郭 峥
华中科技大学
同济医学院基础医学院医学遗传学系
联系地址：
湖北省武汉市硚口区航空路13号同济医学院形态学楼102室
联系方式：
电话: 86(27) 13545037970
邮箱: guozheng@hust.edu.cn
教育与工作经历：
2016-至今, 教授、医学遗传学系系主任 华中科技大学同济医学院基础医学院2011-2016, 博士后，美国哥伦比亚大学医学院遗传与发育生物学系。
2004-2011, 中国科学院遗传与发育生物学研究所，发育生物学博士学位
实验室研究领域及内容:
目前实验室利用果蝇与小鼠为模式动物，对肠道干细胞的多功能分化进行深入研究，以期理解干细胞分化的内在生理逻辑和分子基础，以达到对癌症以分化为导向的转化医学治疗。主要研究内容为：1）肠道表皮干细胞数目的决定机制；2）肠道表皮干细胞位置的决定机制；3）肠道干细胞分化过程中Notch信号激活强弱的控制机制；4)肠道干细胞多功能分化的子代细胞比例控制机制。文章发表在Science, Developmental Cell, PNAS, Nature Communications, Science Advances, Cell Reports, Development等国际著名杂志。
研究论文：
1. Wu, Y., Yu, L., Yu, Y., Wu, S., Yuan, Q., Duan, W., Cai, S., Xiong, B., Lin, R., and Guo, Z. (2025). Drosophila and mouse intestinal stem cells are spatiotemporally specified by Notch suppression and Wnt activation. Sci Adv 11, eady7272. 10.1126/sciadv.ady7272.
2. Qin, P., Wang, Q., Wu, Y., You, Q., Li, M., and Guo, Z. (2025). Age mosaic of gut epithelial cells prevents aging. Nature communications 16, 6734. 10.1038/s41467-025-62043-y.
3. Li, A., Tong, D., Ohlstein, B., and Guo, Z. (2025). Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila. Proceedings of the National Academy of Sciences of the United States of America 122, e2513015122. 10.1073/pnas.2513015122.
4. Zhang, S., Wu, S., Yao, R.N., Wei, X.Y., Ohlstein, B., and Guo, Z. (2024). Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in Drosophila. Developmental cell 59. 10.1016/j.devcel.2023.11.016.
5. Gao, J., Zhang, S., Deng, P., Wu, Z., Lemaitre, B., Zhai, Z., and Guo, Z. (2024). Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion. Nature communications 15, 3514. 10.1038/s41467-024-47465-4.
6. Wu, S., Yang, Y., Tang, R., Zhang, S., Qin, P., Lin, R., Rafel, N., Lucchetta, E.M., Ohlstein, B., and Guo, Z. (2023). Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold. Cell reports 42, 112093. https://doi.org/10.1016/j.celrep.2023.112093.
7. Wu, S., Tang, R., Ohlstein, B., and Guo, Z. (2023). A live-imaging protocol for tracking intestinal stem cell divisions in the Drosophila melanogaster pupal midgut. STAR protocols 4, 102749. 10.1016/j.xpro.2023.102749.
8. Tang, R., Qin, P., Liu, X., Wu, S., Yao, R., Cai, G., Gao, J., Wu, Y., and Guo, Z. (2021). Intravital imaging strategy FlyVAB reveals the dependence of Drosophila enteroblast differentiation on the local physiology. Communications biology 4, 1223. 10.1038/s42003-021-02757-z.
9. Guo, Z., Lucchetta, E., Rafel, N., and Ohlstein, B. (2016). Maintenance of the adult Drosophila intestine: all roads lead to homeostasis. Current opinion in genetics & development 40, 81-86. 10.1016/j.gde.2016.06.009.
10. Guo, Z., and Ohlstein, B. (2015). Stem cell regulation. Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency. Science 350. 10.1126/science.aab0988.
11. Guo, Z., Driver, I., and Ohlstein, B. (2013). Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. The Journal of cell biology 201, 945-961. 10.1083/jcb.201302049.
12. Guo, Z., and Wang, Z. (2009). The glypican Dally is required in the niche for the maintenance of germline stem cells and short-range BMP signaling in the Drosophila ovary. Development 136, 3627-3635. 10.1242/dev.036939.
获得荣誉：
第十三批中组部“千人计划”青年项目。
获得资助:
自然科学基金委面上项目四项，实验室博士后获得自然科学基金委青年基金一项，国家博士后基金一项。
教授课程：
1001101 细胞生物学Cell Biology (本科)
1001121 医学遗传学Medical Genetics (本科、硕士)
510.543 医学遗传学进展Advances in Medical Genetics (硕士)
510.805 医学遗传学进展Advanced Medical Genetics (博士)
510.816 Dysfunction of Receptors and Ion Channels in Neurological Disease (博士)
在研课题：
1. Determine the mechanism of the “differentiation toggle” in Drosophila ISCs.
2. Determine the mechanism of high-low Notch signaling establishment.
3. To determine whether mammalian intestinal stem cells use the same bidirectional Notch signaling to regulate multipotency.
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