吴鹏飞，华中科技大学华中学者特聘教授、博士研究生导师，教育部“长江学者奖励计划”青年学者，湖北省医学青年拔尖人才（第一层次），湖北省健康科普专家。中国药理学会神经精神药理学会青年专业委员会副主任委员、武汉市药理学会理事。聚焦于“应激相关精神疾病的治疗学新机制与新策略” 这一医学前沿问题，开展转化医学&化学-神经生物学导向的精神疾病发生机制和干预靶点研究，为抑郁症、焦虑症、创伤后应激障碍、双相情感障碍等精神障碍提供治疗学新思路。主持国家自然科学基金4项，以通讯或第一作者（含共同）在Nature Metabolism、Redox Biology、Molecular Psychiatry、Brain, Behavior and Immunity、Biological Psychiatry、Aging Cell等国际知名期刊上发表论文34篇，他引1600余次。入选教育部基础医学“101计划”核心教材编委。获中国药理学会施维雅青年药理学家奖、高等学校科学研究优秀成果一等奖（6/7）、华夏医学科技进步奖（4/11）、湖北省自然科学优秀论文奖一等奖、华中科技大学教师教学竞赛一等奖、湖北省/武汉药理学会教学竞赛一等奖等奖励。两次在世界药理学大会 (WCP2018，日本京都；WCP2023，英国格拉斯哥) 上做报告。指导学生获第一届全国人工智能+大学生创新创业大赛一等奖（优秀指导老师）等。被评为华中科技大学十佳青年教工、华中科技大学优秀共产党员、华中科技大学优秀教师班主任等。

联系方式：wupengfeipharm@foxmail.com

主要研究项目：

1 No. 82373858 蛋氨酸氧化酶MICAL1介导的细胞骨架动力学异常在创伤后应激障碍中的作用及机制，国家自然科学基金面上项目，主持

2 No. 82073834 高尔基体酰基转移酶GODZ介导的GluN2B-NMDA受体脂分拣信号异常在抑郁症发生中的作用及其药物干预，国家自然科学基金面上项目，主持

3 No.81773712 转运蛋白SVCT2依赖的维生素C稳态调控机制异常在抑郁症发病中的作用及药物干预研究，国家自然科学基金面上项目，主持

4 No.81302754 蛋氨酸亚砜还原酶A负性调控ROS/MAPKs/NF-kB信号通路在小胶质细胞炎性活化中的作用及机制，国家自然科学基金青年科学基金项目，主持

5 2019 湖北省高校省级教学改革研究项目：德育目标导向的基础医学课程思政教育资源共享平台的建设和应用，主持

6 华中科技大学创新研究基金重点项目《基于蛋白质去棕榈酰化机制的AMPA受体增强剂开发及其抗抑郁效应研究》，主持

7 华中科技大学创新研究基金（转化医学专项）《氧化应激生物标记物蛋白质蛋氨酸亚砜的快速检测试剂盒》，主持

代表性学术论文：

Cun-Dong Huang, Yu Shi, Fang Wang*(通讯作者), Peng-Fei Wu* (通讯作者), Jian-Guo Chen*(通讯作者). Methionine oxidation of actin cytoskeleton attenuates traumatic memory retention via reactivating dendritic spine morphogenesis. Redox Biol. 2024:77:103391.

Xia-Ping Yao, Jian Ye, Ting Feng, Feng-Chao Jiang, Ping Zhou, Fang Wang*(通讯作者), Jian-Guo Chen*(通讯作者), Peng-Fei Wu*(通讯作者). Adaptor protein MyD88 confers the susceptibility to stress via amplifying immune danger signals. Brain Behav Immun. 2023; 108:204-220.  

Pei Wang, Peng-Fei Wu^# (共同第一作者), Hua-Jie Wang, Fang Liao, Fang Wang* (通讯作者), Jian-Guo Chen* (通讯作者). Gut microbiome-derived ammonia modulates stress vulnerability in the host. Nature Metabolism 2023; 5(11):1986-2001. (相关专题评述：Keep calm with ammonia-producing microbiota. Nat Rev Microbiol. 2024;22(1):2. )

Jia-Jing Lu, Peng-Fei Wu^# (共同第一作者), Jin-Gang He, Yu-Ke Li, Li-Hong Long, Xia-Ping Yao, Jia-Hao Yang, Hong-Sheng Chen, Xiangnan Zhang, Zhuang-Li Hu, Zhong Chen, Fang Wang* (通讯作者) and Jian-Guo Chen*(通讯作者). BNIP3L/NIX-mediated mitophagy alleviates passive stress-coping behaviors induced by tumor necrosis factor-α. Molecular Psychiatry 2023 Mar 13. doi: 10.1038/s41380-023-02008-z.

Qian-Qian Han, Peng-Fei Wu^#* (共同第一/通讯作者), Yi-Heng Li, Yu Cao, Jian-Guo Chen*(通讯作者), Fang Wang*(通讯作者). SVCT2-mediated ascorbic acid uptake buffers stress responses via DNA hydroxymethylation reprogramming of S100 calcium-binding protein A4 gene. Redox Biology 2022; 58:102543.  

Peng-Fei Wu^#, Xin-Lei Guan^#, Fang Wang, Jian-Guo Chen*. N-acetylcysteine facilitates extinction of cued fear memory in rats via reestablishing basolateral amygdala glutathione homeostasis. Acta Pharmacologica Sinica 2022; 43(2):260-272.

Pei Wang, Fang Wang, Lan Ni, Peng-Fei Wu*(通讯作者), Jian-Guo Chen*(通讯作者). Targeting redox-altered plasticity to reactivate synaptic function: A novel therapeutic strategy for cognitive disorder, Acta Pharm Sin B 2021, 11(3):599-608.

Peng-Fei Wu^#, Qian-Qian Han^#, Fu-Feng Chen, Tian-Tian Shen, Yi-Heng Li, Yu Cao, Jian-Guo Chen, Fang Wang*. Erasing m6A-dependent transcription signature of stress-sensitive genes triggers antidepressant actions. Neurobiology of Stress 2021, 15:100390.

Xu JF, Lu JJ, Cao Y, Wang W, Li HH, Chen JG, Wang F(通讯作者), Wu PF (通讯作者). Sulforaphane alleviates ethanol-mediated central inhibition and reverses chronic stress-induced aggravation of acute alcoholism via targeting Nrf2-regulated catalase expression. Neuropharmacology. 2020; 176:108235.

Luo H, Wu PF^# (共同第一作者), Cao Y, Jin M, Shen TT, Wang J, Huang JG, Han QQ, He JG, Deng SL, Ni L, Hu ZL, Long LH, Wang F, Chen JG. Angiotensin-Converting Enzyme Inhibitor Rapidly Ameliorates Depressive-Type Behaviors via Bradykinin-Dependent Activation of Mammalian Target of Rapamycin Complex 1. Biological Psychiatry. 2020; 88(5):415-425. (相关专题评述：Bringing in the ACE(i): Angiotensin-Converting Enzyme Inhibitors as Antidepressants. Biol Psychiatry. 2020；Angiotensin-converting enzyme inhibitors produce rapid antidepressant effects in a bradykinin-dependent manner. Folia Pharmacologica Japonica 2020 )

Shen ZC, Wu PF^# (共同第一作者),Wang F, Deng Q, Nie TL, Zhang SQ, Zheng HL, Liu WH, Lu JJ, Gao SQ, Yao XP, Long LH, Hu ZL, Chen JG. Gephyrin Palmitoylation in Basolateral Amygdala Mediates the Anxiolytic Action of Benzodiazepine. Biological Psychiatry 2019; 85(3):202-213.

Xia ZX, Shen ZC, Zhang SQ, Wang J, Nie TL, Deng Q, Chen JG, Wang F*(通讯作者), Wu PF*(通讯作者). De-palmitoylation by N-(tert-Butyl) hydroxylamine inhibits AMPAR-mediated synaptic transmission via affecting receptor distribution in postsynaptic densities. CNS Neurosci Ther 2019; 25(2):187-199.

Luo H, Wu PF^# (共同第一作者), Han QQ, Cao Y, Deng SL, Wang J, Deng Q, Wang F, Chen JG. Reactive Sulfur Species Emerge as Gliotransmitters to Support Memory via Sulfuration-Dependent Gating of NR2A-Containing N-Methyl-d-Aspartate Subtype Glutamate Receptor Function. Antioxid Redox Signal 2019; 30(16):1880-1899.

Li YL, Wu PF^# (共同第一作者), Chen JG, Wang S, Han QQ, Li D, Wang W, Guan XL, Li D, Long LH, Huang JG, Wang F. Activity-Dependent Sulfhydration Signal Controls N-Methyl-D-Aspartate Subtype Glutamate Receptor-Dependent Synaptic Plasticity via Increasing d-Serine Availability. Antioxid Redox Signal 2017; 27(7):398-414.（封面文章）

Guan XL, Wu PF^# (共同第一作者), Wang S, Zhang JJ, Shen ZC, Luo H, Chen H, Long LH, Chen JG, Wang F. Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A-dependent catalytic mechanism. Aging Cell. 2017; 16(2): 226-236.

Fan H, Wu PF^# (共同第一作者), Zhang L, Hu ZL, Wang W, Guan XL, Luo H, Ni M, Yang JW, Li MX, Chen JG*, Wang F*. Methionine sulfoxide reductase A negatively controls microglia-mediated neuroinflammation via inhibiting ROS/MAPKs/NF-κB signaling pathways through a catalytic antioxidant function. Antioxid Redox Signal. 2015; 22(10):832-47.

Li YL, Zhou J, Zhang H, Luo Y, Long LH, Hu ZL, Chen JG, Wang F, Wu PF (通讯作者). Hydrogen Sulfide Promotes Surface Insertion of Hippocampal AMPA Receptor GluR1 Subunit via Phosphorylating at Serine-831/Serine-845 Sites Through a Sulfhydration-Dependent Mechanism. CNS Neurosci Ther. 2016, 22(9):789-98.

Wang X, Cao H, Guan XL, Long LH, Hu ZL, Ni L, Wang F, Chen JG, Wu PF (通讯作者). Sulfite triggers sustained calcium overload in cultured cortical neurons via a redox-dependent mechanism. Toxicol Lett.2016, 258:237-48.

Han J, Zhang H, Wang S, Zhou J, Luo Y, Long LH, Hu ZL, Wang F, Chen JG, Wu PF (通讯作者). Potentiation of Surface Stability of AMPA Receptors by Sulfhydryl Compounds: A Redox-Independent Effect by Disrupting Palmitoylation. Neurochem Res. 2016, 41(11):2890-2903.

Ma J, Long LH, Hu ZL, Zhang H, Han J, Ni L, Wang F, Chen JG, Wu PF(通讯作者). Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons. Brain Res. 2015; 1615:71-9.

Wu PF, Xie N, Zhang JJ, Guan XL, Zhou J, Long LH, Li YL, Xiong QJ, Zeng JH, Wang F, Chen JG*. Resveratrol preconditioning increases methionine sulfoxide reductases A expression and enhances resistance of human neuroblastoma cells to neurotoxins. J Nutr Biochem. 2013; 24(6):1070-7.

Wu PF, Zhang Z, Guan XL, Li YL, Zeng JH, Zhang JJ, Long LH, Hu ZL, Wang F, Chen JG. A specific and rapid colorimetric method to monitor the activity of methionine sulfoxide reductase A. Enzyme Microb Technol. 2013; 53(6-7):391-7.

Wu PF, Long LH, Zeng JH, Guan XL, Zhou J, Jin Y, Ni L, Wang F, Chen JG, Xie N. Protection of L-methionine against H₂O₂-induced oxidative damage in mitochondria. Food Chem Toxicol. 2012, 50(8):2729-35.

Lu HF, Wu PF^# (共同第一作者), Yang YJ, Xiao W, Fan J, Liu J, Li YL, Luo Y, Hu ZL, Jin Y, Wang F*, Chen JG*. Interactions between N-ethylmaleimide- sensitive factor and GluR2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine. J Neurosci. 2014; 34(10):3493-508.

Yang YJ, Wu PF^# (共同第一作者), Long LH, Yu DF, Wu WN, Hu ZL, Fu H, Xie N, Jin Y, Ni L, Wang JZ, Wang F*, Chen JG*. Reversal of aging- associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function. Aging Cell. 2010; 9(5):709-21.

发明专利：

1 红藻氨酸和/或红藻氨酸盐在制备抗焦虑药物中的应用，申请号：2024114846279，排名第二

2  2-溴棕榈酸滴鼻剂在制备抗抑郁药物中的应用，申请号：2024114847036，排名第二

3  一种用于防治创伤后应激综合征的药物和功能性食品；授权专利号：ZL 2017 1 1235555.4，排名第二

4  一种快速消除口臭的生物技术口气清新剂及其医药用途；授权专利号：ZL 2015 1 0870376.2，排名第二；

5一种蛋氨酸亚砜还原酶活性的检测方法及药物筛选试剂盒；授权专利号：ZL 2009 1 0273177.8，排名第二；

6 重组Trx-TAT-hMsrA融合蛋白及其在神经细胞保护方面的应用；授权专利号：ZL 2010 1 0197729.4，排名第三（“独占许可”形式转让）；

7 含巯基他克林衍生物及其制备方法和应用；授权专利号：ZL 2011 1 0216334. 9，排名第六；

8 氨基噻唑衍生物及制备方法和医药用途；授权专利号：ZL 2011 1 0216344.2，排名第七