release. Science Advances 10(20) (2024): eadi7024.

8. Li X, Yu H, Zhang B, Li L, Chen W, Yu Q, Huang X, Ke X, Wang Y, Jing W, Du H, Li H, Zhang T, Liu L, Zhu LQ, Lu Y. Molecularly defined and functionally distinct cholinergic subnetworks. Neuron 110(22) (2022):3774-3788.e7

9. He A, Zhang C, Ke X, Yi Y, Yu Q, Zhang T, Yu H, Du H, Li H, Tian Q, Zhu LQ, Lu Y. VGLUT3 neurons in median raphe control the efficacy of spatial memory retrieval via ETV4 regulation of VGLUT3 transcription. Science China Life Sciences. 65(8) (2022): 1590-1607

10. Li X, Chen W, Huang X, Jing W, Zhang T, Yu Q, Yu H, Li H, Tian Q, Ding Y, Lu Y. Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors. Molecular Neurodegeneration. 16(1) (2021): 73.

11. Li X, Chen W, Pan K, Li H, Pang P, Guo Y, Shu S, Cai Y, Pei L, Liu D, Afewerky HK, Tian Q, Zhu LQ, Lu Y. Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger-Westphal nucleus. Nature Neuroscience. 21(9) (2018): 1239-1250

12. Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ, Lu Y. A novel mechanism of memory loss in Alzheimer's disease mice via the degeneration of entorhinal-CA1 synapses. Molecular Psychiatry. 23(2) (2018): 199-210.

13. Zhu H, Yan H, Tang N, Li X, Pang P, Li H, Chen W, Guo Y, Shu S, Cai Y, Pei L, Liu D, Luo MH, Man H, Tian Q, Mu Y, Zhu LQ, Lu Y. Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nature Communications. 8(1) (2017): 1676.

14. Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu W, Zhu LQ, Wang JZ, Lu Y. EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. Neuron. 73(4) (2012): 774-788

15. Tu W, Xu X, Peng L, Zhong X, Zhang W, Soundarapandian MM, Balel C, Wang M, Jia N, Zhang W, Lew F, Chan SL, Chen Y, Lu Y. DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell. 140(2) (2010): 222-234