吕义晟，教授，博导

2007年在清华大学理学生物系获得博士学位，主要研究学习记忆的分子机理及老年痴呆症的发病机理。2008年赴美国Medical College of Georgia 进行博士后研究，在美期间主要从事精神分裂症的致病机理,以及神经肌肉接头发育以及相关疾病机理的研究，并在Neuron、Journal of Neuroscience、Journal of Clinical Investigation、Development、PNAS、Faseb J.等国际学术刊物上发表多篇学术论文。2015年5月回国工作，受聘为华中科技大学基础医学院生理学系教授。

联系方式：

基础医学院2号楼16楼1618

电话：027-83692622

Email：luys@hust.edu.cn

主要论文：

1.Ji H. So, Chao Huang, Minyan Ge, Guangyao Cai, Lanqiu Zhang, Yisheng Lu and Yangling Mu, Intense Exercise Promotes Adult Hippocampal Neurogenesis But Not Spatial Discrimination, Front Cell Neurosci. 2017, 11(13): eCollection

2.Haitao Wu, Arnab Barik, Yisheng Lu, Chengyong Shen, Andrew Bowman, Lei Li, Anupama Sathyamurthy, Thiri W. Lin, Wen Cheng Xiong, Lin Mei, Slit2 as a β-catenin/ctnnb1-dependent retrograde signal for presynaptic differentiation, elife 2015, 4: e07266

3.Yisheng Lu*, Xiangdong Sun*, Feng-Qing Hou, Lin-Lin Bi, Dong-Min Yin, Fang Liu, Yong-Jun Chen, Jonathan Bean, Hui-Feng Jiao, Xihui Liu, Bao-Ming Li, Wen-Cheng Xiong, Tian-Ming Gao and Lin Mei, Maintenance of GABAergic activity by neuregulin 1-ErbB4 in amygdala for fear memory, Neuron 2014, 84 (4): 835-846. (*: equal contribution)

4.Lin-Lin Bi, Xiang-Dong Sun, Jie Zhang, Yi-Sheng Lu, Yi-Hua Chen, Jue Wang, Fang Liu, Meng Zhang, Fei Geng, Ji-Hong Liu, Lin Mei and Tian-Ming Gao, Amygdala NRG1-ErbB4 is critical for the modulation of anxiety-like behaviors, Neuropsychopharmacology  2015, 40, 974–986

5.Arnab Barik*, Yisheng Lu*, Anupama Sathyamurthy, Andrew Bowman, Chengyong Shen, Wen-cheng Xiong, Lin Mei, LRP4 is critical for neuromuscular junction maintenance, Journal of Neuroscience. 2014, 34 (42):13892-13905. (*: equal contribution)

6.Chengyong Shen*, Yisheng Lu*, Bin Zhang*, Dwight Figueiredo‎, Haitao Wu, Barik Arnab, Wen-Cheng Xiong, Lin Mei, Antibodies against low-density lipoprotein receptor–related protein 4 induce myasthenia gravis, J. Clin. Invest. 2013, 123 (12), 5190-5202. (*: equal contribution)

7.Dong-Min Yin*, Yong-Jun Chen*, Yi-Sheng Lu, Jonathan C Bean, Anupama Sathyamurthy, Chengyong Shen, Xihui Liu, Clifford Smith, Wen-Cheng Xiong and Lin Mei, Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1, Neuron. 2013, 78 (4), 644-657. (*: equal contribution)

8.Haitao Wu, Yisheng Lu, Chengyong Shen, Neil Patel, Lin Gan, Wen C. Xiong, Lin Mei, Distinct Roles of Muscle and Motoneuron LRP4 in Neuromuscular Junction Formation, Neuron. 2012, 75 (1), 94-107.

9.Haitao Wu*, Yisheng Lu*, Arnab Barik, Anish Joseph, Mark Makoto Taketo, Wen-Cheng Xiong, Lin Mei. β-Catenin gain of function in muscles impairs neuromuscular junction formation. Development. 2012, 139, 2392-2404 (*: equal contribution).

10.Yong-Jun Chen, Meng Zhang, Dong-Min Yin, Lei Wen, Annie Ting, Pu Wang, Yi-Sheng Lu, Xin-Hong Zhu, Shu-Ji Li, Cui-Ying Wu, Xue-Ming Wang, Cary Lai, Wen-Cheng Xiong, Lin Meia, Tian-Ming Gao. ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. Proc. Natl. Acad. Sci. 2010, 107 (50), 21818-21823

11.Lei Wen*, Yi-Sheng Lu*, Xin-Hong Zhu*, Xiao-Ming Li, Ran-Sook Woo, Yong-Jun Chen, Dong-Min Yin, Cary Lai, Alvin V. Terry Jr., Almira Vazdarjanova, Wen-Cheng Xiong, Lin Mei. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc. Natl. Acad. Sci. 2010, 107 (3): 1211-1216 (*: equal contribution)

12.Yisheng Lu*, Yubing Lv*, Yihong Ye, Yalin Wang, Yu Hong, Mark E. Fortini, Yi Zhong, Zuoping Xie. A role for presenilin in post stress regulation: Effects of presenilin mutations on Ca2+ currents in Drosophila, FASEB J. 2007, 21: 2368-2378 (*: equal contribution)

13.Yubing Lu*, Yi-Sheng Lu*, Yichun Shuai, Chunhua Feng, Tim Tully, Zuoping Xie, Yizhong, Hai-Meng Zhou. The AKAP Yu is required for olfactory long-term memory formation in Drosophila, Proc. Natl. Acad. Sci. 2007, 104 (34): 13792-13797 (*: equal contribution)

14.Junjie Wang, Yisheng Lu, Zuoping Xie. Presenilin protein impacting synaptic sprouting on neuromuscular junction of Drosophila, Chin. J. Neuroanat. 2003, 19 (2): 161-164

15.Yufang Zheng, Bo Jiang, Yisheng Lu, Ying-Zi Li, Zuoping Xie. The effect of calcium ion on nicotinic acetylcholine receptor desensitization, Acta Biophysica Sinica 2000, 16 (1): 59-65

16.Manxi Liu, Yisheng Lu, Wang Xiaoqing. Peroxide enzyme and tyrosine kinase enzyme activity in chronic anoxia mouse are regulated by Sanqi and Danshen, J. Huazhong Univ. Sci. Technol. 1997, 25 (9): 95-97

主持科研项目

2010 NARSAD Young investigator award，Brain & Behavior Research Foundation  

7/15/2011-7/14/2013   $60, 000 Title：ErbB4 in amygdala is critical for cued fear conditioning

2017 国家自然科学基金面上项目：敲除多巴胺及其受体D2阳性神经元ErbB4引起精神分裂症表型的机制，起止年月：2017-01至2020-12，金额：60万元