郭峥

华中科技大学

同济医学院基础医学院医学遗传学系

• 基础医学院教授，博导

• 医学遗传系，主任

• 实验室网页：http://www.guozhenglab.net

联系地址：

湖北省武汉市硚口区航空路13号同济医学院形态学楼102室

联系方式：

电话:86(27)13545037970

邮箱: guozheng@hust.edu.cn

教育经历：

2004-2011,中国科学院遗传与发育生物学研究所，发育生物学博士学位

2000-2004， 中央民族大学生命科学专业，理学学士

工作经历：

2016-至今,教授、医学遗传学系系主任华中科技大学同济医学院基础医学院

2011-2016,博士后，美国哥伦比亚大学医学院遗传与发育生物学系。

实验室研究领域及内容:

目前实验室利用果蝇为模式动物，对肠道干细胞的多功能分化进行深入研究，以期理解干细胞分化的内在生理逻辑和分子基础，以达到对癌症以分化为导向的转化医学治疗。主要研究内容为：1）肠道表皮干细胞数目的决定机制；2）肠道表皮干细胞位置的决定机制；3）肠道干细胞分化过程中Notch信号激活强弱的控制机制；4)肠道干细胞多功能分化的子代细胞比例控制机制。文章发表在Science,DevelopmentalCell，NatureCommunications，The Journal ofCell Biology,CellReports，Development,CommunicationsBiology等国际著名杂志。

研究论文：

1.Zhang, S., Wu, S., Yao, R.N., Wei, X.Y., Ohlstein, B., andGuo, Z.(2024). Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in. Developmental cell59. 10.1016/j.devcel.2023.11.016.

2.Gao, J., Zhang, S., Deng, P., Wu, Z., Lemaitre, B., Zhai, Z., andGuo, Z.(2024). Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion. Nature communications15, 3514. 10.1038/s41467-024-47465-4.

3.Wu, S., Yang, Y., Tang, R., Zhang, S., Qin, P., Lin, R., Rafel, N., Lucchetta, E.M., Ohlstein, B., andGuo, Z.(2023). Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold. Cell reports42, 112093. https://doi.org/10.1016/j.celrep.2023.112093.

4.Wu, S., Tang, R., Ohlstein, B., andGuo, Z.(2023). A live-imaging protocol for tracking intestinal stem cell divisions in the Drosophila melanogaster pupal midgut. STAR protocols4, 102749. 10.1016/j.xpro.2023.102749.

5.Wang, B., Gao, J., Jiang, J., Hu, Z., Hjort, K.,Guo, Z., and Wu, Z. (2021). Liquid Metal Microscale Deposition enabled High Resolution and Density Epidermal Microheater for Localized Ectopic Expression inDrosophila. Advanced Materials Technologies, 2100903. 10.1002/admt.202100903.

6.Tang, R., Qin, P., Liu, X., Wu, S., Yao, R., Cai, G., Gao, J., Wu, Y., andGuo, Z.(2021). Intravital imaging strategy FlyVAB reveals the dependence of Drosophila enteroblast differentiation on the local physiology. Communications biology4, 1223. 10.1038/s42003-021-02757-z.

7.Guo, Z., Lucchetta, E., Rafel, N., and Ohlstein, B. (2016). Maintenance of the adult Drosophila intestine: all roads lead to homeostasis. Current opinion in genetics & development40, 81-86. 10.1016/j.gde.2016.06.009.

8.Guo, Z., and Ohlstein, B. (2015). Stem cell regulation. Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency. Science350. 10.1126/science.aab0988.

9.Guo, Z., Driver, I., and Ohlstein, B. (2013). Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. The Journal of cell biology201, 945-961. 10.1083/jcb.201302049.

10.Guo, Z., and Wang, Z. (2009). The glypican Dally is required in the niche for the maintenance of germline stem cells and short-range BMP signaling in the Drosophila ovary. Development136, 3627-3635. 10.1242/dev.036939.

获得荣誉：

第十三批中组部“千人计划”青年项目。

获得资助:

自然科学基金委面上项目三项，实验室博士后获得自然科学基金委青年基金一项，国家博士后基金一项。

教授课程：

1001101细胞生物学Cell Biology(本科)

1001121医学遗传学Medical Genetics (本科、硕士)

510.543医学遗传学进展Advances in Medical Genetics (硕士)

510.805医学遗传学进展Advanced Medical Genetics (博士)

510.816 Dysfunction of Receptors and Ion Channels in Neurological Disease (博士)

在研课题：

1. Determine the mechanism of the“differentiation toggle” in Drosophila ISCs.

2.Determine the mechanism of high-low Notch signaling establishment.

3.To determine whether mammalian intestinal stem cells use the same bidirectional Notch signaling to regulate multipotency.