刘恭平，男，博士，教授，博士生导师。华中科技大学学术新人奖，教育部“新世纪优秀人才”计划获得者。1997年毕业于同济医科大学（现华中科技大学同济医学院），获医学学士学位；2000年获华中科技大学同济医学院医学硕士学位；2005年获华中科技大学同济医学院医学博士学位（劳动卫生与环境卫生学）；2005年9月进入华中科技大学同济医学院基础学部病理生理系做博士后，师从王建枝教授，从事ad发病机制的研究。2007年12月博士后出站，2008年1月留校担任教学和科研工作。

研究方向:

神经退行性疾病的发病机制、早期诊断及治疗策略

发表的有关论文（第一作者或通讯作者）：

1.jiang x, chai gs, wang zh, hu y, li xg, ma zw, wang q, wang jz, liu gp.camkii-dependent dendrite ramification and spine generation promote spatialtraining-induced memory improvement in a rat model of sporadic alzheimer'sdisease. neurobiol aging. 2014 oct 16. pii: s0197-4580(14)00675-7.

2.shang xl, wang qb, liu xp, yao xq, cao fy, wang q, zhang jy, wang jz, liu gp. fluorocitrate induced the alterations of memory-related proteins and tauhyperphosphorylation in sd rats. neurosci lett. 2014 oct 28;584c:230-235.

3.zhang y, ma rh, li xc, zhang jy, shi hr, wei w, luo dj, wang q, wang jz, liup. silencing [formula: see text] rescues tau pathologies and memory deficitsthrough rescuing pp2a and inhibiting gsk-3β signaling in human tau transgenicmice. front aging neurosci. 2014 jun 17;6:123.

4.luo dj, feng q, wang zh, sun ds, wang q, wang jz, liu gp. knockdown ofphosphotyrosyl phosphatase activator induces apoptosis via mitochondrial pathway and the attenuation by simultaneous tau hyperphosphorylation. j neurochem. 2014sep;130(6):816-25.

5.duan dx, chai gs, ni zf, hu y, luo y, cheng xs, chen nn, wang jz, liu gp.phosphorylation of tau by death-associated protein kinase 1 antagonizes thekinase-induced cell apoptosis. j alzheimers dis. 2013;37(4):795-808.

6.liu gp, wei w, zhou x, shi hr, liu xh, chai gs, yao xq, zhang jy, peng cx, hu j, li xc, wang q, wang jz. silencing pp2a inhibitor by lenti-shrna interferenceameliorates neuropathologies and memory deficits in tg2576 mice. mol ther. 2013dec;21(12):2247-57.

7.luo y, nie yj, shi hr, ni zf, wang q, wang jz, liu gp. ptpa activates protein phosphatase-2a through reducing its phosphorylation at tyrosine-307 withupregulation of protein tyrosine phosphatase 1b. biochim biophys acta. 2013may;1833(5):1235-43.

8.chai gs, jiang x, ni zf, ma zw, xie aj, cheng xs, wang q, wang jz, liu gp.betaine attenuates alzheimer-like pathological changes and memory deficitsinduced by homocysteine. j neurochem. 2013 feb;124(3):388-96.

9.yao xq, li xc, zhang xx, yin yy, liu b, luo dj, wang q, wang jz, liu gp.glycogen synthase kinase-3β regulates leucine-309 demethylation of proteinphosphatase-2a via ppmt1 and pme-1. febs lett. 2012 jul 30;586(16):2522-8.

10.liu xp, zheng hy, qu m, zhang y, cao fy, wang q, ke d, liu gp, wang jz.upregulation of astrocytes protein phosphatase-2a stimulates astrocytes migrationvia inhibiting p38 mapk in tg2576 mice. glia. 2012 sep;60(9):1279-88.

11.chen nn, luo dj, yao xq, yu c, wang y, wang q, wang jz, liu gp. pesticidesinduce spatial memory deficits with synaptic impairments and an imbalanced tauphosphorylation in rats. j alzheimers dis. 2012;30(3):585-94.

12.wei w, liu yh, zhang ce, wang q, wei z, mousseau dd, wang jz, tian q, liu gp.folate/vitamin-b12 prevents chronic hyperhomocysteinemia-induced tauhyperphosphorylation and memory deficits in aged rats. j alzheimers dis.2011;27(3):639-50.

13.yao xq, zhang xx, yin yy, liu b, luo dj, liu d, chen nn, ni zf, wang x, wang q, wang jz, liu gp. glycogen synthase kinase-3β regulates tyr307 phosphorylation of protein phosphatase-2a via protein tyrosine phosphatase 1b but not src.biochem j. 2011 jul 15;437(2):335-44.

14.liu gp, wei w, zhou x, zhang y, shi hh, yin j, yao xq, peng cx, hu j, wang q,li hl, wang jz. i(2)(pp2a) regulates p53 and akt correlatively and leads theneurons to abort apoptosis. neurobiol aging. 2012 feb;33(2):254-64.

15.liu gp, zhang y, yao xq, zhang ce, wang q, wang jz. activation of glycogen       synthase kinase-3 inhibits protein phosphatase-2a and the underlying mechanisms. neurobiol aging. neurobiol aging. 2008 sep;29(9):1348-58

16.yao z, guo z, yang c, tian q, gong cx, liu g, wang jz. phenylbutyric acid prevents rats from electroconvulsion-induced memory deficit with alterations of memory-related proteins and tau hyperphosphorylation. neuroscience. 2010 jun 30;168(2):405-15.

17.liu gp, shi n. the inhibitory effects of deltamethrin on dopamine biosynthesis inrat pc12 cells. toxicol lett. 2006;161(3):195-9.

18.liu gp, ma q,shi n. tyrosine hydroxylase as a target for deltamethrin in the nigrostriatal dopaminergic pathway. biomed environ sci. 2006;19:27-34.

主持基金：

2015年国际自然科学基金（面上）；

2013年国家自然科学基金（面上）；

2012年国际基金项目美国阿尔茨海默病协会的青年学者研究基金（第一）；

2009年国际基金项目美国阿尔茨海默病协会的研究者启动研究基金（iirg-09-13343；第三）；

2008年国家自然科学基金青年基金（30801212，第一）；

2007年中国博士后科学基金 （二等资助，第一）；

国家自然科学基金（30700277，第三）；

863计划（2006aa02z4a1，成员）

教育部创新团队（成员）

2010年华中科技大学学术新人奖

2012年教育部新世纪创新人才计划

所获奖励：

2008年中华医学科技奖贰等奖排名第四

2008年 湖北省自然科学奖一等奖排名第三

2006年湖北省优秀博士论文奖