李传洲

专业方向：神经退行性疾病机理

• 个人简介：2007年武汉大学生科院获学士学位；2012年武汉大学获得细胞生物学博士学位；2013-2018年澳大利亚昆士兰脑研究所从事博士后研究。2018年4月入职基础医学院医学遗传系，博士生导师，研究方向为神经退行性疾病致病机理。包括：1）阿尔茨海默病（AD）中微管结合蛋白Tau和激酶Fyn的相互调控机理；2）Tau蛋白在胞体树突中形成神经纤维缠结的机制；3）FUS基因突变导致肌萎缩侧索硬化（ALS/渐冻症）的致病机理。近年来在Neuro-Oncology、Biomark Res、Ann Clin Transl Neur、Front Neurol、Front Neurosci、Front Genet发表通讯作者论文；唯一第一作者J Azheimers Dis、EMBO J封面文章、Nat. Rev. Drug. Discov封面文章；获得华中科技大学自主创新基金、国家自然科学基金青年项目和面上项目支助；担任‘Oncogene’‘Journal of Neurochemistry’‘Pharmaceutical Research’ ‘Scientific Reports’‘Neural Regeneration Research’ ‘International Journal of Biological Sciences’ ‘Biological research’ ‘Aging’ ‘Cellular and Molecular Life Sciences’ ‘Front. Neuro’ ‘Front. Neurosci.’等杂志评审专家，Gene Expression杂志编委，Current Medical Science杂志青年编委；多种教育部省科技厅项目论文评审专家以及101教育部医学分子遗传学教材编委。

联系方式：chuanzhouli@hust.edu.cn

地址：同济医学院基础医学院2号楼1220室

Liu, D., H. Zhu, L. Cheng, R. Li, X. Ma, J. Wang, J. Wang, S. Zhang, Y. Li, K. Shu, X. Yu andC. Li(2023). "Hypoxia induced Galectin-8 maintains stemness in glioma stem cells via autophagy regulation."Neuro-Oncology.通讯

Liu, D., Zhu, H., andLi, C.(2023). Galectins and galectin-mediated autophagy regulation: new insights into targeted cancer therapy.Biomark Res11, 22.通讯

Li, Y., J. Xu, Y. Xu,C. Li, Y. Wu and Z. Liu (2023). "Clinical, genetic, and molecular characteristics in a central-southern Chinese cohort of genetic leukodystrophies."Ann Clin Transl Neurol.共通讯

Liang, Z., Y. Wu,C. Liand Z. Liu (2023). "Clinical and genetic characteristics in a central-southern Chinese cohort of early-onset Alzheimer's disease."Front Neurol14: 1119326.共通讯

Zhao, L., F. Meng, Y. Li, S. Liu, M. Xu, F. Chu,C. Li,X. Yang and L. Luo (2023). "Multivalent Nanobody Conjugate with Rigid, Reactive Oxygen Species Scavenging Scaffold for Multi-Target Therapy of Alzheimer's Disease."Adv Mater: e2210879.

Zhang J, Hu C, Xie X, Qi L, Li C*, Li S*. (2023). Immune Checkpoint Inhibitors in HBV-Caused Hepatocellular Carcinoma Therapy.Vaccines.; 11(3):614.共通讯

Chu, F., Xu, J., Wang, Y., Li, Y., Wang, Y., Liu, Z., andLi, C. (2022). Novel mutations in GJB1 trigger intracellular aggregation and stress granule formation in X-linked Charcot-Marie-Tooth Disease.Front Neurosci16, 972288.通讯

Tian, H., Chu, F., Li, Y., Xu, M., Li, W., andLi, C. (2022). Synergistic effects of rare variants of ARHGAP31 and FBLN1 in vitro in terminal transverse limb defects.Front Genet13, 946854.通讯

Wang, W., Li, J., Tan, J., Wang, M., Yang, J., Zhang, Z.M.,Li, C., Basnakian, A.G., Tang, H.W., Perrimon, N., and Zhou, Q. (2021). Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.Nat Commun12, 476.

Polanco, J.C., Hand, G.R., Briner, A.,Li, C., and Gotz, J. (2021). Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol.Acta Neuropathol141, 235-256.

余裕龙,周珂如,李传洲, and陈娟(2020).精神分裂症断裂基因１参与线粒体动力学调控的研究进展.华中科技大学学报（医学版）49, 98.

Chen, Y., Sun, T., Niu, Y., Wang, D., Xiong, Z.,Li, C., Liu, K., Qiu, Y., Sun, Y., Gong, J., Wang, T., Wang, S., Xu, H., and Liu, J. (2020). Correlations Among Genotype and Outcome in Chinese Male Patients With Congenital Hypogonadotropic Hypogonadism Under HCG Treatment.J Sex Med17, 645-657.

Li, C., Briner, A., and Gotz, J. (2019). The search for improved animal models of Alzheimer's disease and novel strategies for therapeutic intervention.Future Med Chem11, 1853-1857.

Li, C. and J. Götz, Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.J Alzheimers Dis,2018. 64(1): p. 205-221.（受Fyn调控的新型Tau酪氨酸激酶Pyk2；唯一第一作者；杂志网页推荐文章；影响因子3.92）

Polanco, J.C.,Li, C.Durisic, N. Sullivan, R. Götz, J. et al., Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons.Acta Neuropathol Commun, 2018. 6(1): p. 10.（影响因子5.414）

Polanco, J.C.,Li, C., Bodea L.G., Marmol, R.M., Meunier, F., and Götz, J. (2017) Amyloid-beta and tau complexity - towards improved biomarkers and targeted therapies.Nat Rev Neurol, 2018. 14(1): p. 22-39.（β淀粉样蛋白和tau的多态性—更好生物标志物和靶向治疗；影响因子20.2）

Li, C.and J. Gotz (2017). "Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation."EMBO Journal36(21): 3120-3138.（阿尔兹海默症中Fyn介导的局部蛋白质合成促进了Tau在胞体树突的聚集；唯一第一作者；影响因子9.792；权威学术论坛Alzforum对此发表长篇评论；杂志封面）

Li, C. and J. Gotz (2017). "Tau-based therapies in neurodegeneration: opportunities and challenges."Nat Rev Drug Discov16(12): 863-883.（以Tau为基础的神经退行性疾病的多元化靶向治疗；唯一第一作者；影响因子57）

Xia, D.,Li, C., and Götz, J. (2015). "Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines."Biochim. Biophys. Acta. 1852(5): 913-924.（影响因子5.725）

Li, C., Wang, L., and Zheng, L. (2012). "Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrol."Invest. Ophthalmol. Vis. Sci.53(6): 3241-3249. (眼科研究型杂志中排名第一;影响因子3.427）

Li, C., Wang, L., Huang, K., and Zheng, L. (2012). "Inhibition of poly(ADP-ribose) polymerase inhibits ischemia/reperfusion induced neurodegeneration in retina via suppression of endoplasmic reticulum stress."Biochem. Biophys. Res. Commun. 423(2):276-281.（影响因子：2.5559）

Wang, L.,Li, C., Guo, H., Kern, T.S., Huang, K., and Zheng, L. (2011). Curcumin inhibits neuronal and vascular degeneration in retina after ischemia and reperfusion injury.PLoS ONE6(8):e23194.（影响因子：2.766）

Sullivan, M.A., Li, J.,Li, C., Vilaplana, F., Stapleton, D., Gray-Weale, A.A., Bowen, S., Zheng, L., and Gilbert ,R.G. (2011). Molecular structural differences between type-2-diabetic and healthy glycogen.Biomacromolecules12(6):1983-1986.（影响因子：5.246）

Gong, H., Zhang, X., Cheng, B., Sun, Y.,Li, C., Li, T., Zheng, L., and Huang, K. (2013). "Bisphenol a Accelerates Toxic Amyloid Formation of Human Islet Amyloid Polypeptide: A Possible Link between Bisphenol a Exposure and Type 2 Diabetes."PLoS One8, no. 1:e54198.（影响因子：2.766）

Cheng, B., Liu, X., Gong, H., Huang, L., Chen, H., Zhang, X.,Li, C., Yang, M., Ma, B., Jiao, L., Zheng, L. and Huang, K. (2011). Coffee Components Inhibit Amyloid Formation of Human Islet Amyloid Polypeptide in Vitro: Possible Link between Coffee Consumption and Diabetes Mellitus.J. Agric. Food Chem.59(24):13147-13155.（影响因子：3.154）

Zhang, X., Cheng, B., Gong, H.,Li, C., Chen, H., Zheng, L., and Huang, K. (2011). Porcine islet amyloid polypeptide fragments are refractory to amyloid formation.FEBS Lett585(1):71-77.（影响因子：2.999）