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刘丹 湖北省武汉市航空路13号同济医学院医学遗传系 邮件：liudan_echo@mail.hust.edu.cn 手机：15926309921 QQ：496013260 |
个人简介
刘丹，讲师，硕士生导师，湖北省优秀博士论文获得者。研究方向：表观遗传学在神经精神疾病中的作用。承担国家自然科学基金青年项目一项。目前发表SCI论文16篇，其中包括Neuron, J Neurosci, Cell Death & Differ, Mol Neurobiol等国际知名杂志。
教育经历
2006/9-2011/6，华中科技大学，基础医学院病理生理学，博士
2002/9-2006/6，华中科技大学，药学，本科
留学经历
2012/10-2013/10，美国路易斯安娜州立大学，健康医学中心神经科学中心，博士后
工作经历
2012/3-至今，华中科技大学，基础医学院，讲师
承担教学工作情况
承担五年制临床医学、法医和医学影像学及四年制检验班等本科生的医学遗学的理论及实验课的教学；承担研究生的医学遗传学、高级医学遗传学及医学遗传学进展等课程的教学。
研究方向
主要从事阿尔茨海默病（Alzheimer’s disease, AD）发病的分子机制及防治措施的研究。该病是最常见的一类老年痴呆症，以进行性认识功能障碍为特征，严重影响老年人群的生活质量，同时对整个社会也带来极大的负担。然而，目前对于该病的发病机制、预防及治疗措施尚不清楚。微小RNA是一类高度保守的非编码RNA，其主要在转录/转录后水平对基因的表达进行调控。近年来的研究表明microRNA的失调对AD的发病进程起重要作用，所以本课题组的主要研究方向为microRNA在AD发病中的作用与机制研究。
主持科研项目
华中科技大学自主创新基金，编号2012QN134，糖原合酶激酶3 在阿尔茨海默病突触病变中的作用和机制，2012.05-2013.12，金额5万，负责人。（已结题）
国家自然科学基金，编号31201011，糖原合酶激酶3 对树突棘可塑性的调控作用和机制及其应用，2013.01-2015.12，金额23万，负责人。（已结题）
华中科技大学自主创新基金，编号2015QN143，褪黑素受体2 对突触可塑性的调控作用及机制，2015.01-2016.12，金额5万，负责人。（在研）
发表论文
Liu, D; Wei, N; Man, H-Y; Lu, Y(*); Zhu, L-Q(*); Wang, J-Z(*),The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling., Cell Death and Differentiation.
Wei, Na; Zhu, Ling-Qiang; Liu, Dan(*),ATF4: a Novel Potential Therapeutic Target for Alzheimer's Disease., Molecular Neurobiology.
Wang, Xiang; Wang, Liang-Ping; Tang, Hui; Shan, Wan-Ying; Wang, Xiong; Liu, Dan(*); Wu, Yuan-Yuan; Tian, Qing; Wang, Jian-Zhi(*); Zhu, Ling-Qiang(*),Acetyl-L-carnitine rescues scopolamine-induced memory deficits by restoring insulin-like growth factor II via decreasing p53 oxidation, Neuropharmacology, 76卷, pp 80-87, 2014/1.
Tang, Hui(#); Shen, Na(#); Jin, Huijuan(#); Liu, Dan(*); Miao, Xiaoping(*); Zhu, Ling-Qiang(*),GSK-3 beta Polymorphism Discriminates Bipolar Disorder and Schizophrenia: A Systematic Meta-Analysis, Molecular Neurobiology, 48(3), pp 404-411, 2013/12.
Tan, Lu; Wang, Xiong; Ni, Zhong-Fei; Zhu, Xiuming; Wu, Wei; Zhu, Ling-Qiang; Liu, Dan(*),A Systematic Analysis of Genomic Changes in Tg2576 Mice, Molecular Neurobiology, 47(3), pp 883-891, 2013/6.
Wang Xiong(#); Wang Zhi-Hao(#); Wu Yuan-Yuan; Tang Hui; Tan Lu; Wang Xiang; Gao Xinya; Xiong Yansi; Liu Dan(*); Wang Jian-Zhi; Zhu Ling-Qiang(*),Melatonin attenuates scopolamine-induced memory/synaptic disorder by rescuing EPACs/miR-124/Egr1 pathway., Molecular Neurobiology, 47(1), pp 373-381, 2013/2/20.
Yang, Ying(#); Shu, Xiaogang(#); Liu, Dan(#); Shang, You; Wu, Yan; Pei, Lei; Xu, Xin; Tian, Qing; Zhang, Jian; Qian, Kun; Wang, Ya-Xian; Petralia, Ronald S.; Tu, Weihong; Zhu, Ling-Qiang(*); Wang, Jian-Zhi(*); Lu, Youming(*),EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation, Neuron, 73(4), pp 774-788, 2012/2/23.
Liu, Dan; Zheng, Hong-Yun; Luo, Zheng-Zhao; Wang, Qun; Zhu, Ling-Qiang,Culture of newborn monkey liver epithelial progenitor cells in chemical defined serum-free medium, In Vitro Cellular & Developmental Biology-Animal, 46(8), pp 702-707, 2010/9.
Zhu, Ling-Qiang(#); Liu, Dan(#); Hu, Juan; Cheng, Jin; Wang, Shao-Hui; Wang, Qun; Wang, Fang; Chen, Jian-Guo; Wang, Jian-Zhi(*),GSK-3 beta Inhibits Presynaptic Vesicle Exocytosis by Phosphorylating P/Q-Type Calcium Channel and Interrupting SNARE Complex Formation, Journal of Neuroscience, 30(10), pp 3624-3633, 2010/3/10.
Zhu, Ling-Qiang(#); Zheng, Hong-Yun(#); Peng, Cai-Xia; Liu, Dan; Li, Hong-Lian; Wang, Qun; Wang, Jian-Zhi,Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2, Journal of Neuroscience, 30(10), pp 3839-3848, 2010/3/10.
Zhu, Ling-Qiang; Wang, Shao-Hui; Liu, Dan; Yin, Yang-Yang; Tian, Qing; Wang, Xiao-Chuan; Wang, Qun; Chen, Jian-Guo; Wang, Jian-Zhi,Activation of glycogen synthase kinase-3 inhibits LongTerm Potentiation with synapse-associated impairments, Journal of Neuroscience, 27(45), pp 12211-12220, 2007/11/7.
Zhou, Peng, Chen, Zhuo, Zhao, Ning, Liu, Dan, Guo, Zi-Yuan, Tan, Lu, Hu, Juan, Wang, Qun, Wang, Jian-Zhi, *Zhu, Ling-Qiang, 2011,Acetyl-L-Carnitine Attenuates Homocysteine-Induced Alzheimer-Like Histopathological and Behavioral Abnormalities, 14(6), pp 669-679(2011, SCI, IF=4.2250(2010))
Peng, Cai-Xia(#); Hu, Juan(#); Liu, Dan; Hong, Xiao-Ping; Wu, Yuan-Yuan; Zhu, Ling-Qiang(*); Wang, Jian-Zhi(*),Disease-modified glycogen synthase kinase-3 beta intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model, Neurobiology of Aging, 34(6), pp 1555-1563, 2013/6.
Wu, Yuan-Yuan; Wang, Xiong; Tan, Lu; Liu, Dan; Liu, Xing-Hua; Wang, Qun; Wang, Jian-Zhi(*); Zhu, Ling-Qiang(*),Lithium Attenuates Scopolamine-Induced Memory Deficits with Inhibition of GSK-3 beta and Preservation of Postsynaptic Components, Journal of Alzheimer's Disease, 37(3), pp 515-527, 2013.
Wang, Shao-Hui; Liao, Xiao-Mei; Liu, Dan; Hu, Juan; Yin, Yang-Yang; Wang, Jian-Zhi(*); Zhu, Ling-Qiang(*),NGF promotes long-term memory formation by activating poly(ADP-ribose) polymerase-1, Neuropharmacology, 63(6), pp 1085-1092, 2012/11.
Juan Hu; Xiang Wang; Dan Liu; Qun Wang; Ling-Qiang Zhu(*),Olfactory deficits induce neurofilament hyperphosphorylation, Neuroscience Letters, 506(2), pp 180-183, 2012 1月.
Kai Liao; Dan Liu; Ling-Qiang Zhu(*),Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex., Neuroscience Letters, 507(1), pp 22-26, 2012 1月.
Hu, Juan; Huang, He-Zhou; Wang, Xiang; Xie, Ao-Ji; Wang, Xiong; Liu, Dan; *Wang, Jian-Zhi; *Zhu, Ling-Qiang,Activation of Glycogen Synthase Kinase-3 Mediates the Olfactory Deficit-Induced Hippocampal Impairments., Molecular Neurobiology, 52(3), pp 1601-1617, 2015/12.
Xiong, Yan-Si; Liu, Fang-Fang; Liu, Dan; Huang, He-Zhou; Wei, Na; Tan, Lu; Chen, Jian-Guo; Man, Heng-Ye; Gong, Cheng-Xin; Lu, Youming; Wang, Jian-Zhi; Zhu, Ling-Qiang,Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway., Aging Cell, 14(5), pp 867-877, 2015/10.
Li, Ke; Liu, Fang-Fang; He, Chun-Xue; Huang, He-Zhou; Xie, Ao-Ji; Hu, Fan; Liu, Dan; Wang, Jian-Zhi; Zhu, Ling-Qiang,Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5., Molecular Neurobiology, 2014/12/3.
Chen, Yaomin(#); Wang, Bin(#); Liu, Dan; Li, Jing Jing; Xue, Yueqiang; Sakata, Kazuko; Zhu, Ling-qiang; Heldt, Scott A.; Xu, Huaxi; Liao, Francesca-Fang(*),Hsp90 Chaperone Inhibitor 17-AAG Attenuates A beta-Induced Synaptic Toxicity and Memory Impairment, Journal of Neuroscience, 34(7), pp 2464-2470, 2014/2/12.
专利
朱铃强；高鑫雅；刘丹；王志昊；马禹佳；毛璐,番茄红素在制备防治老年痴呆药物中的应用
朱铃强；王雄；刘丹；谭璐；黄和周,一种用于预防和治疗老年性痴呆的药物及制剂, 2014/7/30, 湖北, CN201410151210.0.
朱铃强；谭璐；周鹏；王雄；刘丹,一种防治老年痴呆的药物, 2014/5/28, 湖北, CN201410082815.9.
奖励与荣誉
2010年9月获教育部首届“博士研究生学术新人奖”；
2012年12月获湖北省优秀博士论文奖；
2015年7月获华中科技大学“学术新人奖”
