朱莉萍，华中科技大学同济医学院病理生理学系，教授、博士生导师。中国病理生理学会理事、中国病理生理学会缺氧和呼吸专委会委员兼秘书、中国生理学会呼吸生理专委会委员、武汉病理生理学会秘书长。2008年获华中科技大学博士学位，并留校任教，2012年晋升为副教授，2017年晋升为教授。主要从事钙信号与呼吸系疾病，包括肺动脉高压、肺血管损伤的发病机制研究。先后主持国家自然科学基金青年基金、青年-面上连续资助项目、面上项目、国家自然科学基金优秀青年项目、教育部高等学校博士点专项科研基金、湖北省卫生健康委员会青年人才项目。研究论文发表于Circulation, Arterioscler Thromb Vasc Biol, Hypertension, J Am Heart Assoc, J Cell Sci, Biochim Biophys Acta-Mol Cell Res, Am J Physiology Lung Cell and Molecular Physiology等专业期刊。

主要学术论文：

1. Xiao R, Luo S, Zhang T, Lv Y, Wang T, Zhang J, Su Y, Ruiz M, Dupuis J,Zhu L*, Hu Q*. Peptide blocking self-polymerization of extracellular calcium-sensing receptor attenuates hypoxia-induced pulmonary hypertension.Hypertension. 2021;78(5):1605-1616. (IF=10.190)

2. Zhu L, Liu F, Hao Q, Feng T, Chen Z, Luo S, Xiao R, Sun M, Zhang T, Fan X, Zeng X, He J, Yuan P, Liu J, Ruiz M, Dupuis J, Hu Q*. Dietary geranylgeranyl pyrophosphate counteractsthe benefits of statin therapy in experimental pulmonary hypertension.Circulation. 2021;143(18):1775-1792. (IF=23.603)

3. Tan R, Li J, Liu F, Liao P, Ruiz M, Dupuis J,Zhu L*, Hu Q*. Phenylalanine induces pulmonary hypertension through calcium-sensing receptor activation.Am J Physiol Lung Cell Mol Physiol. 2020;319(6):L1010-L1020. (IF=4.418)

4. Zhu L^#, Xiao R^#, Zhang X, Lang Y, Liu F, Yu Z, Zhang J, Su Y, Lu Y, Wang T, Luo S, Wang J, Liu ML, Dupuis J, Jing ZC, Li T, Xiong W, Hu Q*. Spermine on endothelial extracellular vesicles mediates smoking-induced pulmonary hypertension partially through calcium-sensing receptor.Arterioscler Thromb Vasc Biol. 2019, 39(3):482-495. (IF=6.618)

5. Zeng X^#,Zhu L^#*, Xiao R, Liu B, Sun M, Liu F, Hao Q, Lu Y, Zhang J, Li J, Wang T, Wei X, Hu Q*. Hypoxia-induced mitogenic factor acts as a non-classical ligand of calcium-sensing receptor, therapeutically exploitable for hypoxic pulmonary hypertension.Hypertension. 2017, 69(5):844-854. (IF=7.017)

6. Xiao R^#, Su Y^#, Feng T, Sun M, Liu B, Zhang J, Lu Y, Li J, Wang T,Zhu L*, Hu Q*. Monocrotaline induces endothelial injury and pulmonary hypertension by targeting the extracellular calcium-sensing receptor.J Am Heart Assoc. 2017, 6(4): e004865.(IF=4.660)

7. Su Y^#,Zhu L^#, Yu X^#, Cai L^#, Lu Y, Zhang J, Li T, Li J, Xia J, Xu F*, Hu Q*. Mitochondrial transplantation attenuates airway hyperresponsiveness by inhibition of cholinergic hyperactivity.Theranostics. 2016, 6(8): 1244-1260. (IF= 8.854)

8. Chen F^#,Zhu L^#,Cai L, Zhang J, Zeng X, Li J, Su Y, Hu Q*. A stromal interaction molecule 1 variant up-regulates matrix metalloproteinase-2 expression by strengthening nucleoplasmic Ca²⁺signaling. Biochim Biophys Acta-Mol Cell Res. 2016, 1863(4): 617-629. (IF= 5.128)

9. Zhu L^#, Song S^#, Pi Y, Yu Y, She W, Ye H, Su Y, Hu Q*. Cumulated Ca²⁺spike duration underlines Ca²⁺oscillation frequency-regulated NF-kB transcriptional activity.J Cell Sci.2011, 124: 2591-2601. (IF= 6.111)

10. Chen T^#,Zhu L^#, Wang T, Ye H, Huang K, Hu Q*. Mitochondria depletion abolishes agonist-induced Ca²⁺plateau in airway smooth muscle cells: potential role of H₂O₂.Am J Physiol Lung Cell Mol Physiol. 2010, 298: L178-188.(IF=4.403)

11. Zhu L^#, Luo Y^#, Chen T^#, Chen F, Wang T, Hu Q*. Ca²⁺oscillation frequency regulates agonist-stimulated geneexpression in vascular endothelial cells.J Cell Sci. 2008; 121: 2511-2518. (IF= 6.111)

主持的科研项目：

1.国家自然科学基金面上项目，细胞间钙振荡信号传递与缺氧肺动脉高压发病机制，2022.01-2025.12，57万，主持

2.国家自然科学基金优秀青年项目，肺动脉高压，2020.01-2022.12，120万元

3.国家自然科学基金面上项目，核浆钙振荡在肺血管内皮间质转化中的作用机制，2018.01-2021.12，58万元

4.国家自然科学基金青年面上连续项目，VEGF诱导血管内皮细胞钙振荡在血管钙化中的作用及机制，2013.01-2016.12，80万元

5.国家自然科学基金青年项目，不规则钙振荡在氧化应激所致血管内皮损伤与保护中的作用及机制，2010.01-2012.12，20万元