雷家慧，病原生物学系教授，博士生导师，哈佛大学访问学者。现任基础医学院工会主席，病原生物学系支部副书记。主要研究方向为宿主和病原互作机制及虫源性分子调控疾病的免疫学机制。主持国家和省部课题8项，参与科技部国家重点研发项目、国家自然基金、973和863基金等10余项。以通讯或第一作者在Cell Commun. Signal.、Cell Death Dis、Inflammation等期刊发表论文 50 余篇。先后担任中国中医药出版社“十五五”规划教材《人体寄生虫学》主编和《免疫学基础和病原生物学》编委，人民卫生出版社公共卫生与预防医学“101 计划”《 病原生物与免疫学》、全国高等医学教育临床医学专业课程思政案例库《人体寄生虫学》、《临床寄生虫病学》和《人体寄生虫学》第八版电子教材编委。担任中华医学会热带病与寄生虫学分会青年委员、中华预防医学会医学寄生虫学分会青年委员、湖北省热带病与寄生虫学学会主任委员、湖北省预防医学会寄生虫学专业委员会常务委员、湖北省血吸虫病咨询委员会委员、武汉市预防医学会寄生虫学委员会副主任委员。兼任《中华地方病学杂志》、《Zoonoses》和《热带病与寄生虫学》杂志编委。

联系方式：leijiahui@hust.edu.cn

近年发表主要文章（#第一作者；*通讯作者）：

1.Guan F#, Luo Xi#, Huang Y, Chang J, Liu J, Zheng W, Zhang J, Gong Y, Gu H, WangY, Wu Y, Liu W, Lei J*, Liu C*. S100a4 mediated peritoneal B1 lymphocytes play a critical role in host protection against helminth infection. Cell Commun Signal. 2026 Jul 24;24(1):472. doi: 10.1186/s12964-026-03091-9.

2.Zhang JY, Zheng WW, Gong YY, Jia XF, Liu HL, Guan F*, Lei J*. A Hidden "Promoter": Schistosoma japonicum soluble egg antigen activates MAPK/PI3K-AKT pathways and inhibits autophagy to facilitate colorectal cancer. Infect Immun. 2026 Apr 15;94(4):e0069625. doi: 10.1128/iai.00696-25.

3.Gu H#, Xie M#, Zhao S, Luo X, Huang Y, Yang L, Guan F, Lei J*, Liu C*. DOCK8 gene mutation alters cell subsets, BCR signaling, and cell metabolism in B cells. Cell Death Dis 2024; 15(11):871. doi:10.1038/s41419-024-07180-w.

4.Zhu F#, Zheng W#, Gong Y, Zhang J, Yu Y, Zhang J, Liu M, Guan F*, Lei J*. Trichinella spiralis Infection Inhibits the Efficacy of RBD Protein of SARS-CoV-2 Vaccination via Regulating Humoral and Cellular Immunity. Vaccines (Basel). 2024 Jun 30;12(7):729. doi: 10.3390/vaccines12070729.

5.Zhu H#, Deng W, Guan F, Lei J*. Development of the WeChat Public Account I Love Parasitology and its Preliminary Application in the Teaching of Human Parasitology. J Med Educ Curric Dev. 2024 May 26:11:23821205241255224. doi: 10.1177/23821205241255224.

6.Lei J#, Feng Y, Zheng W, Khamis M, Zhang J, Hou X, Guan F*. Type I/II Immune Balance Contributes to the Protective Effect of AIF-1 on Hepatic Immunopathology Induced by Schistosoma japonicum in a Transgenic Mouse Model. Inflammation. 2024 Mar 30. doi: 10.1007/s10753-024-02010-9.

7.Guan F#, Luo X, Liu J, Huang Y, Liu Q, Chang J, Fang G, Kang D, Gu H, Luo L, Yang L, Lin Z, Gao X, Liu C, Lei J*. GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells. iScience. 2023 Jul 16;26(8):107341. doi: 10.1016/j.isci.2023.107341.

8.Hou X#, Zhu F, Zheng W, Jacques ML, Huang J, Guan F, Lei J*. Protective effect of Schistosoma japonicum eggs on TNBS-induced colitis is associated with regulating Treg/Th17 balance and reprogramming glycolipid metabolism in mice. Front Cell Infect Microbiol. 2022 Oct 11:12:1028899. doi: 10.3389/fcimb.2022.1028899.

9.Zhu F#, Liu W, Liu T, Shi L, Zheng W, Guan F, Lei J*. A New Role for Old Friends: Effects of Helminth Infections on Vaccine Efficacy. Pathogens. 2022 Oct 8;11(10):1163. doi: 10.3390/pathogens11101163.

10.Lei J#, Guan F, Zhu HG, Liu WQ*. Online education in human parasitology during the COVID-19 pandemic in Wuhan: Our experiences, challenges, and perspectives. Zoonoses, 2022, 2(1): 1.

11.Bai Y#, Guan F#, Zhu F, Jiang C, Zheng F, Liu W, Lei J*. IL-33/ST2 Axis Deficiency Exacerbates Hepatic Pathology by Regulating Treg and Th17 Cells in Murine Schistosomiasis Japonica. J Inflamm Res. 2021 Nov 15:14:5981-5998. doi: 10.2147/JIR.S336404.

12.Xin C#, Lei J#, Wang Q, Yin Y, Yang X, Moran Guerrero JA, Sabbisetti V, Sun X, Vaidya VS*, Bonventre JV*. Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease. iScience. 2021 Sep 29;24(10):103193. doi: 10.1016/j.isci.2021.103193.

13.Guan F#, Jiang W, Bai Y, Hou X, Jiang C, Zhang C, Jacques ML, Liu W, Lei J*. Purinergic P2X7 Receptor Mediates the Elimination of Trichinella spiralis by Activating NF-κB/NLRP3/IL-1β Pathway in Macrophages. Infect Immun. 2021 Apr 16;89(5):e00683-20. doi: 10.1128/IAI.00683-20.

14.Guan F#, Zhang C, Jiang C, Jacques ML, Bai Y, Lu S, Liu W, Lei J*. ApoE deficiency promotes hepatic pathology by aggravating Th17/Treg imbalance in murine schistosomiasis japonica. Parasite Immunol. 2020 Dec;42(12):e12785. doi: 10.1111/pim.12785.

15.Jacques M#, Mahamane Salissou M, Kaswiyi L, Guan F, Lei J*. Co-infection of malaria and HIV infection in severely undernourished children in the Democratic Republic of the Congo: a cross-sectional study. Parasitology. 2020 Feb;147(2):248-253. doi: 10.1017/S0031182019001513.