Hu W, Wang Z, Zhang H, Mahaman YAR, Huang F, Meng D, Zhou Y, Wang S, Jiang N, Xiong J, Westermarck J, Lu Y, Wang J, Wang X, Shentu Y, Liu R*. Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling. Neurotherapeutics. 2022 Mar 14. doi: 10.1007/s13311-022-01204-z. (影响因子7.6)
Zhou Y, Liu X, Ma S, Zhang N, Yang D, Wang L, Ye S, Zhang Q, Ruan J, Ma J, Wang S, Jiang N, Zhao Z, Zhao S, Zheng C, Fan X, Gong Y, Abdoul Razak MY, Hu W, Pan J, Wang X, Fan J, Li J, Liu R*, Shentu Y*. ChK1 activation induces reactive astrogliosis through CIP2A/PP2A/STAT3 pathway in Alzheimer's disease. FASEB J. 2022 Mar;36(3):e22209.
Zhang H, Yang M, Wang X, Wei H, Du M, Wang M, Wang J, Chen Z, Peng C*, Liu R*. Zinc induces reactive astrogliosis through ERK dependent activation of Stat3 and promotes synaptic degeneration. J Neurochem. 2021 Dec;159(6):1016-1027.
Zhou Y, Yang D, Chen H, Zheng C, Jiang H, Liu X, Huang X, Ye S, Song S, Jiang N, Zhao Z, Ma S, Ma J, Huang K, Chen C, Fan X, Gong Y, Wang X, Fan J, Liu R*, Shentu Y*. Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice. FASEB J. 2020;34(12):16414-16431.
O'Connor M, Shentu YP, Wang G, Hu WT, Xu ZD, Wang XC, Liu R*, Man HY*. Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease. iScience. 2020 Aug 15;23(9):101465. doi: 10.1016/j.isci.2020.101465.
Wei H, Zhang HL, Wang XC, Xie JZ, An DD, Wan L, Wang JZ, Zeng Y, Shu XJ, Westermarck J, Lu YM, Ohlmeyer M*, Liu R*. Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models. Neurotherapeutics. 2020 Feb 24. doi: 10.1007/s13311-020-00841-6. (影响因子7.6)
Shentu YP, Hu WT, Zhang Q, Huo Y, Liang JW, Liuyang ZY, Zhou H, Wei H, Ke D,Wang XC, Wang JZ, Man HY, Westermarck J, Liu R*. CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits. Neurobiol Aging. 2019;75:198-208.
Shentu YP*, Hu WT, Liang JW, Liuyang ZY, Wei H, Qun W, Wang XC, Wang JZ, Westermarck J, Liu R*. Genistein Decreases APP/tau Phosphorylation and Ameliorates Aβ Overproduction Through Inhibiting CIP2A. Curr Alzheimer Res. 2019;16(8):732-740.
Shentu YP, Huo Y, Feng XL, Gilbert J, Zhang Q, Liuyang ZY, Wang XL, Wang G, Zhou H, Wang XC, Wang JZ, Lu YM, Westermarck J, Man HY*, Liu R*. CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease. Cell Rep. 2018 Jul 17;24(3):713-723. doi: 10.1016/j.celrep.2018.06.009.(F1000Prime推荐论文,影响因子9.4)
Tuo QZ, Liuyang ZY, Lei P, Yan X, Shentu YP, Liang JW, Zhou H, Pei L, Xiong Y, Hou TY, Zhou XW, Wang Q, Wang JZ, Wang XC, Liu R*. Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke. Cell Death Dis. 2018 Aug 29;9(9):870. (影响因子8.46)
Liang JW, Fang ZY, Huang Y, Liuyang ZY, Zhang XL, Wang JL, Hui W, Wang JZ, Wang XC, Zeng J*, Liu R*. Application of Weighted Gene Co-Expression Network Analysis to Explore the Key Genes in Alzheimer's Disease. J Alzheimers Dis. 2018 Aug 16. doi: 10.3233/JAD-180400.
Zhou H, Guo Y, Li X, Liuyang ZY, Shentu YP, Jing XP, Liang JW, Zhou XW, Wang XC, Wang JZ, Zeng J*, Liu R*. Long-term Helicobacter pylori Infection Does Not Induce Tauopathy and Memory Impairment in SD Rats. J Huazhong Univ Sci Technol[Med Sci]2017. 37(6):823-827.
Tuo QZ, Lei P*, Jackman KA, Li XL, Xiong H, Li XL, Liuyang ZY, Roisman L, Zhang ST, Ayton S, Wang Q, Crouch PJ, Ganio K, Wang XC, Pei L, Adlard PA, Lu YM, Cappai R, Wang JZ, Liu R*, Bush AI*. Tau-mediated iron export prevents ferroptotic damage after ischemic stroke. Mol Psychiatry. 2017 Nov;22(11):1520-1530. doi:10.1038/mp.2017.171. (ESI高被引论文, 影响因子15.9)
Qiu M, Shentu YP, Zeng J, Wang XC, Yan X, Zhou XW, Jing XP, Wang Q, Man HY, Wang JZ, Liu R*. Zinc mediates the neuronal activity-dependent anti-apoptotic effect. PLoS One. 2017;12(8):e0182150.
Sun XY, Tuo QZ, Liuyang ZY, Xie AJ, Feng XL, Yan X, Qiu M, Li S, Wang XL, Cao FY, Wang XC, Wang JZ*, Liu R*. Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation. Cell Death Dis. 2016 Nov 3;7(11):e2449. (影响因子8.46)
Xiong Y, Luo DJ, Wang XL, Qiu M, Yang Y, Yan X, Wang JZ, Ye QF, Liu R*. Zinc binds to and directly inhibits protein phosphatase 2A in vitro. Neurosci Bull.2015 Jun;31(3):331-7.
Wang XL, Xiong Y, Yang Y, Tuo QZ, Wang XC, Chen R, Tian Q, Zhang ZP, Yan X, Yang ZY, Wang JZ*, Liu R*. A novel tacrine-dihydropyridine hybrid (-)SCR1693 induces tau dephosphorylation and inhibits Aβ generation in cells. European Journal of Pharmacology. 2015, 754: 134-139
Wang XL, Zeng J, Yang Y, Xiong Y, Zhang ZH, Qiu M, Yan X, Sun XY, Tuo QZ, Liu R*, Wang JZ*. Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3β. J Alzheimers Dis. 2015;43(1):153-65.
Wang XL, Zeng J, Feng J, Tian YT, Liu YJ, Qiu M, Yan X, Yang Y, Xiong Y, Zhang ZH, Wang Q, Wang JZ*, Liu R*. Helicobacter pylori filtrate impairs spacial learning and memory in rat and increases β-amyloid by enhancing expression of presenilin-2. Frontiers in Aging Neuroscience, 11 April 2014 | doi: 10.3389/fnagi.2014.00066
Yang Y, Jing XP, Zhang SP, Gu RX, Tang FX, Wang XL, Xiong Y, Qiu M, Sun XY, Ke D, Wang JZ, Liu R*. High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling. PLoS One. 2013;8(1):e55384.
Xiong Y, Jing XP, Zhou XW, Wang XL, Yang Y, Sun XY, Qiu M, Cao FY, Lu YM, Liu R*, Wang JZ*. Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging. 2013 Mar;34(3):745-56.
Sun XY, Wei YP, Xiong Y, Wang XC, Xie AJ, Wang XL, Yang Y, Wang Q, Lu YM, Liu R*, Wang JZ. Synaptic released zinc promotes tau hyperphosphorylation by inhibition of PP2A. J Biol Chem.2012,287(14):11174-11182.
Liu R, Zhou XW, Tanila H, Bjorkdahl C, Wang JZ, Guan ZZ, Cao Y, Gustafsson JA,Winblad B, Pei JJ. Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. J Cell Mol Med. 2008,12(1):241-57.
Liu R, Zeng J, Zhou XW, Pei JJ, Wang JZ. Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation. Frontiers of Medicine in China.2008,2,235-238.
Liu R, Pei JJ,Wang XC,Zhou XW, Tian Q, Winblad B,Wang JZ. Anoxia induces tau dephosphorylation through protein phosphatase-2A activation in rat brain slices. J Neurochem 2005,Sep;94(5):1225-1234.
主要科研项目:
2021-2025 国家自然科学基金 550,000 RMB Tau病变活化小胶质细胞时空特性及Tau蛋白乙酰化NLRP3导致小胶质细胞活化的分子机制研究 项目负责人
2020-2023国家自然科学基金 696,000 RMB DNA损伤导致细胞周期重入在神经退变中的作用及分子机制研究 项目负责人
2019-2021华中科技大学自主创新研究基金100,000 RMB 肠道菌外膜囊泡对神经免疫的调节及其在神经退变中的作用机制研究 项目负责人
2018-2021 国家自然科学基金 700,000 RMB CIP2A对星形胶质细胞活化调控及其突触损伤机制研究 项目负责人
2017-2019 湖北省杰出青年基金200,000 RMB CIP2A对星形胶质细胞活化调控及其在阿尔茨海默病中的作用研究 项目负责人
2015-2018 国家自然科学基金 700,000 RMB CIP2A对蛋白磷酸酯酶2A的调节及其在阿尔茨海默病发病中的作用 项目负责人
2013-2016 国家自然科学基金 700,000 RMB Tau-PP2A-Src 复合体对NMDA 受体的异常调控在阿尔茨海默病发生中的作用 项目负责人
2013-2016国家自然科学基金中加老年痴呆症及相关病症合作研究项目3,000,000 RMB GSK-3 介导Aβ, tau 和胰岛素相关阿尔茨海默样突触和胆碱能损伤的机制研究 第二完成人
2012-2013 华中科技大学自主创新研究基金 50,000 RMB CIP2A 对PP2A 的调节及其在阿尔茨海默病发病中的作用 项目负责人
2010-2012 华中科技大学自主创新研究基金 70,000 RMB 锌离子对蛋白磷酸酯酶2A的调节和机制 项目负责人
2006-2008国家自然科学基金 240,000 RMB 蛋白磷酸脂酶2A的酪氨酸磷酸化修饰在AD发病中的作用 项目负责人
2005-2006 瑞典Stiftelsen Gamla tjänarinnor基金 30,000 Kr 项目负责人
2005-2006瑞典Gun Och Bertil Stohnes Stifielse基金 25,000 Kr 项目负责人
获奖情况:
1. 急性能量代谢障碍对微管相关蛋白Tau的影响 2005年获湖北省优秀硕士学位论文奖
2. 蛋白磷酸酯酶2A的酪氨酸磷酸化修饰在Alzheimer病发病中的作用 2008年获湖北省优秀博士学位论文奖
3. 蛋白激酶在阿尔茨海默病tau蛋白过度磷酸化中的作用及应用价值 2008年获中华医学科技奖二等奖
4. Tau蛋白过度磷酸化的机制及其对神经元生存命运的影响 2009年获教育部高等学校科学研究优秀成果奖自然科学奖一等奖
5. 2008年获华中科技大学青年教师讲课比赛二等奖
6. Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology,2010年获武汉市首届优秀学术论文奖
7. 2012,2014年获华中科技大学教学质量优秀奖二等奖