唐科 教授 国家优青

ketang@hust.edu.cn

华中科技大学，同济基础医学院

专业方向 肿瘤免疫、肿瘤生物治疗、细胞代谢调控

课题组长期从事肿瘤免疫中关键细胞群体（T细胞和肿瘤干细胞）等方面的研究工作，重点研究肿瘤免疫T细胞长期的存活和肿瘤干细胞自我更新的代谢调控机制，并致力于新型肿瘤免疫生物治疗技术的开发与临床转化。

近五年来在细胞代谢和肿瘤免疫治疗领域以第一/通讯作者（含共同)在 Nature Immunology、Nature Cell Biology、Cellular & Molecular Immunology、Cancer Research和 Cancer immunology research等杂志发表多篇论文；作为主要发明人申报国内和国际PCT专利10项，授权5项。

学习经历

科研与学术工作经历

主要社会兼职

1．中国免疫学会肿瘤免疫与生物治疗分会委

2．Bioengineering客座主编

3．中国免疫学会会员；中国免疫学会肿瘤免疫与生物治疗分会委

主持科研项目

1. 国家自然科学基金委员会，优秀青年科学基金项目，8232204，代谢调控与肿瘤免疫治疗新策略，2024-01 至 2026-12，200万元，在研，主持。

2. 科学技术部高技术研究发展中心，国家重点研发计划（子课题），2022YFA1206000，工程化细胞微颗粒纳米药物可控制备及其肿瘤治疗新技术，2023-05 至 2028-04，225万元，在研，主持。

3. 国家自然科学基金委员会, 专项项目, 82150103, 肿瘤代谢微环境对中性粒细胞趋化、功能和代谢表型的影响以及相关机制探究, 2022-01-01 至 2024-12-31, 250万元, 在研, 主持。

4. 国家自然科学基金委员会, 面上项目, 82071864, 细胞来源的载药囊泡激发中性粒细胞抑制恶性胸腔积液相关机制研究, 2021-01-01 至 2024-12-31, 55万元, 在研, 主持。

5. 湖北省科技厅, 湖北省重点研发计划, 2020BCA068, 肺癌个体化生物免疫化疗与放疗联合创新技术与临床应用研究（子课题）, 2020-01 至 2022-12, 50万元, 结题, 主持。

6. 国家自然科学基金委员会, 重大研究计划, 91742112, 负载化疗药物的肿瘤微颗粒：重塑肺癌癌性胸水免疫微环境的机理探究, 2018-01-01 至 2020-12-31, 57万元, 结题, 参与。

7. 中国科学技术协会, 青年人才托举工程, YESS20160166, 探寻细胞来源囊泡在肿瘤生物治疗和肿瘤免疫治疗中的作用, 2017-01 至 2019-12, 45万元, 结题, 主持。

特邀会议报告

所获奖励

1. 2015年在第五届中国免疫学会获得青年免疫学者奖；

2. 2016年入选中国科学技术协会“青年人才托举工程”；

3. 2018年入选华中科技大学青年学术前沿团队（骨干成员）；

4. 2021年入选首批湖北省“青年拔尖人才”培养计划；

5. 2021年入选湖北省人才工作小组“科技副总”。

已发表论文（#并列第一作者，*通讯作者）

(1) Tang K, Zhang H, Deng J, Wang D, Liu S, Lu S, Cui Q, Chen C, Liu J, Yang Z, Li Y, Chen J, Lv J, Ma J, Huang B. Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles. Nat Immunol. 2023 Jan;24(1):162-173.

(2) Tang K, Ma J, Huang B. Macrophages' M1 or M2 by tumor microparticles: lysosome makes decision. Cell Mol Immunol. 2022 Oct;19(10):1196-1197.

(3) Wang D, Wu X, Jiang G, Yang J, Yu Z, Yang Y, Yang W, Niu X, Tang K^*, Gong J. Systematic analysis of the effects of genetic variants on chromatin accessibility to decipher functional variants in non-coding regions. Front Oncol. 2022 Oct 18;12:1035855.

(4) Tang K, Zhu L, Chen J, Wang D, Zeng L, Chen C, Zhou Y, Lv J, Liu Y, Zhang H, Ma J, Huang B. Hypoxia Promotes Breast Cancer Cell Growth by Activating a Glycogen Metabolic Program. Cancer Res. 2021 ;81(19):4949-63.

(5) Ma J^#, Tang K^#, Zhang H^#, Wei K, Huang B. Characterization and Functional Analysis of Tumor-Derived Microparticles. Curr Protoc. 2021;1(6):e144.

(6) Zhang H^#, Tang K^#, Ma J^#, Zhou L, Liu J, Zeng L, Zhu L, Xu P, Chen J, Wei K, Liang X, Lv J, Xie J, Liu Y, Wan Y, Huang B. Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T cell memory development. Nat Cell Biol. 2020 Jan;22(1):18-25.

(7) Chen J, Sun W, Zhang H, Ma J, Xu P, Yu Y, Fang H, Zhou L, Lv J, Xie J, Liu Y, Tang K*, Huang B*. Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1β. Cell Mol Immunol. 2020;17:1233-1244.

(8) Zhang H^#, Ma J^#, Tang K^#, Huang B. Beyond energy storage: roles of glycogen metabolism in health and disease. FEBS J. 2020 Nov 29.

(9) Ma J^#, Zhang H^#, Tang K^#, Huang B. Tumor-derived microparticles in tumor immunology and immunotherapy. Eur J Immunol. 2020 Nov;50(11):1653-1662.

(10) Xu P^#, Tang K^#, Ma J^#, Zhang H, Wang D, Zhu L, Chen J, Wei K, Liu J, Fang H, Tang L, Zhang Y, Xie J, Liu Y, Meng R, Liu L, Dong X, Yang K, Wu G, Ma F, Huang B. Chemotherapeutic tumor microparticles elicit a neutrophil response targeting malignant pleural effusions. Cancer Immunol Res. 2020 Sep;8(9):1193-1205.

(11) Tang K^#, Yu Y^#, Zhu L^#, Xu P, Chen J, Ma J, Zhang H, Fang H, Sun W, Zhou L, Wei K, Li F, Lv J, Xie J, Liu Y, Huang B. Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells. Oncogene. 2019 Oct;38(44):6970-6984.

(12) Liu J^#, Ma J^#, Tang K^#, Huang B. Therapeutic Use of Tumor Cell-Derived Extracellular Vesicles. Methods Mol Biol. 2017;1660:433-440.

(13) Tang K, Hu L, Ma J, Zhang H, Zhang Y, Li Y, Ma R, Luo S, Liu D, Long G, Han M, Liu S, Song A, Shen M, Hu G, Huang B. Brief Report: Human mesenchymal stem-like cells facilitate floating tumorigenic cell growth via glutamine-ammonium cycle. Stem Cells. 2015 Sep;33(9):2877-84.

(14) Zhang H^#, Tang K^#, Zhang Y^#, Ma R, Ma J, Li Y, Luo S, Liang X, Ji T, Gu Z, Lu J, He W, Cao X, Wan Y, Huang B. Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling. Cancer Immunol Res. 2015 Feb;3(2):196-205.

(15) Ma R^#, Zhang W^#, Tang K^#, Zhang H, Zhang Y, Li D, Li Y, Xu P, Luo S, Cai W, Ji T, Katirai F, Ye D, Huang B. Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma. Nat Commun. 2013;4:2508.

(16) Tang K, Zhang Y, Zhang H, Xu P, Liu J, Ma J, Lv M, Li D, Katirai F, Shen GX, Zhang G, Feng ZH, Ye D, Huang B. Delivery of chemotherapeutic drugs in tumour cell-derived microparticles. Nat Commun. 2012;3:1282.

(17) Tang K, Liu J, Yang Z, Zhang B, Zhang H, Huang C, Ma J, Shen GX, Ye D, Huang B. Microparticles mediate enzyme transfer from platelets to mast cells: A new pathway for lipoxin A4 biosynthesis. Biochem Bioph Res Co. 2010;400:432-436.

参与发表的论著

(1) Chen J, Zhou Y, Liu Z, Lu Y, Jiang Y, Cao K, Zhou N, Wang D, Zhang C, Zhou N, Shi K, Zhang L, Zhou L, Wang Z, Zhang H, Tang K, Ma J, Lv J, Huang B*. Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG. Science. 2024 Feb 16;383(6684):eadi3332.

(2) Ma J, Tang L, Tan Y, Xiao J, Wei K, Zhang X, Ma Y, Tong S, Chen J, Zhou N, Yang L, Lei Z, Li Y, Lv J, Liu J, Zhang H, Tang K,  Zhang Y, Huang B*. Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria. Nat Immunol. 2024 Jan 23.

(3) Zhou Y, Wang D, Zhou L, Zhou N, Wang Z, Chen J, Pang R, Fu H, Huang Q, Dong F, Cheng H, Zhang H, Tang K, Ma J, Lv J, Cheng T, Fiskesund R, Zhang X*, Huang B*. Cell softness renders cytotoxic T lymphocytes and T leukemic cells resistant to perforin-mediated killing. Nat Commun. 2024 Feb 15;15(1):1405.

(4) Zhang H, Yang Z, Yuan W, Liu J, Luo X, Zhang Q, Li Y, Chen J, Zhou Y, Lv J, Zhou N, Ma J, Tang K, Huang B*. Sustained AhR activity programs memory fate of  effector CD8⁺ T cells. Proc Natl Acad Sci USA. 2024 Mar 12;121(11):e2317658121.

(5) Zhou L, Wu D, Zhou Y, Wang D, Fu H, Huang Q, Qin G, Chen J, Lv J, Lai S, Zhang H, Tang K, Ma J, Fiskesund R, Zhang Y, Zhang X*, Huang B*. Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1. Nat Immunol. 2023 Dec;24(12):2042-2052.

(6) Wei K, Zhang H, Yang S, Cui Y, Zhang B, Liu J, Tang L, Tan Y, Liu S, Chen S, Yuan W, Luo X, Chen C, Li F, Liu J, Chen J, Xu P, Lv J, Tang K, Zhang Y, Ma J, Huang B*. Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1. Signal Transduct Target Ther.  2023 Jan 20;8(1):22.

(7)  Zhou N, Chen J, Ling Z, Zhang C, Zhou Y, Wang D, Zhou L, Wang Z, Sun N, Wang X, Zhang H, Tang K, Ma J, Lv J, Huang B*.AHR sulfenylation promotes glycogenolysis and rescues cancer chemoresistance.J Clin Invest. 2023 Dec 15;133(24):e170753.

(8)  Lv J, Zhou Y, Zhou N, Wang Z, Chen J, Chen H, Wang D, Zhou L, Wei K, Zhang H, Tang K, Ma J, Liu Y, Wan Y, Zhang Y, Zhang H, Huang B*. Epigenetic modification of CSDE1 locus dictates immune recognition of nascent tumorigenic cells. Sci Transl Med. 2023 Feb;15(681):eabq6024.

(9) Zhang H, Liu J, Yang Z, Zeng L, Wei K, Zhu L, Tang L, Wang D, Zhou Y, Lv J, Zhou N, Tang K, Ma J, Huang B. TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells. Mol Cell. 2022 Jun 17:S1097-2765(22)00538-X.

(10) Lv J, Liu Y, Mo S, Zhou Y, Chen F, Cheng F, Li C, Saimi D, Liu M, Zhang H, Tang K, Ma J, Wang Z, Zhu Q, Tong WM, Huang B. Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nat Cell Biol.2022 Mar;24:364-72.

(11) Liu Y*, Zhang T, Zhang H, Li J, Zhou N, Fiskesund R, Chen J, Lv J, Ma J, Zhang H, Tang K, Zhang X, Wang N, Huang B*. Cell softness prevents cytolytic T cell killing of tumor-repopulating cells. Cancer Res. 2021;81(2):476-88.

(12) Gao Y, Zhang H, Zhou N, Xu P, Wang J, Gao Y, Jin X, Liang X, Lv J, Zhang Y, Tang K, Ma J, Zhang H, Xie J, Yao F, Tong W, Liu Y*, Wang X*, Huang B*. Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma. Nat Biomed Eng. 2020 Jul;4(7):743-53.

(13) Ma J, Wei K, Liu J, Tang K, Zhang H, Zhu L, Chen J, Li F, Xu P, Chen J, Liu J, Fang H, Tang L, Wang D, Zeng L, Sun W, Xie J, Liu Y, Huang B. Glycogen metabolism regulates macrophage-mediated acute inflammatory responses. Nat Commun. 2020 Apr 14;11(1):1769.

(14)  Liang Q, Bie N, Yong T, Tang K, Shi X, Wei Z, Jia H, Zhang X, Zhao H, Huang W, Gan L*, Huang B*, Yang X*. The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency. Nat Biomed Eng. 2019 Sep;3(9):729-740.

(15) Zhang H, Yu Y, Zhou L, Ma J, Tang K, Xu P, Ji T, Liang X, Lv J, Dong W, Zhang T, Chen D, Xie Jing, Liu Y, Huang B. Circulating tumor microparticles promote lung metastasis by reprogramming inflammatory and mechanical niches via a macrophage-dependent pathway. Cancer Immunol Res. 2018;6:1046-56.

(16) Ma J, Wei K, Zhang H, Tang K, Li F, Zhang T, Liu J, Xu P, Yu Y, Sun W, Zhu L, Chen J, Zhou L, Liang X, Lv J, Fiskesund R, Liu Y, Huang B. Mechanisms underlying presentation of tumor microparticle antigens to CD8+ T cells by dendritic cells. Cancer Immunol Res. 2018;6:1057-68.

(17) Liu Y, Lv J, Liang X, Yin X, Zhang L, Chen D, Jin X, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Xie J, Wang N, Huang B. 3D Fibrin Stiffness mediates Dormancy of Tumor-repopulating cells via a Cdc42-driven Tet2 Epigenetic Program. Cancer Res. 2018;78:3926-37.

(18) Liu Y, Liang X, Dong W, Fang Y, Lv J, Zhang T, Fiskesund R, Xie J, Liu J, Yin X, Jin X, Chen D, Tang K, Ma J, Zhang H, Yu J, Yan J, Liang H, Mo S, Cheng F, Zhou Y, Zhang H, Wang J, Li J, Chen Y, Cui B, Hu ZW, Cao X, Qin FX, Huang B. Tumor repopulating cells induce PD-1 expression in CD8+ T cells by transferring kynurenine and AhR activation. Cancer Cell. 2018;33:480-494.

(19) Liu Y, Lv J, Liu J, Liang X, Jin X, Xie J, Zhang L, Chen D, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Jia Q, Zhu B, Kong Y, Guo J, Zhang H, Hu ZW, Cao X, Qin FX, Huang B. STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells. J Clin Invest. 2018;128:1057-73.

(20) Chen D, Xie J, Fiskesund R, Dong W, Liang X, Lv J, Jin X, Liu J, Mo S, Zhang T, Cheng F, Zhou Y, Zhang H, Tang K, Ma J, Liu Y, Huang B. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages towards M1 phenotype. Nat Commun. 2018;9:873.

(21)  Ma R, Ji T, Zhang H, Dong W, Chen X, Xu P, Chen D, Liang X, Yin X, Liu Y, Ma J, Tang K, Zhang Y, Peng Y, Lu J, Zhang Y, Qin X, Cao X, Wan Y, Huang B. A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells. Nat Cell Biol. 2018;20:21-27.

(22) Liu Y, Liang X, Yin X, Lv J, Tang K, Ma J, Ji T, Zhang H, Dong W, Jin J, Chen D, Li Y, Zhang S, Xie H, Zhao B, Zhao T, Lu J, Hu Z, Cao X, Qin X, Huang B. Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells. Nat Commun. 2017 May 10;8:15207.

(23) Jin X, Ma J, Liang X, Tang K, Liu Y, Yin X, Zhang Y, Zhang H, Xu P, Chen D, Zhang T, Lu J, Hu Z, Qin X, Zeng X, Li L, Huang B. Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder cancer through a lysosomal pathway. Biomaterials. 2017 Jan;113:93-104.

(24) Ma J, Zhang Y, Tang K, Zhang H, Yin X, Li Y, Xu P, Sun Y, Ma R, Ji T, Chen J, Zhang S, Zhang T, Luo S, Jin Y, Luo X, Li C, Gong H, Long Z, Lu J, Hu Z, Cao X, Wang N, Yang X, Huang B. Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles. Cell Res. 2016 Jun;26(6):713-27.

(25)  Ran L, Tan X, Li Y, Zhang H, Ma R, Ji T, Dong W, Tong T, Liu Y, Chen D, Yin X, Liang X, Tang K, Ma J, Zhang Y, Cao X, Hu Z, Qin X, Huang B. Delivery of oncolytic adenovirus into the nucleus of tumorigenic cells by tumor microparticles for virotherapy. Biomaterials. 2016 May;89:56-66.

(26) Li Y, Luo S, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Zhang Y, Liang X, Sun Y, Ji T, Wang N, Huang B. Upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate tumors. Cancer Res. 2015 Apr 1;75(7):1191-6.

(27) Ma R, Zhang W, Tang K, Zhang H, Zhang Y, Li D, Li Y, Xu P, Luo S, Cai W, Ji T, Katirai F, Ye D, Huang B. Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma. Nat Commun. 2013;4:2508.

(28)  Li D, Cai W, Gu R, Zhang Y, Zhang H, Tang K, Xu P, Katirai F, Shi W, Wang L, Huang T, Huang B. Th17 cell plays a role in the pathogenesis of Hashimoto's thyroiditis in patients. Clin Immunol. 2013 Dec;149(3):411-20.

(29)  Liu J, Tan Y, Zhang H, Zhang Y, Xu P, Chen J, Poh YC, Tang K, Wang N*, Huang B*. Soft fibrin gels promote selection and growth of tumorigenic cells. Nat Mater. 2012 Jul 1;11(8):734-41.

招生信息

课题组具备雄厚的师资力量，配套有各类国际、国内领先的仪器设备，科研经费充足，科研氛围浓厚。每年拟招收多名临床医学、基础医学、药学、生物学、生物信息学等相关专业的硕士/博士/博士后。欢迎各位热爱科研的优秀本科生与硕士生申请推荐免试/报考本实验室！