个人简介

陈宏生，硕士生导师。2013年毕业于华中科技大学，获理学学士学位。2018年毕业于华中科技大学同济医学院，获医学博士学位。2018至2023年，于华中科技大学基础医学院进行博士后研究。2023年4月入职基础医学院药理学系。

主要从事创伤后应激障碍、抑郁症、焦虑症等负性情感障碍的分子机制和药物靶点研究。以第一、共同第一作者在Science Advances、Biological Psychiatry、Brain Behavior and Immunity、Current Opinion in Neurobiology等杂志发表论文多篇。作为负责人主持国家自然科学基金2项，中国博士后科学基金面上项目1项。相关工作获华夏医学科技进步奖（6/10）。

联系方式：QQ：421206625

E-mail：chenhongsheng1991@163.com

主要研究项目：

1. 国家自然科学基金面上基金项目，82473902，氯胺酮长效抗抑郁作用新机制：Neurobeachin驱动的突触后膜受体循环途径，主持

2. 国家自然科学基金青年科学基金项目，81903593，前额皮层LncRNA-GM2694/HSP70通路调控抑郁症的机理研究，主持

3. 中国博士后科学基金面上资助，2019M652657，LncRNA GM2694损伤突触可塑性介导抑郁症发病，主持

4. 华中科技大学技术创新基金，AMPA受体的膜稳定性对创伤后应激障碍的作用及机制，主持

近5年代表性学术论文:

1. Hong-Sheng Chen^(#), Fang Wang, Jian-Guo Chen^(*).Epigenetic mechanisms in depression: Implications for pathogenesis and treatment.Curr Opin Neurobiol.2024 Apr:85:102854.

2. Kai-Yu Zheng^(#), Bo Gao^(#), Hua-Jie Wang,Jin-Gang He,Hong-Sheng Chen, Zhuang-Li Hu, Li-Hong Long, Jian-Guo Chen^(*), Fang Wang^(*). Melatonin Ameliorates Depressive-Like Behaviors in Ovariectomized Mice by Improving Tryptophan Metabolism via Inhibition of Gut Microbe Alistipes Inops.Adv Sci (Weinh).2024 Sep;11(34):e2309473.

3. Ji Wang^(#),Hong-Sheng Chen^(#), Hou-Hong Li, Hua-Jie Wang, Ruo-Si Zou, Xiao-Jia L, Jie Wang , Bin-Bin Nie, Jin-Feng Wu, Shuang Li , Bao-Ci Shan, Peng-Fei Wu, Li-Hong Long, Zhuang-Li Hu^(*), Jian-Guo Chen^(*), Fang Wang^(*).Microglia-dependent excessive synaptic pruning leads to cortical underconnectivity and behavioral abnormality following chronic social defeat stress in mice.Brain Behav Immun.2023 Mar:109:23-36.

4. Hou-Hong Li^(#), Yang Liu^(#),Hong-Sheng Chen, Ji Wang, Yu-Ke Li, Yang Zhao, Rui Sun, Jin-Gang He, Fang Wang^(*), Jian-Guo Chen^(*).PDGF-BB-Dependent Neurogenesis Buffers Depressive-Like Behaviors by Inhibition of GABAergic Projection from Medial Septum to Dentate Gyrus.Adv Sci (Weinh). 2023 Aug;10(22):e2301110.

5. Shao-Qi Zhang^(#), Qiao Deng^(#), Qi Zhu^(#), Zhuang-Li Hu, Li-Hong Long, Peng-Fei Wu,Jin-Gang He,Hong-Sheng Chen,Zhenyu Yue, Jia-Hong Lu^(*), Fang Wang^(*), Jian-Guo Chen^(*).Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression.Cell Discovery.2023 Aug 29;9(1):90.

6. Jia-Jing Lu^(#); Peng-Fei Wu^(#);Jin-Gang He; Yu-Ke Li; Li-Hong Long; Xia-Ping Yao; Jia-Hao Yang;Hong-Sheng Chen; Xiang-Nan Zhang; Zhuang-Li Hu; Zhong Chen; Wang Fang^(*); Chen Jianguo^(*). BNIP3L/NIX-mediated mitophagy alleviates passive stress-coping behaviors induced by tumor necrosis factor-α.Molecular Psychiatry,2023 Mar 13. doi: 10.1038/s41380-023-02008-z

7. Hong-Sheng Chen^(#), Ji Wang^(#), Hou-Hong Li, Xiao Wang, Shao-Qi Zhang, Tan Deng, Yu-Ke Li, Ruo-Si Zou, Hua-Jie Wang, Rui Zhu, Wen-Long Xie, Gang Zhao^(*), Fang Wang^(*), Jian-Guo Chen^(*).Long noncoding RNA Gm2694 drives depressive-like behaviors in male mice by interacting with GRP78 to disrupt endoplasmic reticulum homeostasis.Science Advances. 2022 Dec 2;8(48):eabn2496.

8. Kuan Li^(#),Hong-Sheng Chen^(#), Di Li, Hou-Hong Li, Ji Wang, Lei Jia, Peng-Fei Wu, Li-Hong Long, Zhuang-Li Hu, Jian-Guo Chen^(*), Fang Wang^(*).SAR405, a Highly Specific VPS34 Inhibitor, Disrupts Auditory Fear Memory Consolidation of Mice via Facilitation of Inhibitory Neurotransmission in Basolateral Amygdala.Biological Psychiatry. 2019 Feb 1;85(3):214-225.