刘超红，华中科技大学附属同济医院过敏与临床免疫研究所副所长，同济儿童医院儿研所副所长，基础医学院微生物系教授，科研副主任，2017年国家自然科学基金优秀青年基金获得者。2003年于武汉大学获理学学士学位，2006年于中科院武汉病毒所获硕士学位。2013于美国马里兰大学帕克分校获博士学位。2013以研究助理加入到圣裘德儿童研究医院迟洪波实验室。现在主要研究领域是呼吸和血液系统免疫相关疾病。研究方向包括儿童免疫缺陷性肺炎和自身免疫疾病的免疫异常机制，呼吸道病毒感染所导致的宿主免疫系统紊乱以及哮喘产生的机制。以通讯作者发表43篇SCI论文。其工作在Immunity、 Blood、Journal of Allergy and Clinical Immunology、Nature Communications、Science Advances、PLos Biology、 Leukemia、 Journal of Experimental Medicine、 Cell report 和Journal of Immunology等杂志发表。任中国生理学会血液分会委员，亚太医学生物免疫学会基础免疫学分会副秘书长，湖北省生物免疫学会转化医学专委会副主委，Journal of Clinical and Translational Hepatology 杂志Associate editor和Journal of Leukocyte Biology编辑。担任Signal Transduction and Targeted Therapy、Cellular and Molecular Immunology和eLife等杂志审稿人。以负责人身份承担了国家重点研发计划和国际合作项目等7项国家级项目,参与3项重点研发计划。以第一完成人获湖北省自然科学奖二等奖，培养了数名博士后和研究生。

联系方式：chaohongliu80@126.com

发表文章

(^#Co-first author ,*Co-corresponding author)

Jiang P, Jing Y, Zhao S, Lan C, Yang L, Dai X, Luo L, Cai S, Zhu Y, Miller H, Lai J, Zhang X, Zhao X, Wu Y, Yang J, Zhang W, Guan F, Zhong B, Umehara H, Lei J, Dong L*,Liu C*.Expression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease. Nat Commun. 2024 Mar 23;15(1):2627. doi: 10.1038/s41467-024-45977-7. PMID: 38521787; PMCID: PMC10960850.IF=16.6

Yu H, Yang L, Han Z, Zhou X, Zhang Z, Sun T, Zheng F, Yang J, Guan F, Xie J,Liu C. SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species. J Med Virol. 2023 Dec;95(12):e29270. doi: 10.1002/jmv.29270. PMID: 38047459.IF=12.7

Yang Y, Miller H, Byazrova MG, Cndotti F, Benlagha K, Camara NOS, Shi J, Forsman H, Lee P, Yang L, Filatov A*, Zhai Z*,Liu C*. The characterization of CD8+ T-cell responses in COVID-19. Emerg Microbes Infect. 2024 Dec;13(1):2287118. doi: 10.1080/22221751.2023.2287118. Epub 2024 Jan 11. PMID: 37990907; PMCID: PMC10786432.IF=13.2

Gu H, Fu Y, Yu B, Luo L, Kang D, Xie M, Jing Y, Chen Q, Zhang X, Lai J, Guan F, Forsman H, Shi J, Yang L, Lei J, Du X, Zhang X*,Liu C*. Ultra-high static magnetic fields cause immunosuppression through disrupting B-cell peripheral differentiation and negatively regulating BCR signaling. MedComm (2020). 2023 Oct 1;4(5):e379. doi: 10.1002/mco2.379. PMID: 37789963; PMCID: PMC10542999.IF=10.1

Wang X, Guan F, Miller H, Byazrova MG, Cndotti F, Benlagha K, Camara NOS, Lei J, Filatov A*,Liu C*. The role of dendritic cells in COVID-19 infection. Emerg Microbes Infect. 2023 Dec;12(1):2195019. doi: 10.1080/22221751.2023.2195019. PMID: 36946172; PMCID: PMC10171120.IF=13.2

Yu H, Guan F, Miller H, Lei J,Liu C. The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development. Emerg Microbes Infect. 2022 Dec 30:2164219.IF=13.2 

Du Z, Huang L, Dai X, Yang D, Niu L, Miller H, Ruan C, Li H, Hu L, Zhou L, Jian D, Sun J, Shi X, Huang P, Chen Y, Zhao X*,Liu C*. Progranulin regulates the development and function of NKT2 cells through EZH2 and PLZF. Cell Death Differ. 2022 Oct;29(10):1901-1912.IF=12.074

Zhu Y^#, Gu H^#, Yang L, Li N, Chen Q, Kang D, Lin S, Jing Y, Jiang P, Chen Q, Luo L, Liu J, Chang J, Li Z, Wang Y, Dai X, Miller H, Westerberg LS, Park CS, Kubo M, Gong Q, Dong L*,Liu C*. Involvement of MST1/mTORC1/STAT1 activity in the regulation of B-cell receptor signalling by chemokine receptor 2.Clin Transl Med. 2022 Jul;12(7):e887.IF=10.6

Dai Z^#, Mu W^#, Zhao Y, Cheng J, Lin H, Ouyang K, Jia X, Liu J, Wei Q, Wang M,Liu C, Tan T, Zhou J. T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape. Signal Transduct Target Ther. 2022 Mar 25;7(1):85.IF=38.120

He M, Saeed MB, Record J, Keszei M, Gonçalves Pinho L, Vasconcelos-Fontes L, D'Aulerio R, Vieira R, Oliveira MMS, Geyer C, Bohaumilitzky L, Thiemann M, Deordieva E, Buedts L, Matias Lopes JP, Pershin D, Hammarström L, Xia Y, Zhao X, Cunningham-Rundles C, Thrasher AJ, Burns SO, Cotta-de-Almeida V,Liu C, Shcherbina A, Vandenberghe P, Westerberg LS. Overactive WASp in X-linked neutropenia leads to aberrant B-cell division and accelerated plasma cell generation. J Allergy Clin Immunol. 2022 Mar;149(3):1069-1084.IF=14.291、

Jing Y^#, Luo L^#, Chen Y, Westerberg LS, Zhou P, Xu Z, Herrada AA, Park CS, Kubo M, Mei H, Hu Y, Lee PP, Zheng B, Sui Z, Xiao W, Gong Q, Lu Z*,Liu C*.SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism. Signal Transduct Target Ther. 2021 Sep 22;6(1):345.IF=38.120

Yang L, Li N, Yang D, Chen A, Tang J, Jing Y, Kang D, Jiang P, Dai X, Luo L, Chen Q, Chang J, Liu J, Gu H, Huang Y, Chen Q, Li Z, Zhu Y, Miller H, Chen Y, Qiu L, Mei H, Hu Y, Gong Q,Liu C*. CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation. Cell Death and Differentiation.2021 Sep;28(9):2616-2633.IF=10.717

He M*, Saeed MB, Record J, Keszei M, Gonçalves Pinho L, Vasconcelos-Fontes L, D'Aulerio R, Vieira R, Oliveira MMS, Geyer C, Bohaumilitzky L, Thiemann M, Deordieva E, Buedts L, Matias Lopes JP, Pershin D, Hammarström L, Xia Y, Zhao X, Cunningham-Rundles C, Thrasher AJ, Burns SO, Cotta-de-Almeida V,Liu C, Shcherbina A, Vandenberghe P, Westerberg LS*.Overactive WASp in X-linked neutropenia leads to aberrant B-cell division and accelerated plasma cell generation.

J Allergy Clin Immunol. 2021 Aug 9:S0091-6749(21)01207-0. doi: 10.1016/j.jaci.2021.07.033. Online ahead of print.IF=10.793

Herrada AA*, Olate-Briones A, Rojas A,Liu C, Escobedo N, Piesche M*.Adipose tissue macrophages as a therapeutic target in obesity-associated diseases.Obes Rev. 2021 Jun;22(6):e13200.IF=9.213

Wang ZZ, Song J, Wang H, Li JX, Xiao Q, Yu Z, Wang ZC, Liu JX, Pan L, Yao Y, Chen CL, Lu X,Liu C, Gao P, Liu Z*. Stromal cells and B cells orchestrate ectopic lymphoid tissue formation in nasal polyps. Allergy. 2021 May;76(5):1416-1431.IF=13.146

Du Z^#, Chen A^#, Huang L, Dai X, Chen Q, Yang D, Li L, Miller H, Westerberg L, Ding Y, Tang X, Kubo M, Jiang L, Zhao X*, Wang H*,Liu C*. STAT3 couples with 14-3-3σ to regulate BCR signaling, B-cell differentiation, and IgE production. J Allergy Clin Immunol. 2021 May;147(5):1907-1923.e6.IF=10.228

Wang L^#, Jiang P^#, Zhao S, Liu H, Liu L, Mor G,Liu C*, Liao A*. The dynamic profile and potential function of B-cell subsets during pregnancy. Cell Mol Immunol. 2021 Apr;18(4):1082-1084.IF=22.096

Raynor JL,Liu C, Dhungana Y, Guy C, Chapman NM, Shi H, Neale G, Sesaki H, Chi H*.Hippo/Mst Signaling Coordinates Cellular Quiescence with Terminal Maturation in iNKT Cell Development and Fate Decisions. J Exp Med. 2020 Jun 1;217(6): e20191157.IF=11.743

Jing Y^#, Dai X^#, Yang L^#, Kang D, Jiang P, Li N, Cheng J, Li J, Miller H, Ren B, Gong Q, Yin W, Liu Z, Mattila P, Ning Q, Sun J, Yu B* andLiu C*.STING couples with PI3K to regulate actin reorganization during BCR activation. Science Advances. 2020 Apr 22; 6(17): eaax9455.*Co-corresponding author. IF=13.116

Jing Y^#, Kang D^#, Liu L, Huang H, Chen A, Yang L, Jiang P, Li N, Miller H,Liu Z, Zhu X, Yang J, Wang X, Sun J*,Liu Z*, Liu W*, Zhou X*,Liu C*.Dock2 couples with LEF-1 to regulate the expression of CD21 and B cell differentiation.Journal of Allergy and Clinical Immunology.2019 Nov; 144(5): p. 1377-1390 e4.*Co-corresponding author.IF=14.11

Xu C, Fang Y, Yang Z, Jing Y, Zhang Y,Liu C*,Liu W*.MARCKS Regulates Tonic and Chronic Active B Cell Receptor Signaling.Leukemia.2019 Mar;33(3):710-729.*Co-corresponding author.IF=9.944

Shi H,Liu C, Tan H, Li Y, Nguyen TM, Dhungana Y, Guy C, Vogel P, Neale G, Rankin S, Feng Y, Peng J, Tao W*, Chi H*. Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R–STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity. Immunity. 2018 Nov 20; 49 (5): 899-914.e6.IF=19.734

Huang L, Zhang Y, Xu C, Gu X, Niu L, Wang J, Sun X, Bai X, Xuan X, Li Q, Shi C, Yu B, Miller H, Yang G, Westerberg LS, Liu W, Song W, Zhao X*,Liu C*.Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin. PLos Biology. 2017 Aug 18; 15(8): e2001750.*Co-corresponding author. IF=9.797

Bai X, Zhang Y, Huang L, Wang J, Li W, Niu L, Jiang H, Dai R, Zhou L, Zhang Z, Miller H, Song W, Zhao X,Liu C*.The early activation of memory B cells from Wiskott-Aldrich syndrome patients is suppressed by CD19 down regulation. Blood.2016 Sep 29; 128(13):1723-34.IF=11.847

Zhang X^#, Dai R^#, Li W, Zhao H, Zhang Y, Zhou L, Du H, Luo G, Wu J, Niu L, An Y, Zhang Z, Ding Y, Song W,Liu C, Zhao X*.Abnormalities of follicular helper T-cell number and function in Wiskott-Aldrich syndrome. Blood.2016 Jun 23; 127(25):3180-91.IF=11.847

Song W*,Liu C, Seeley-Fallen MK, Miller H, Ketchum C, Upadhyaya A. Actin-mediated feedback loops in B-cell receptor signaling. Immunological Reviews. 2013 Nov; 256(1):177-89.IF=12.909

Liu C, Bai X, Wu J, Sharma S, Upadhyaya A,Dahlberg C, Westerberg L,Snapper S, Zhao X, Song W*.N-WASP is Essential for the Negative Regulation of B cell Receptor Signaling. Plos Biology. 2013 Nov; 11(11): e1001704.IF=11.771

Becker-Herman S^#, Meyer-Bahlburg A^#, Schwartz M^#, Jackson S, Hudkins K,Liu C, Sather B, Khim S, Liggitt D, Song W, Silverman G, Alpers C, Rawlings D*. WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.Journal of Experimental Medicine. 2011 Sep 26; 208(10):2033-42.IF=11.743

承担课题

1. 以B细胞代谢信号通路为靶向的抗新冠病毒药物的筛选 人畜共患传染病重症诊治全国重点实验室 2024年01月至2025年12月 10万 课题负责人

    

2. Wiskott-Aldrich综合征中的免疫缺陷：WASH蛋白在B细胞中的功能32311530061 国家自然科学基金委员会,国际(地区)合作与交流项目2023-05-01至2025-04-30 10万 课题负责人

1. 原发性免疫缺陷病高IgE的发病机制和治疗研究2021YFE0108200政府间国际科技创新合作 2021年07月 至2024年06月 273万 课题负责人

1. 儿童罕见病诊断关键技术与治疗靶点发现及转化医学研究  2023YFC2706300 科技部重点研发项目 2023年12月-2026年11月 20万 课题参与人

1. 各亚型慢性鼻炎发病机制研究2023YFC2507900 科技部重点研发项目 2023年11月-2026年10月234万 子课题负责人

    

2. 不同SARS-CoV-2变种感染中体液免疫的动态分析和应答机制研究NSFC82371784课题负责人国家自然科学基金面上项目2024-01-01至2027-12-3149万课题负责人

    

3. 新冠病毒感染机体免疫应答平衡及肺脏区域免疫特征研究 SRPG22-006 广州国家实验室项目200万课题参与人

    

4. 以WASp蛋白为靶向的慢性病和免疫缺陷的治疗 NSFC81861138002中瑞国际合作项目2018-01-01至2020-12-31300万课题负责人

    

5. 创新提升基因修饰T细胞治疗恶性实体瘤安全和有效性研究及临床转化2019YFC1316200 科技部慢病重点研发项目2019 年 12 月-2021 年 12 月 50万课题参与人

    

6. 血液系统的免疫疾病 NSFC 81722002国家自然科学基金优秀青年基金 2018年01月至 2020年12月 130万课题负责人

    

7. WASH通过促进STAT1磷酸化调控B细胞功能的机制研究NSFC 31970839 国家自然科学基金面上项目2020-01-01至2023-12-3158万课题负责人

    

8. CD23调控BCR信号和肌动蛋白重组机制的研究 NSFC 31500709国家自然科学基金青年基金项目 2016-01-01至2018-12-3122万课题负责人

    

    

   主要著作

   “B cell receptor signaling”, Methods in Molecular Biology, Springer， 2017

   “Tcell receptor signaling”, Methods in Molecular Biology, Springer， 2020 

   “Invariant Natural Killer T cells”, Methods in Molecular Biology, Springer， 2021