郭 峥

华中科技大学

同济医学院基础医学院医学遗传学系

基础医学院教授，博导

医学遗传系，主任

实验室网页：http://www.guozhenglab.net

联系地址：

湖北省武汉市硚口区航空路13号同济医学院形态学楼102室

邮箱: guozheng@hust.edu.cn

教育经历：

2004-2011, 中国科学院遗传与发育生物学研究所，发育生物学博士学位

2000-2004, 中央民族大学生命科学专业，理学学士

工作经历：

2016-至今,教授，华中科技大学同济医学院基础医学院

2011-2016,博士后，美国哥伦比亚大学医学院

实验室研究领域及内容:

主要研究领域为成体干细胞命运决定与组织稳态，近期重点聚焦：（1）肠道干细胞的分裂计数与命运切换机制，揭示TrxG/PcG拮抗介导的组蛋白修饰动态如何构建细胞内“分裂计数器”，从而按固定时序精确调控干细胞自我更新与子代分化比例；（2）干细胞不对称分裂的分子基础及其对干细胞数目和子代细胞命运的精确控制；（3）Notch/Wnt等信号通路在干细胞多能性维持与分化指定中的时空调控。研究以果蝇肠道和小鼠肠道为主要模型，结合遗传学、活体成像、单细胞与组学手段，从信号转导、表观遗传记忆到细胞命运切换多层面解析成体干细胞分化逻辑，为再生医学及以分化为导向的肿瘤干预提供新靶点。文章发表在 Nature, Developmental Cell, Nature Communications, Science Advance, PNAS, Cell Reports 和 Development 等国际著名杂志。

代表性研究论文：

1.Tong, D., Li, A., Jiang, Q., Yuan, Q., Liu, X., He, X., Liang, J., Han, Y., and Guo, Z.(2026). Intestinal stem cells count self-renewal divisions to switch multipotency. Nature. 10.1038/s41586-026-10814-y.

2.Shi, F., Qiao, L., Wu, Y., and Guo, Z.(2026). Kuzbanian expression levels dictate Notch signaling outcomes via interplay between cis- and trans-Delta. Development153. 10.1242/dev.204789.

3.Wu, Y., Yu, L., Yu, Y., Wu, S., Yuan, Q., Duan, W., Cai, S., Xiong, B., Lin, R., and Guo, Z.(2025). Drosophila and mouse intestinal stem cells are spatiotemporally specified by Notch suppression and Wnt activation. Sci Adv11, eady7272. 10.1126/sciadv.ady7272.

4.Qin, P., Wang, Q., Wu, Y., You, Q., Li, M., and Guo, Z.(2025). Age mosaic of gut epithelial cells prevents aging. Nature communications16, 6734. 10.1038/s41467-025-62043-y.

5.Li, A., Tong, D., Ohlstein, B., and Guo, Z.(2025). Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila. Proceedings of the National Academy of Sciences of the United States of America122, e2513015122. 10.1073/pnas.2513015122.

6.Zhang, S., Wu, S., Yao, R.N., Wei, X.Y., Ohlstein, B., and Guo, Z.(2024). Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in Drosophila. Developmental cell59. 10.1016/j.devcel.2023.11.016.

7.Gao, J., Zhang, S., Deng, P., Wu, Z., Lemaitre, B., Zhai, Z., and Guo, Z.(2024). Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion. Nature communications15, 3514. 10.1038/s41467-024-47465-4.

8.Wu, S., Yang, Y., Tang, R., Zhang, S., Qin, P., Lin, R., Rafel, N., Lucchetta, E.M., Ohlstein, B., and Guo, Z.(2023). Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold. Cell reports42, 112093. https://doi.org/10.1016/j.celrep.2023.112093.

9.Wu, S., Tang, R., Ohlstein, B., and Guo, Z.(2023). A live-imaging protocol for tracking intestinal stem cell divisions in the Drosophila melanogaster pupal midgut. STAR protocols4, 102749. 10.1016/j.xpro.2023.102749.

10.Tang, R., Qin, P., Liu, X., Wu, S., Yao, R., Cai, G., Gao, J., Wu, Y., and Guo, Z.(2021). Intravital imaging strategy FlyVAB reveals the dependence of Drosophila enteroblast differentiation on the local physiology. Communications biology4, 1223. 10.1038/s42003-021-02757-z.

11.Guo, Z., Lucchetta, E., Rafel, N., and Ohlstein, B. (2016). Maintenance of the adult Drosophila intestine: all roads lead to homeostasis. Current opinion in genetics & development40, 81-86. 10.1016/j.gde.2016.06.009.

12.Guo, Z., and Ohlstein, B. (2015). Stem cell regulation. Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency. Science350. 10.1126/science.aab0988.

13.Guo, Z., Driver, I., and Ohlstein, B. (2013). Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. The Journal of cell biology201, 945-961. 10.1083/jcb.201302049.

14.Guo, Z., and Wang, Z. (2009). The glypican Dally is required in the niche for the maintenance of germline stem cells and short-range BMP signaling in the Drosophila ovary. Development136, 3627-3635. 10.1242/dev.036939.

获得荣誉:

入选国家海外高层次人才计划

获得资助:

自然科学基金委重点项目（32630030）

自然科学基金委面上项目四项（31771625, 31970817,32271074,32470885）

实验室博士后获得自然科学基金委青年基金（31900618），国家博士后基金（2017M622408）

教授课程：

1001101细胞生物学Cell Biology(本科)

1001121医学遗传学Medical Genetics (本科、硕士)

510.543医学遗传学进展Advances in Medical Genetics (硕士)

510.805医学遗传学进展Advanced Medical Genetics (博士)

510.816 Dysfunction of Receptors and Ion Channels in Neurological Disease (博士)