李岩，华中科技大学基础医学院三级教授，博士生导师，人畜共患传染病重症诊治全国重点实验室PI，药物靶点研究与药效学评价湖北省重点实验室PI,同济医院双聘教授，病原生物学系党支部书记，国家高层次青年人才，湖北省杰青，湖北省公共卫生青年拔尖人才。目前担任湖北省医学会微生物与免疫学分会副主任委员（候任主任委员）、教育部病毒学领域教学资源建设项目专家、湖北省生物物理学会常务理事、Wiley出版社VIEW Medicine副主编、Journal of Cellular Biochemistry编委以及The BMJ等二十余个期刊审稿人。于中国科学技术大学获得学士学位，新加坡南洋理工大学获得博士学位，在新加坡国立药物研发机构从事多年的创新药物研究工作。

课题组利用生物化学、分子生物学、结构生物学、人工智能、微生物学等多种方法探究包括耐药细菌、利什曼原虫、冠状病毒在内等重要人畜共患传染病的致病分子机制，并针对性的开发新型干预手段。以（共同）通讯/第一作者在Science、Lancet Microbe、Nature Communications、Nucleic Acids Research、Journal of Infection、Journal of Virology、FASEBJournal等期刊发表SCI论文40余篇，H因子26。参编高等教育出版社及科学出版社医学微生物学多本教材。主持国家自然科学基金新冠专项项目及面上项目、湖北省杰出青年基金、多个公司合作课题、武汉市卫健委应急科研专项等多个项目，作为骨干成员参与多个国家重点研发计划、湖北省创新研究群体等。课题组与业内多家领军企业有长期的合作，已申请药物专利5项，多个新药研发项目已经进入临床试验阶段，参与开发的产品销售至十余个国家，获得华为最佳创新合作奖。

代表性文章：

#Co-first author *Corresponding author

1. Peng, F., Ke, Z., Jin, H., Wang, W., Zhang, H.*, & Li, Y.* (2024). Structural insights into the regulation mechanism of Mycobacterium tuberculosis MftR. The FASEB Journal, 38, e23724.

2. Zhang, H.#, Zhou, K.#, Peng, F.#, Gao, Z.#, Song, G.#*, Hu, B., Chun, S., Xiao, J., Qian, M., Wu, J., Pan, K., Gao, F., Guo, M., Peng, C., Zou, G., Wu, J., Cai, K.*, & Li, Y.* (2024). Novel small-molecule inhibitors of SARS-CoV-2 main protease with nanomolar antiviral potency. Journal of Infection, 88(2), 211-214.

3. Zhang, H.#, Lv, P.#, Jiang, J., Liu, Y., Yan, R., Shu, S., Hu, B., Xiao, H., Cai, K., Yuan, S.*, & Li, Y.* (2023). Advances in developing of ACE2 derivatives against SARS-CoV-2. The Lancet Microbe, 4(5), e369-e378.

4. He, Z., Ke, Z., Wang, W., Liu, Y., Zhang, H.*, & Li, Y.* (2023). Biophysical and biochemical characterization of the binding of the MarR-like transcriptional regulator Saro_0803 to the nov1 promotor and its inhibition by resveratrol. Biomolecules, 13(3), 541.

5. Zhang, H.#, Hu, B.#, Lv, P.#, Liu, Y.#, Guo, M., Wu, Z., Zhou, K., Dai, M., Yu, X., Liu, Z., Yu, B., Xu, L., Guo, M.*, Cai, K.*, & Li, Y.* (2022). An ACE2-mimicking decoy inhibitor effectively neutralizes SARS-CoV-2 Omicron BA.5 variant. Viruses, 14(11), 2387.

6. Lv, P.#, Hu, B.#, Hua, R.#, Zhang, J.#, Zhang, H., Liu, Z., Xu, L., He, Z., Li, X., Guo, M., Pan, K., Zhang, Z., Zeng, Q., Wu, Z., Sun, L., Guo, M., Zhou, L., Xu, X., Yu, B., Xu, J., Yuan, S., Guo, M.*, Cai, K.*, Xia, Y.*, & Li, Y.* (2022). A novelly designed protein antagonist confers potent neutralization against SARS-CoV-2 variants of concern. Journal of Infection, 85(3), e72-e76.

7. Zhao, K.#, Ke, Z.#, Hu, H.#, Liu, Y., Li, A., Hua, R., Guo, F., Xiao, J., Zhang, Y., Duan, L, Yan, X., Gao, Y., Liu, B., Xia, Y.*, & Li, Y.* (2021). Structural basis and function of the N-terminus of SARS-CoV-2 nonstructural protein 1. Microbiology Spectrum, 9(1), e00169-21.

8. Xu, C.#, Ke, Z.#, Liu, C.#, Wang, Z.#, Liu, D., Zhang, L., Wang, J., He, W., Xu, Z., Li, Y., Yang, Y., Huang, Z., Lv, P., Wang, X., Han, D.*, Li, Y.*, Qiao, N.*, & Liu, B.* (2020). Systemic in silico screening in drug discovery for coronavirus disease (COVID-19) with an online interactive web server. Journal of Chemical Information and Modeling, 60(12), 5735-5745.

9. Lau, Q.#, Li, J.#, Sani, M.#, Sinha, S.#, Li, Y.#, Ng, F., Kang, C., Bhattacharjya, S., Separovic, F., Verma, C., & Chia, C.* (2018). Elucidating the bactericidal mechanism of action of the linear antimicrobial tetrapeptide BRBR-NH₂. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1860(8), 1517-1527.

10. Li, Y.#, Zhang, Z.#, Phoo, W.#, Loh, Y., Li, R., Yang, H., Jansson, A., Hill, J., Keller, T., Nacro, K.*, Luo, D.*, & Kang, C.* (2018). Structural insight into the inhibition of Zika virus NS2B-NS3 protease by a small-molecule inhibitor. Structure, 26(4), 555-564.e3.

11. Li, Y., Lee, M., Loh, Y., & Kang, C.* (2018). Secondary structure and membrane topology of Dengue Virus NS4A protein in micelles. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1860(2), 442-450.

12. Li, Y.#, Zhang, Z.#, Phoo, W., Loh, Y., Wang, W., Liu, S., Chen, M., Hung, A., Keller, T., Luo, D.*, & Kang, C.* (2017). Structural dynamics of Zika virus NS2B-NS3 protease binding to dipeptide inhibitors. Structure, 25(8), 1242-1250.e3.

13. Zhang, Z.#, Li, Y.#, Loh, Y., Phoo, W., Hung, A., Kang, C.*, & Luo, D.* (2016). Crystal structures of unlinked NS2B-NS3 protease from Zika Virus. Science, 354(6319), 1597-1600.

14. Phoo, W.#, Li, Y.#, Zhang, Z., Lee, M., Loh, Y., Tan, Y., Ng, E., Lescar, J., Kang, C.*, & Luo, D.* (2016). Structure of the NS2B-NS3 protease from Zika virus after self-cleavage. Nature Communications, 7, 13410.

15. Li, Y., Wong, Y., Lee, M., Li, Q., Wang, Q., Lescar, J., Shi, P., & Kang, C.* (2016). Secondary structure and membrane topology of the full-length Dengue Virus NS4B in micelles. Angewandte Chemie International Edition, 55(39), 12068-12072.

16. Li, Y., Wong, Y., Ng, F., Liu, B., Wong, Y., Poh, Z., Liu, S., Then, S., Lee, M., Ng, H., Huang, Q., Hung, A., Cherian, J., Hill, J., Keller, T., & Kang, C.* (2016). Escherichia coli topoisomerase IV E subunit and an inhibitor binding mode revealed by NMR spectroscopy. Journal of Biological Chemistry, 291(34), 17743-17753.

17. Li, Y.#, Li, Q.#, Wong, Y., Liew, L., & Kang, C.* (2015). Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1848(10 Pt A), 2244-2252.

18. Li, Y.#, To, J.#, Verdia-Baguena, C.#, Dossena, S., Surya, W., Huang, M., Paulmichl, M., Liu, D., Aguilella, V., & Torres, J.* (2014). Inhibition of the human respiratory syncytial virus small hydrophobic protein and structural variations in a bicelle environment. Journal of Virology, 88(20), 11899-11914.

19. Li, Y.#, Surya, W.#, Claudine, S., & Torres, J.* (2014). Structure of a conserved Golgi complex-targeting signal in coronavirus envelope proteins. Journal of Biological Chemistry, 289(18), 12535-12549.

20.Wong, L.#, Li, Y.#, Pillay, S., Frolova, L., & Pervushin, K.* (2012). Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1. Nucleic Acids Research, 40(12), 5751-5765.

热忱欢迎对传染病基础研究和药物转化研究有强烈兴趣的有志青年加入课题组。