何然

华中科技大学同济医学院 副教授

通讯地址：湖北省武汉市汉口航空路13号

邮编：430030

电话：18523010609

教育经历：

2012／09－2016／12，南方医科大学，博士

2011/ 06－2012/ 08，香港理工大学，硕士

2008／02－2010／12，新西兰奥塔哥大学，学士

工作经历：

2017/09至今，华中科技大学同济医学院 副教授

主要荣誉：

2017年中国免疫学会青年学者奖

2016年重庆市科协首届自然科学优秀论文奖

主要论文：

He R, Hou S, Liu C, Zhang A, Bai Q, Han M, Yang Y, Wei G, Shen T, Yang X, Xu L, Chen X, Hao Y, Wang P, Zhu C, Ou J, Liang H, Ni T, Zhang X, Zhou X, Deng K, Chen Y, Luo Y, Xu J, Qi H, Wu Y, Ye L. Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection. Nature 2016 Aug 2;537(7620):412-428.

Zhao L*, He R*, Long H*, Guo B*, Jia Q, Qin D, Liu SQ, Wang Z, Xiang T, Zhang J, Tan Y, Huang J, Chen J, Wang F, Xiao M, Gao J, Yang X, Zeng H, Wang X, Hu C, Alexander PB, Symonds ALJ, Yu J, Wan Y, Li QJ, Ye L, Zhu B. Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells. Nature Medicine 2018 Oct;24(10):1536-1544.

*co-first author

He R, Yang X, Liu C, Chen X, Wang L, Xiao M, Ye J, Wu Y, Ye L. Efficient control of chronic LCMV infection by CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model. Cellular and Molecular Immunology 2018 Sep;15(9):815-826.

Xia Y, Lan J, Yang J, Yuan S, Xie X, Du Q, Du H, Nie W, Jiang B, Zhao L, Cai Z, Zhang X, Xiong Y, Li Y, He R*, Tao J*. Saturated fatty acid-induced neutrophil extracellular traps contribute to exacerbation and biologic therapy resistance in obesity-related psoriasis. Cellular and Molecular Immunology 2025 Jun;22(6):597-611.

*co-responding author

Du Q, Ning N, Zhao X, Liu F, Zhang S, Xia Y, Li F, Yuan S, Xie X, Zhu M, Huang Z, Tang Z, Wang J, He R*, Yang XP*. Acylglycerol kinase inhibits macrophage anti-tumor activity via limiting mtDNA release and cGAS-STING-type I IFN response. Theranostics. 2025 Jan 1;15(4):1304-1319. doi: 10.7150/thno.101298.

*co-responding author

Xiao M, Xie L, Cao G, Lei S, Wang P, Wei Z, Luo Y, Fang J, Yang X, Huang Q, Xu L, Guo J, Wen S, Wang Z, Wu Q, Tang J, Wang L, Chen X, Chen C, Zhang Y, Yao W, Ye J, He R*, Huang J*, Ye L*. CD4+ T-cell epitope-based heterologous prime-boost vaccination potentiates antitumor immunity and PD-1/PD-L1 immunotherapy. Journal for ImmunoTherapy of Cancer 2022;0:e004022. doi:10.1136/.

*co-responding author

Li, Lin; Xia, Yuting; Yuan, Shijie; Li, Fei; Xie, Xiaorong; Luo, Yuan; Yang, Xiang-Ping; He, Ran; Iron deprivation restrains the differentiation and pathogenicity of T helper 17 cell, Journal of Leukocyte Biology 2021, 110(6): 1057-1067

Luo Y, Li D, Xie L, Lei S, Chen X, Wang C, Yao D, Li L, Fang J, Chen C, Yuan S, Li F, Xie X, Zhang Y, Li Z, Hu L, Tang J, Ye L, Wei Z, He R. EZH2 restricts Tcf7 DNA methylation and promotes TFH differentiation during acute viral infection. Front Immunol. 2022 Aug 15;13:942465. doi: 10.3389/fimmu.2022.942465.

Zhao X, Xia M, Peng Z, Du Q, Liu Y, Xia Y, Lv P, Zhang X, Yuan S, Xie X, Wang J, Sun S, Yang XP, He R. TFEB Phase Separation Mediates the Amelioration Effect of Intermittent Fasting on Inflammatory Colitis. Inflammation. 2024 Dec 27. doi: 10.1007/s10753-024-02202-3. Epub ahead of print.

主要科研项目：

1. 国家自然科学基金面上项目：慢性病毒感染中TCF-1对CD8 T细胞耗竭的调控作用及机制研究（81871248）主持

2. 国家自然科学基金面上项目：α-氨基丁酸调控肿瘤相关巨噬细胞极化的机制研究（32070894）主持

3. 国家重点研发计划, 2020YFA0804400, 胆汁酸肝肠循环对肠道组织损伤修复的调控机制, 课题骨干

4. 国家重点研发计划，2023YFC2308602，传染病免疫耗竭期的临床诊治方案研究，课题骨干

联系方式：ranhecl13@163.com