朱铃强，华中科技大学二级教授，博士生导师，国家杰出青年基金获得者，中组部万人计划青年拔尖人才，教育部新世纪优秀人才、耶鲁大学博士后、华中卓越学者首席教授、国际杂志Journal of Alzheimer’s Disease Senior Editor、全国百篇优秀博士论文提名奖获得者，中国生理学会常务理事，中国神经科学学会常务理事，湖北省生理学会理事长，湖北省创新群体负责人，湖北省杰出青年基金获得者，湖北省医学首批青年拔尖人才。目前研究方向：神经精神疾病的发病机理和早期防治。主持国家自然科学基金杰青项目、重点项目、重大计划、国际合作（中德，中加）、海外港澳台基金共13项，科技部重点研发计划政府间合作专项3项、美国阿尔茨海默病协会（Alzheimer Association）新研究者基金一项。目前以通讯作者和第一作者发表SCI论文100余篇，其中包括Nature Neuroscience（2篇）、Neuron（3篇）、Cell Research、Mol Psychiatry（4篇）、Nature Communications（2篇）、Science Advances、Biological Psychiatry（2篇）、Cell Death & Differentiation等国际知名杂志。

研究方向

1、神经退行性疾病的发病机制与诊疗策略

2、脑损伤性（脑卒中、TBI等）疾病的发病机制与防治策略

3、脑机接口在神经疾病治疗和康复中的应用

发表论文（*通讯作者）

1. Fan HW#, He QH#, Zheng JQ#, Li LF, Chen JJ, Yin L, Zhong YL, Zhang P, Xu XR, Man HY, Lu YM, Tang ZP, Liu XD, Zhu LQ*, Liu D*. Noninvasive tactile stimulation engaging a thalamic–amygdala circuit ameliorates mood dysfunction in mouse models of depression-like behavior. Neuron. 2026 April; IF=15.0

2. Zhou Y, Li WL, Liu ZQ, Ai WQ, Kou JX, Fan HW, Han ZT, Hu YZ, Zhang HH, Jia JJ, Zeng Y, Guo ZY, Man HY, Lu YM*, Liu D*, Zhu LQ*. Spinal cord Tau pathology induces tactile deficits via c-Maf dysregulation of CCK neurons in Alzheimer’s disease. Nature Neuroscience. 2026 Feb; 29 (2):358–373. IF=20.0 (Research briefing on the same issue)

3. Chang JS, Huang HZ, Yuan M, Zhou Y, Liu D, Zhan KB*, Zhu LQ*. Alcohol addiction and Alzheimer's disease: a molecular collision course. Transl Psychiatry. 2025 Oct 17;15(1):410. IF=6.2.

4. Zhao Q, Chen BA, Ai WQ, Brazhe N, Liu D, Zhu LQ*, Wen M*. The immunological paradox of CD4⁺ T cells in traumatic brain injury (Review Article). Int J Surg. 2025 Oct 15. IF=10.1.

5. Li Z, Zhang J, Liu Z, Yu L, Yang C, Zhang L, Xiang Z, Hu F, Brazh N, Shu K*, Zhu LQ*, Liu D*. Brain somatic mutations in Alzheimer's disease: linking genetic mosaicism to neurodegeneration. Mol Neurodegener. 2025 Oct 9;20(1):104. IF=17.5

6. Zhou Y, Su T, Yuan M, Li WL, Zhou Y, Kou JX, Chang JS, Liu D, Chen L, Zhan K*, Zhu LQ*. A new lens on Alzheimer's disease: Insights into the Edinger-Westphal nucleus and its circuits. J Alzheimers Dis. 2025 Sep 11:13872877251372587. IF=3.1

7. Zheng K, Huang HZ, Liu D, Brazhe N, Chen J*, Zhu LQ*. Targeting the miR-96-5p/Cathepsin B Pathway to Alleviate Neuron-Derived Neuroinflammation in Alzheimer's Disease. MedComm. 2025. 2025 Sep 6;6(9):e70368. IF=10.7

8. Zhou Y, Li WL, Liu ZQ, Ai WQ, Kou JX, Fan HW, Han ZT, Hu YZ, Zhang HH, Jia JJ, Zeng Y, Guo ZY, Man HY, Lu YM*, Liu D*, Zhu LQ*. Spinal cord Tau pathology induces tactile deficits via c-Maf dysregulation of CCK neurons in Alzheimer’s disease. Nature Neuroscience. Accepted in principle. IF=20.0

9. Zhou Y, Kou JX, Zheng K, Guo ZX, Fan HW, Li WL, Chu LL, Yin JW, Liu LJ, Brazhe N, Xiang ZG, Hu F, Shu K*, Zhu LQ*, Liu D*. Epigenetic Regulation of DAPK1 and Netrin-1 Drives Diabetic Encephalopathy. Advanced Science. 2025 Aug 11:e02535. IF=14.1

10. Zhao JY, Zhou Y, Zhou CW, Zhan KB, Yang M, Wen M, Zhu LQ*. Revisiting the critical roles of reactive microglia in traumatic brain injury. Int J Surg. 2025 Jun 1;111(6):3942-3978. IF=10.1

11. Lai C, Chen Ki, Huang HZ, Huang X, Zhang J, Wang YB, Chen Z, Hu F, Guo ZY, Man H, Du H, Lu Y, Shu K*, Liu D*, Zhu LQ*. Historical loss weaken competitive behavior by remodeling ventral hippocampal dynamics. Cell Discovery. 2025 Feb 25;11(1):16. IF=13.0

12. Xu Q, Liu D, Zhu LQ*, Su Y*, Huang HZ*. Long non-coding RNAs as key regulators of neurodegenerative protein aggregation. Alzheimers Dement. 2025 Feb;21(2):e14498. IF=13.0

13. Rui TY, Huang HZ, Zheng K, Fan HW, Zhang J, Guo ZY, Man HY, Brazhe N, Semyanov A, Lu YM, Liu D*, Zhu LQ*. Tau Pathology Drives Disease-Associated Astrocyte Reactivity in Salt-Induced Neurodegeneration. Advanced Science. 2025 Jan 24:e2410799. IF=14.3

14. Zhang J, Yang CQ, Liu ZQ, Wu SP, Li ZG, Zhang LM, Fan HW, Guo ZY, Man HY, Li X, Lu YM, Zhu LQ*, Liu D*. Cpeb1 remodels cell type-specific translational program to promote fear extinction. Science Advances. 2025 Jan 10;11(2):eadr8687. IF=14.957

15. Wang MY, Zhou Y, Li WL, Zhu LQ*, Liu D*. Friend or foe: Lactate in neurodegenerative diseases. Ageing Res Rev. 2024 Aug 8:102452. IF=12.5

16. Zhu LS, Lai C, Zhou CW, Chen HY, Liu ZQ, Guo ZY, Man HY, Du HY, Lu YM, Hu F, Chen Z, Shu K*, Zhu LQ*, Liu D*. Postsynaptic lncRNA Sera/Pkm2 pathway orchestrates the transition from social competition to rank by remodeling the neural ensemble in mPFC. Cell Discovery. 2024 Aug 20;10(1):87. IF=13.0

17. Zhang X, Chen Z, Xiong Y, Zhou Q, Zhu LQ*, Liu D*. The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia. Neural Regen Res. 2025 Feb 1;20(2):402-415. IF=5.9

18. Zhang W, Liu D, Yuan M*, Zhu LQ*. The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases. Ageing Res Rev. 2024 online IF=13.6

19. Shen XY, Zhang J, Huang HZ, Li SD, Zhou L, Wu SP, Tang C, Huang X, Liu ZQ,  Guo ZY, Li X, Man HY, Lu YM, Zhu LQ*, Liu D*. Synapsin 2a/Synaptogyrin-3 Interaction regulates fear extinction in mice. J Clin Invest. 2024;134(4):e172802. IF=15.6

20. Zhou L, Yang C, Liu Z, Chen L, Wang P, Zhou Y, Yuan M, Zhou LT*, Wang X*, Zhu LQ*. Neuroprotective effect of the traditional decoction Tian-Si-Yin against Alzheimer's disease via suppression of neuroinflammation. J Ethnopharmacol. 2024 Mar 1;321:117569. IF=5.4

21. Huang HZ, Ai WQ, Wei N, Zhu LS, Liu ZQ, Zhou CW, Deng MF, Zhang WT, Zhang JC, Yang CQ, Hu YZ, Han ZT, Zhang HH, Jia JJ, Wang J, Liu FF, Li K, Xu Q, Yuan M, Man H, Guo Z, Lu Y, Shu K*, Zhu LQ*, Liu D*. Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer's disease mice. Protein Cell. 2023 Online. IF=21.1

22. Qian K, Jiang X, Liu ZQ, Zhang J, Fu P, Su Y, Brazhe NA, Liu D*, Zhu LQ*. Revisiting the critical roles of reactive astrocytes in neurodegeneration. Mol Psychiatry. 2023 Jul;28(7):2697-2706. IF=15.992

23. Zhou LT, Liu D, Kang HC, Lu L, Huang HZ, Ai WQ, Zhou Y, Deng MF, Li H, Liu ZQ, Zhang WF, Hu YZ, Han ZT, Zhang HH, Jia JJ, Sarkar AK, Sharaydeh S, Wang J, Man HY, Schilling M, Bertram L, Lu YM*, Guo ZY*, Zhu LQ*. Tau pathology epigenetically remodels the neuron-glial crosstalk in Alzheimer’s disease. Science Advances. 2023 Apr 21;9(16):eabq7105 IF=14.957

24. Wu MX, Chen ZY, Jiang M, Bao B, Li DL, Yin XP*, Wang XR*, Liu D*, Zhu LQ*. Friend or Foe: role of pathological tau in neuronal death. Mol Psychiatry. Mol Psychiatry. 2023 Jun;28(6):2215-2227. IF=15.992

25. Li X, Yu H, Zhang B, Li L, Chen W, Yu Q, Huang X, Ke X, Wang Y, Jing W, Du H, Li H, Zhang T, Liu L, Zhu LQ*, Lu Y*. Molecularly defined and functionally distinct cholinergic subnetworks. Neuron. 2022 Sep 14:S0896-6273(22)00796-6. IF=17.173

26. Zhang J, Liu D, Fu P, Liu ZQ, Lai C, Yang CQ, Chen K, Bao WD, Hu F, Du HY, Yang WL, Wang J, Man HY, Lu Y, Zhu LQ*. Social isolation reinforces aging-related behavioral inflexibility by promoting neuronal necroptosis in basolateral amygdala. Mol Psychiatry. 2022. 27(10):4050–4063. IF=15.992

27. Chen K, Lai C, Su Y, Bao WD, Yang LN, Xu PP*, Zhu LQ*. cGAS-STING-mediated IFN-I response in host defense and neuro-inflammatory diseases. Curr Neuropharmacol. 2021 Sep 24. IF=7.363.

28. Yang LN, Chen K, Yin XP, Liu D, Zhu LQ*. The Comprehensive Neural Mechanism of Oxytocin in Analgesia. Curr Neuropharmacol. 2021 Aug 26. IF=7.363.

29. Chen K, Jiang X, Wu M, Cao X, Bao W*, Zhu LQ*. Ferroptosis, a Potential Therapeutic Target in Alzheimer's Disease. Front Cell Dev Biol. 2021 Aug 5;9:704298. IF=6.684.

30. Zheng K, Hu F, Zhou Y, Zhang J, Zheng J, Lai C, Xiong W, Cui K, Hu Y, Han Z, Zhang H, Chen J, Man H, Liu D, Lu Y*, Zhu LQ*. MiR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease. Nat Commun. 2021 Mar 26;12(1):1903 IF=12.353.

31. Bao WD, Pang P, Zhou XT, Hu F, Xiong W, Chen K, Wang J, Wang F, Xie D, Hu YZ, Han ZT, Zhang HH, Wang WX, Nelson PT, Chen JG, Lu Y, Man HY, Liu D, Zhu LQ*. Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease. Cell Death and Differentiation. 2021;28:1548–1562. IF=10.717

32. Bao WD, Zhou XT, Zhou LT, Wang F, Yin X, Lu Y, Zhu LQ, Liu D. Targeting miR-124/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model. Aging Cell. 2020 Oct 17:e13235. IF=7.627.

33. Chen K, Yang LN, Lai C, Liu D, Zhu LQ*. Role of Grina/Nmdara1 in the Central Nervous System Diseases. Curr Neuropharmacol. 2020;18(9):861-867. IF=4.668.

34. Hou TY, Zhou Y, Zhu LS, Wang X, Pang P, Wang DQ, Liuyang ZY, Man H, Lu Y, Zhu LQ*, Liu D*. Correcting abnormalities in miR-124/PTPN1 signaling rescues taupathology in Alzheimer's disease. J Neurochem. 2020 Jan 17:e14961. IF=4.870.

35. Ma M, Xiong W, Hu F, Deng MF, Huang X, Chen JG, Man HY, Lu Y, Liu D*, Zhu LQ*. A novel pathway regulates social hierarchy via lncRNA AtLAS and postsynaptic synapsin IIb. Cell Res. 2020 Feb;30(2):105-118. IF=20.507.

36. Gilbert J, O'Connor M, Templet S, Moghaddam M, Di Via Ioschpe A, Sinclair A, Zhu LQ, Xu W, Man HY*. NEXMIF/KIDLIA knockout mouse demonstrates autism-likebehaviors, memory deficits, and impairments in synapse formation and function. J Neurosci. 2020 Jan 2;40(1):237-254. IF=6.074.

37. Zhou XT, Bao WD, Liu D, Zhu LQ*. Targeting the neuronal activity of prefrontal cortex: new directions for the therapy of depression. Curr Neuropharmacol. 2019 Nov 1. doi: 10.2174/1570159X17666191101124017. IF=4.568.

38. Zhou YF, Wang J, Deng MF, Chi B, Wei N, Chen JG, Liu D, Yin X*, Lu Y*, Zhu LQ*. The Peptide-Directed Lysosomal Degradation of CDK5 Exerts Therapeutic Effects against Stroke. Aging Dis. 2019 Oct 1;10(5):1140-1145. IF=4.232.

39. Ouyang Y, Li D, Wang H, Wan Z, Luo Q, Zhong Y, Yin M, Qing Z, Li Z, Bao B, Chen Z, Yin X*, Zhu LQ*. MiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats. Aging Cell. 2019 Dec;18(6):e13022. IF=7.627.

40. Zhu LS, Wang DQ, Cui K, Liu D, Zhu LQ*. Emerging Perspectives on DNA double-strand breaks in Neurodegenerative Diseases. Curr Neuropharmacol. 2019 17(12):1146-1157. IF=4.568.

41. Xie AJ, Hou TY, Xiong W, Huang HZ, Zheng J, Li K, Man HY, Hu YZ, Han ZT, Zhang HH, Wei N, Wang JZ*, Liu D, Lu Y*, Zhu LQ*. Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR-132/MeCP2 pathway. Aging Cell. 2019 Jun;18(3):e12929. IF=7.627.

42. Tang H, Ma M, Wu Y, Deng MF, Hu F, Almansoub H, Huang HZ, Wang DQ, Zhou LT, Wei N, Man HY, Lu Y, Liu D*, Zhu LQ*. Activation of MT2 receptor ameliorates dendritic abnormalities in Alzheimer’s disease via C/EBPα/miR-125b pathway. Aging Cell. 2019 Apr; 18(2):e12902. IF=7.627.

43. Su Y, Deng MF, Xiong W, Xie AJ, Guo J, Liang ZH, Hu B, Chen JG, Man HY, Lu Y, Liu D, Tang B*, Zhu LQ*. MicroRNA-26a/Death-associated protein kinase 1 signaling induces synucleinopathy and dopaminergic neuron degeneration in Parkinson’s disease. Biol Psychiatry. 2019;85(9):769-781. IF=11.982.

44. Li X, Chen W, Pan K, Li H, Pang P, Guo Y, Shu S, Cai Y, Pei L, Liu D, Afewerky HK, Tian Q, Zhu LQ*, Lu Y*. Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger-Westphal nucleus. Nat Neurosci. 2018 Sep;21(9):1239-1250. IF=21.136.

45. Li K, Wei Q, Liu FF, Hu F, Xie AJ, Zhu LQ*, Liu D*. Synaptic Dysfunction in Alzheimer's Disease: Aβ, Tau, and Epigenetic Alterations. Mol Neurobiol. 2018 55:3021-3032. IF=5.076.

46. Wang X, Liu D, Huang HZ, Wang ZH, Hou TY, Yang X, Pang P, Wei N, Zhou YF, Dupras MJ, Calon F, Wang YT, Man HY, Chen JG, Wang JZ, Hébert SS, Lu Y, Zhu LQ*. A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer's Disease. Biol Psychiatry. 2018:83;395-405. (Highlight in this issue and commentary by Dr. Wang-Xia Wang) IF=11.982.

47. Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ, Lu Y. Synaptic mechanism in Alzheimer's disease: a selective degeneration of an excitatory synaptic pathway in the CA1 hippocampus that controls spatial learning and memory in Alzheimer's disease. Mol Psychiatry. 2018 Feb;23(2):167.(Image) IF=11.640.

48. Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ*, Lu Y*. A novel mechanism of a memory loss in Alzheimer’s disease mice via degeneration of entorhinal-CA1 synapses. Mol Psychiatry. 2018: 23(2):199-210. IF=11.640.

49. Wang DQ, Fu P, Yao C, Zhu LS, Hou TY, Chen JG, Lu Y, Liu D*, Zhu LQ*. Long non-coding RNAs, novel culprits or bodyguards in neu-rodegenerative diseases. Molecular Therapy-Nucleic Acid. 2018, 10(2):269-276. IF=7.032.

50. Zhu H, Yan H, Tang N, Li X, Pang P, Li H, Chen W, Guo Y, Shu S, Cai Y, Pei L, Liu D, Luo MH, Man H, Tian Q, Mu Y*, Zhu LQ*, Lu Y*. Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses. Nat Commun. 2017 Nov 22;8(1):1676. IF=12.353.

51. Yang S, Jin H, Zhu Y, Wan Y, Opuku EN, Zhu LQ*, Hu B*. Diverse Functions and Mechanisms of Pericytes in Ischemic Stroke. Current Neuropharmacology, 2017;15(6):892-905. IF=4.068.

52. Liu D, Tang H, Li XY, Deng MF, Wei N, Wang X, Zhou YF, Wang DQ, Fu P, Wang JZ, Hebert SS, Chen JG, Lu Y, Zhu LQ*. Targeting the HDAC2/HNF-4A/miR0101b/AMPK pathway rescues tauopathy and dendritic abnormalities in Alzheimer’s disease Molecular Therapy. 2017 Mar 1;25(3):752-764.  IF=8.986.

53. An TH, He QW, Xia YP, Chen SC, Baral S, Mao L, Jin HJ, Li YN, Wang MD, Chen JG, Zhu LQ*, Hu B*. MiR-181b Antagonizes Atherosclerotic Plaque Vulnerability Through Modulating Macrophage Polarization by Directly Targeting Notch1. Mol Neurobiol. 2017 Oct;54(8):6329-6341. IF=5.076.

54. Liu YS, Dai X, Wu W, Yuan FF, Gu X, Chen JG, Zhu LQ*, Wu J*. The Association of SNAP25 Gene Polymorphisms in Attention Deficit/Hyperactivity Disorder: a Systematic Review and Meta-Analysis. Mol Neurobiol. 2017 Apr;54(3):2189-2200. IF=5.076.

55. Shu S, Zhu HZ, Tang N, Chen W, Li X, Li H, Pei L, Liu D, Mu Y, Tian Q, Zhu LQ*, Lu Y*. Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer’s Disease via Activation of DAPK1. J Neurosci. 2016 Oct 19;36(42):10843-10852. IF=5.970.

56. Xie AJ, Liu EJ, Huang HZ, Hu Y, Li K, Lu Y, Wang JZ*, Zhu LQ*. Cnga2 Knockout Mice Display Alzheimer's-Like Behavior Abnormities and Pathological Changes. Mol Neurobiol. 53(7), 4992-4999. IF=5.076.

57. Xiong YS, Liu FF, Liu D, Huang HZ, Wei N, Tan L, Chen JG, Man HY, Gong CX, Lu Y, Wang JZ, Zhu LQ. Opposite effects of two estrogen receptors on tau phosphorylation regulation through disparate effects on the miR-218/PTPA pathway. Aging Cell, 2015, 14: 867–877. IF=7.627.

58. Wang MD, Wang Y, Xia YP, Dai JW, Gao L, Wang SQ, Wang HJ, Mao L, Li M, Yu SM, Tu Y, He QW, Zhang GP, Wang L, Xu GZ, Xu HB, Zhu LQ*, Hu B*. High Serum MiR-130a Levels Are Associated with Severe Perihematomal Edema and Predict Adverse Outcome in Acute ICH. Mol Neurobiol. 2016 Mar;53(2):1310-21. IF=5.076.

59. Li K, Liu FF, He CX, Huang HZ, Xie AJ, Hu F, Liu D, Wang JZ*, Zhu LQ*. Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5. Mol Neurobiol. 2016 Jan;53(1):391-401. IF=5.076.

60. Liu D, Wei N, Man HY, Lu Y, Wang JZ, Zhu LQ. The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling. Cell Death & Differentiation. 2015 Apr;22(4):583-96. IF=10.717.

61. Hu J, Huang HZ, Wang X, Xie AJ, Wang X, Liu D, Wang JZ, Zhu LQ*. Glycogen synthase kinase-3 links the olfactory deficit to hippocampal impairments. Mol Neurobiol. 2015 Dec;52(3):1601-17. IF=5.076.

62. Liu DY, Shen XM, Yuan FF, Guo OY, Zhong Y, Chen JG, Zhu LQ* Wu J. The physiology of BDNF and its relationship with ADHD. Mol Neurobiol. 2015 Dec;52(3):1467-1476. IF=5.076.

63. Pei L, Shang Y, Jin H, Wang S, Wei N, Yan H, Wu Y, Yao C, Wang X, Zhu LQ*, Lu Y*. DAPK1-p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death. J Neurosci. 2014 May 7;34(19):6546-56. IF=5.970.

64. Wang X, Wang LP, Tang H, Shan WY, Wang X, Liu D, Wu YY, Tian Q, Wang JZ*, Zhu LQ*. Acetyl-l-carnitine rescues scopolamine-induced memory deficits by restoring insulin-like growth factor II via decreasing p53 oxidation. Neuropharmacology. 2014, 76(A) :80-87. IF=4.249.

65. Wu YY, Wang X, Tan L, Liu D, Liu XH, Wang Q, Wang JZ*, Zhu LQ*. Lithium Attenuates Scopolamine-Induced Memory Deficits with Inhibition of GSK-3β and Preservation of Postsynaptic Components. J Alzheimers Dis. 2013, 37(3):515-527. IF=3.476.

66. Tang H, Shen N, Jin HJ, Liu D*, Miao X*, Zhu LQ*. GSK-3β polymorphism discriminates bipolar disorder and schizophrenia: a systematic meta-analysis. Molecular Neurobiology. 2013,48(3):404-411. IF=5.076.

67. Xiong YS, Wang DL, Tan L, Wang X, Chen LM, Gong CX, Wang JZ*, Zhu LQ*. Inhibiton of glycogen synthase kinase-3 reverses tau hyperphosphorylation induced by Pin1 downregulation. CNS & Neurological Disorders - Drug Targets. 2013, 12(3):436-443. IF=2.084.

68. Zhao K, Wen R, Wang X, Pei L, Yang Y, Shang Y, Bazan N, Zhu LQ*, Tian Q*, Lu Y*. EPAC Inhibition of SUR1 Receptor Increases Glutamate Release and Seizure Vulnerability. J Neurosci. 2013,33(20):8861-8865. IF=5.970.

69. Peng CX, Hu J, Liu D, Hong XP, Wu YY, Zhu LQ*, Wang JZ*. Disease-modified GSK-3b intervention by melatonin arrests the pathology and memory deficits in Alzheimer’s animal model. Neurobiology of Aging. 2013, 34(6):1555-1563. IF=4.454.

70. Qu M, Jiang J, Liu XP, Tian Q, Chen LM, Yin G, Liu D, Wang JZ*, Zhu LQ*. Reduction and the intracellular translocation of EphB2 in Tg2576 mice and the effects of b-amyloid. Neuropathology and Applied Neurobiology. 2013 Oct;39(6):612-22. IF=6.059.

71. Zhong R, Yang B, Tang H, Zou L, Song R, Zhu LQ*, Miao XP*. Meta-analysis of the association between DCDC2 polymorphisms and risk of Dyslexia. Molecular Neurobiology. 2013;47(1):435-442. IF=5.076.

72. Wang X, Wang ZH, Wu YY, Tang H, Tan L, Wang X, Gao XY, Xiong YS, Liu D*, Wang JZ, Zhu LQ*. Melatonin attenuates scopolamine-induced memory/synaptic disorder by rescuing EPACs/miR-124/Egr1 pathsway. Molecular Neurobiology. 2013;47(1):373-381. IF=5.076.

73. Wang SH, Liao XM, Liu D, Hu J, Yin YY, Wang JZ*, Zhu LQ*. NGF Promotes Long-term Memory Formation by Activating Poly(ADP-ribose)polymerase-1. Neuropharmacology. 2012;63(6):1085-1092 IF=4.249.

74. Wu J, Xiao H, Sun H, Zou L, Zhu LQ*. Role of dopamine receprots in ADHD: a systematic meta-analysis. Molecular Neurobiology. 2012; 45(3):605-20. IF=5.076.

75. Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu WH, Zhu LQ*, Wang JZ*, Lu Y*. EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation. Neuron, 2012;73(4):774-788. IF=14.318.

76. Liao K, Liu D, Zhu LQ*. Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex. Neurosci Lett. 2012;507(1):22-26. IF=2.159.

77. Hu J, Wang X, Liu D, Wang Q, Zhu LQ*. Olfactory deficits induce neurofilament hyperphosphorylation. Neurosci Lett. 2012; 506(2):180-183. IF=2.159.

78. Zhou P, Chen Z, Zhao N, Liu D, Hu J, Guo ZY, Wang Q, Wang JZ*, Zhu LQ*. Acetyl-L-Carnitine attenuates homocysteine-induced Alzheimer-like histopathological and behavioral abnormalities. Rejuvenation Research. 2011, 14(6): 669-679. IF=3.220.

79. Jiang X, Tian Q, Wang Y, Zhou XW, Xie JZ, Wang JZ, Zhu LQ*. Acetyl-L-Carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. J Neurochem. 2011;118(5):864-878. IF=4.609.

80. Chen LM, Xiong YS, Kong FL, Qu M, Wang Q, Chen XQ, Wang JZ*, Zhu LQ*. Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. J Neurochem. 2012 Jan;120(1):157-64. IF=4.609.

81. Liu D, Zheng HY, Luo ZZ, Wang Q, Zhu LQ*. Effect of PP-2A on neurite outgrowth in neuronal cells. In Vitro Cell Dev-AN, 2010, 46(8): 702-707 IF=1.447.

82. Zhu LQ, Liu D, Hu J, Cheng J, Wang SH, Wang Q, Wang F, Chen JG, Wang JZ. GSK-3b inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation. J Neurosci. 2010;30(10):3624-33. IF=5.970.

83. Zhu LQ, Zheng HY, Peng CX, Liu D, Li HL, Wang Q, Wang JZ. Protein phosphatase 2A facilitates functional axonogenesis by dephosphorylating CRMP2. J Neurosci. 2010;30(10):3839-48. IF=5.970.

84. Yin YY, Liu H, Liu Z, Cong XB, Wang Q, Wang JZ*, Zhu LQ*. Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats. J Alzheimer’s Disease 2010;19(2):735-46. IF=3.476.

85. Shi HR, Zhu LQ*, Wang SH, Liu XA, Tian Q, Zhang Q, Wang Q, Wang JZ*. (2008). 17 β-estradiol attnuates glycogen synthase kinase-3β activation and tau hyperphosphorylation in Akt-independent manner. J Neural Transmission 115(6):879-888. IF=2.776.

86. Liu XA, Zhu LQ*, Zhang Q, Shi HR, Wang SH, Wang Q, Wang JZ*. (2008). Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A. Neurochemical Res 2008 Sep;33(9):1811-20. IF=2.772.

87. Zhu LQ, Wang SH, Liu D, Yin YY, Tian Q, Wang XC, Wang Q, Chen JG, Wang JZ (2007). Activation of glycogen synthase kinase-3 inhibits long term potentiation with synapse-associated impairments. J Neurosci 27:12211-12220. IF=5.970.

88. Wang SH, Zhu LQ, Wang Q, et al. (2007). Inhibition of Melatonin Biosynthesis Induces Neurofilament Hyperphosphorylation with Activation of Cyclin-dependent Kinase 5. Neurochem Res 32(8):1329-1335. IF=2.772.

89. Zhu LQ, Wang SH, Ling ZQ, et al. 2005. Inhibition of melatonin biosynthesis activates protein kinase A and Alzheimer-like tau hyperphosphorylation in rat. Chinese Medical Science J 20(2):83-87.

90. Zhu LQ, Wang SH, Ling ZQ, et al. (2004). Effect of inhibiting melatonin biosynthesis on spatial memory retention and tau phosphorylation in rat. J Pineal Res 37 (2):71-77. IF=11.613.

     

     

    承担项目

    2025 年，国家自然科学基金委员会与俄罗斯科学基金会合作研究项目，W2512096，神经元Tau病理与星形胶质细胞反应性互作在阿尔茨海默病神经-星形胶质-血管耦合障碍中的作用，150万元，负责人，2026.01-2028.12

    2025 年，昌平国家实验室专项，100万元，负责人，2025.9-2026.8

    2023 年，国家重点研发计划政府间/港澳台专项项目，2023YFE0117600，阿尔茨海默病内嗅皮层突触退变机理研究，150万元，负责人，2024.01-2026.12

    2023 年，国家自然科学基金委国家杰出青年基金，82325017，阿尔茨海默病发病机理研究，400万元，负责人，2024.1-2028.12

    2022年，湖北省自然科学基金创新群体项目，2022CFA004，50万元，负责人，2022.10.1-2025.9.30

    2021年，科技部 科技创新2030-脑科学与类脑科学 重大专项，2022ZD0211800，SCD转化为阿尔茨海默病新机制及其预警和干预体系的研究，348.5万元，骨干，2022.7-2027.6

    2020年，国家自然科学基金委重点项目，82030032，Tau病变在老年痴呆注意缺陷中的作用和机制研究，297万元，负责人，2021.1-2025.12.

    2019年，国家重点研发计划政府间/港澳台专项项目，2019YFE0121200，miRNA在老年痴呆稳态突触失衡中的作用，300万元，负责人，2020.12-2023.11

    2018年,国家自然科学基金委员会海外及港澳学者合作研究基金延续性项目, 81829002, miR-138/Nrgn信号通路在智障相关蛋白KIDLIA缺失所致自闭症样社交异常及突触紊乱中的作用和机理,180万元,第一参与人(境内负责人),2019.1-2022.12.

    2017年，国家自然科学基金面上项目动物模型专项，81771150，运用光遗传可调控性转基因小鼠模型研究基底前脑-海马DG胆碱能神经环路损伤在阿尔茨海默病早期模式分别障碍中的作用，80万元，负责人，2018.1.1-2021.12.31

    2017年，国家自然科学基金创新群体项目，31721002，记忆神经环路研究群体，1050万元，参与人，2018.1.1-2023.12.31

    2017年，国家自然科学基金委员会（NSFC）与德国科学基金会（DFG）合作研究项目，81761138043，微小RNA调节网络在阿尔茨海默病神经环路功能障碍中的作用(MiRNetAD)，180万元，负责人，2018.1.1-2020.12.31

    2016年，国家自然科学基金重大计划，91632114, 长链非编码mSYT-AS异常在阿尔茨海默病ECIIPN-CA1PV环路功能障碍中作用研究，60万元，负责人 2017.1.1-2019.12.31

    2015年，国家自然科学基金面上项目，31571039，长链非编码RNA AK036689在阿尔茨海默病早期海马突触环路功能障碍中的作用，64万元，负责人，2016.1.1-2019.12.31.

    2015年，国家特支计划青年拔尖人才专项基金，190万元

    2015年，华中科技大学首届青年学术团队专项基金，60万元/年持续资助

    2014年，湖北省杰出青年基金, 2014CFA017, 组蛋白去乙酰化酶2调控AD脑内淀粉样蛋白生成和tau病变的机制,10万元，负责人，2014.1-2016.12.

    2014年,国家自然科学基金委员会海外及港澳学者合作研究基金, 81428009, 智障相关蛋白KIAA202在神经元发育及突触形成中的作用,20万元,第一参与人(境内负责人),2015.1-2016.12.

    2013年，国家自然科学基金委员会（NSFC）与加拿大魁北克医学研究基金会（FRQS）合作研究项目，81361120245，整体水平研究EPAC/miR-124信号通路在阿尔兹海默发病中的作用和机制，100万元，负责人 2013.1.-2015.12.31

    2012年，中国科技部-加拿大国际合作专项基金，2011DFG33250，运用新型基因技术探索糖原合酶激酶3在脑功能和疾病中作用的合作研究，170万元，负责人 2012.4-2015.3

    2011年，美国阿尔茨海默协会基金，NIRG-11-205737，Role of EphB2 signal in tau pathology in Alzheimer's Disease， 10万美金，负责人（目前中国获得该基金的只有三人） 2011.10-2013.9

    2011年，国家自然科学基金重大计划，91132725, 嗅觉环境变化对内嗅皮层-海马环路功能的影响及在阿尔茨海默病样记忆障碍中的作用80万元，负责人 2012.1.1-2014.12.31

    2010 年，教育部新世纪优秀人才支持计划，NCET-10-0421，神经细胞粘附分子唾液酸化失调引起阿尔茨海默病突触病变的分子机理， 50万，负责人 2011.5-2014.4

    2009年，国家自然科学基金面上基金，30971478，雌激素受体beta在衰老相关记忆障碍中的作用和机制，31万元，负责人 2010.1.1-2012.12.31

    2009年，华中科技大学首届学术新人奖人才基金，20万，负责人

    2008年，国家自然科学基金青年基金，30800342，糖原合酶激酶3在阿尔茨海默病突触病变中的作用和机制，20万元，负责人 2009.1.1-2011.12.31

    专利

    朱铃强，王雄，王玉田，刘丹，黄和周。一种防治老年痴呆的药物。专利号：2014106681340，授权日，2017.6.16日

     

    朱铃强，刘丹，熊婉，马梅，黄宪。一种多肽及其在改善低社会等级对机体不良影响中的应用。专利号：201811638624.0，授权日：2020.9.8日

     

    朱铃强，邓曼菲，刘丹，周雅帆，谢傲吉。一种小分子多肽及其在制备防治帕金森综合症药物中的应用。专利号：201810039699.0，授权日：2021.3.30日

     

    朱铃强，周雅帆，邓曼菲，刘丹，汪晶。一种小分子多肽及其在制备防治缺血性脑卒中药物中的应用。专利号：201710875498X，授权日：2021.6.28日

    朱铃强，侯童瑶，刘丹，胡凡，韦娜。一种透脑性多肽及其在制备防治老年痴呆药物中应用。专利号：2018114563005，授权日：2021.8.23日

    朱铃强，胡凡，刘丹，郑洁，周杨。一种多肽及其在改善老年痴呆学习记忆障碍中的应用。专利号：

    朱铃强，沈细亚，刘丹，张娟。一种创伤后应激障碍模型小鼠的构建及其应用。专利号：2022113265147，授权日：2024.12.10日