荣岳光，华中科技大学基础医学院教授，博士生导师,同济医学院基础医学院病原生物系主任。2012年博士毕业于清华大学，生命科学学院。2013-2017于得州大学西南医学研究中心-自噬中心从事博士后研究。

联系邮箱:rongyueguang@hust.edu.cn

研究方向

主要使用高速活细胞成像技术结合各种细胞生物学、生物化学、结构生物学等先进的技术手段，以哺乳动物细胞、酵母和小鼠为模型研究：

1.细胞自噬、自噬体与溶酶体之间的相互作用、细胞器再生等细胞生物学现象。

2.细胞自噬与固有免疫之间的相互调控。

3.细胞自噬与病原体之间的互作。

4.细胞自噬与糖尿病和癌症等重大疾病之间的关系。

发表论文 

[1]Jian F*, Wang S*, Tian R, Wang Y, Li C, Li Y, Wang S, Fang C, Ma C^#, Rong Y^#. The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion, Cell Research, (2024)34(2):151-168. (IF 46.297)

[2]Zhao Y, Zhou C, Tian W, Chen Y, Zhao C, Li Y, Wang S, Rong Y^#. A specific module of ESCRT regulates STING activity termination by controlling STING degradation, Sci Bulletin,（2024）69(8):1000-1005. (IF 20.557)

[3]Wu Z, Que H, Li C, Yan L, Wang S, Rong Y^#. Rab32 family proteins regulate autophagosomal components recycling, Journal of Cell Biology, (2024)223(3). (IF 10.539)

[4]Wang Y, Que H, Li C, Wu Z, Jian F, Zhao Y, Tang H, Chen Y, Gao S, Wong CCL, Li Y, Zhao C, Rong Y^#. ULK phosphorylation of STX17 controls autophagosome maturation via FLNA, Journal of Cell Biology, (2023)222(8). (IF 10.539)

[5] Z. Wu*, C. Zhou*, H. Que, Y. Wang, Y. Rong^#, The fate of autophagosomal membrane components, Autophagy, (2022) 1-2. (IF 16.016)

[6] Y. Wang, H. Que, Y. Rong^#, Autophagosomal components recycling on autolysosomes,Trends in Cell Biology, (2022)In press.(IF 21.167)

[7] Chuchu Zhou* , Zhe Wu*, Wanqing Du*, Huilin Que , Yufen Wang , Qinqin Ouyang, Fenglei Jian , Weigang Yuan , Yuan Zhao , Rui Tian , Ying Li , Yang Chen , Shuaixin Gao, Catherine C. L. Wong   and Yueguang Rong^#, Recycling of autophagosomal components from autolysosomes by the recycler complex, Nature Cell Biology, 24(4) (2022) 497-512.(IF 28.213)

[8]Yueguang Rong*^#, Shen Zhang,* Nilay Nandi,* Zhe Wu,*Linsen Li, Yang Liu, Yuehan Wei, Yuan Zhao,Weigang Yuan,Chuchu Zhou, Guanghua Xiao, Beth Levine, Nan Yan, Shan Mou, Liufu Deng, Zaiming Tang, Xiaoxia Liu#, Helmut Kramer#, and Qing Zhong#, STING controls energy stress-induced autophagy and energy metabolism via STX17, Journal of Cell Biology,221(7) (2022). (IF 10.539)

[9]Y. Rong, M. Liu, L. Ma, W. Du, H. Zhang, Y. Tian, Z. Cao, Y. Li, H. Ren, C. Zhang, L. Li, S. Chen, J. Xi, L. Yu, Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation, Nature Cell Biology14(9) (2012) 924-34.(IF 28.213)

[10]Y. Rong*, C.K. McPhee*, S. Deng*, L. Huang, L. Chen, M. Liu, K. Tracy, E.H. Baehrecke, L. Yu, M.J. Lenardo, Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation, Proc Natl Acad Sci U S A108(19) (2011) 7826-31.(IF 12.779)

[11] J. Diao, R. Liu, Y. Rong, M. Zhao, J. Zhang, Y. Lai, Q. Zhou, L.M. Wilz, J. Li, S. Vivona, R.A. Pfuetzner, A.T. Brunger, Q. Zhong, ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes, Nature, 520(7548) (2015) 563-6. (IF 69.504)

[12] L. Yu, C.K. McPhee, L. Zheng, G.A. Mardones, Y. Rong, J. Peng, N. Mi, Y. Zhao, Z. Liu, F. Wan, D.W. Hailey, V. Oorschot, J. Klumperman, E.H. Baehrecke, M.J. Lenardo, Termination of autophagy and reformation of lysosomes regulated by mTOR, Nature, 465(7300) (2010) 942-6. (IF 69.504)

[13] M. Li, Y. Rong, Y.S. Chuang, D. Peng, S.D. Emr, Ubiquitin-dependent lysosomal membrane protein sorting and degradation, Mol Cell57(3) (2015) 467-78. (IF 19.328)

[14] W. Du, Q.P. Su, Y. Chen, Y. Zhu, D. Jiang, Y. Rong, S. Zhang, Y. Zhang, H. Ren, C. Zhang, X. Wang, N. Gao, Y. Wang, L. Sun, Y. Sun, L. Yu, Kinesin 1 Drives Autolysosome Tubulation, Dev Cell37(4) (2016) 326-36. (IF 13.417)

[15] X. Ma, S. Zhang, L. He, Y. Rong, L.W. Brier, Q. Sun, R. Liu, W. Fan, S. Chen, Z. Yue, J. Kim, K.L. Guan, D. Li, Q. Zhong, MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy, Autophagy,13(3) (2017) 592-607. (IF 16.016)

[16] J.J. Chen, J. Jing, H. Chang, Y.Rong, Y. Hai, J. Tang, J.L. Zhang, P. Xu, A sensitive and quantitative autolysosome probe for detecting autophagic activity in live and prestained fixed cells, Autophagy9(6) (2013) 894-904. (IF 16.016)

[17] X. Bai, X. Yang, X. Jia, Y. Rong, L. Chen, T. Zeng, X. Deng, W. Li, G. Wu, L. Wang, Y. Li, J. Zhang, Z. Xiong, L. Xiong, Y. Wang, L. Zhu, Y. Zhao, S. Jin, CAV1-CAVIN1-LC3B-mediated autophagy regulates high glucose-stimulated LDL transcytosis, Autophagy (2019). (IF 16.016)