陈伟，教授，博士生导师，国家海外高层次青年人才（2022），湖北省“杰青”（2022），湖北省“百人计划”（2021）入选者。陈教授2009年于武汉大学化学基地班专业获理学学士学位，2014年在浙江大学化学系获得博士学位。2015-2018年在美国国立卫生研究院National Institutes of Health（NIH）陈小元教授课题组从事博士后研究，2018-2020年于麻省理工学院（Massachusetts Institute of Technology, MIT）Robert S. Langer教授（美国三院院士，2021年增选为中国工程院外籍院士）课题组任研究科学家（Research Scientist）。2021年加入华中科技大学同济医学院基础医学院药理学系，任教授，兼任Chinese Chemical Letters和MedComm – Biomaterials and Application青年编委，以及Journal of Nanobiotechnology客座编辑。同时担任湖北省药理学会理事以及中国抗癌协会第三届纳米肿瘤学专业委员会委员。

研究方向：智能器件，仿生修饰，转化医学，诊断治疗，药物可控释放，长效药物制剂

联系方式：weichen86@hust.edu.cn/weichensci@hotmail.com,欢迎材料，化学，生物，医学，工程等相关专业学生报考。

英文主页：WeiChen_WorldChanging Group

ORCID:0000-0003-3611-2760

陈教授长期从事利用生物启发技术构建药物制剂及智能器件用于疾病诊断治疗的研究。围绕增强药物疗效、提升病人依从性以及增加生物样本采样准确性等关键临床问题，陈教授基于自身的研究背景，学习并借鉴自然界中存在生物原理，发展了系列生物启发智能系统：（1）模拟生物硬组织形成，制备仿生矿化药物制剂，逆转了肿瘤耐药性；（2）模拟生物自发驱动，开发了生物表面修饰及改性技术，调控生物体定向迁移特性；（3）模拟多刺生物防御，成功构建了血糖响应型微针贴片，便利、长效调控病人血糖；（4）模拟刺头蠕虫寄生，创造超强生物粘附微针药片，实现了大分子药物高效口服递送；（5）模拟鸟类舌尖采集食品，发展可富集病毒微针咽拭子提高了流行病病原体检测准确性。已发表SCI论文40余篇，独立一作12篇，共同一作2篇，通讯（含共同）作者17篇，包括Device (2023), Adv. Drug Deliv. Rev. (2023), ACS Nano (2023), Adv. Sci. (2023), J. Control. Release (2023) Sci. Adv. (2022), Nano Lett. (2022), Adv. Mater. (2022), ACS Nano (2022), J. Nanobiotechnology (2022), Theranostics (2021)，Matter (2020), Nano today (2020), Nano Lett. (2019), Adv. Drug Deliv. Rev. (2018), Nat. Commun. (2017), ACS nano (2017), Small (2014,2015), J. Control. Release (2015)等，其中影响因子大于11的论文20篇，7项专利已获授权。以重要骨干身份参与了美国国立卫生研究院研究计划，以及麻省理工学院-诺和诺德联合研究项目，成果被NIH和MIT重点推荐，并被Cell出版社以及多家媒体相继转载。相关工作荣获首批湖北省实验室亮点科技成果及第十八届“挑战杯”全国一等奖。陈教授工作已展现出较高的商业及临床转化潜力，被糖尿病药物公司诺和诺德邀请参与药物制剂的研发，相关制剂已进入临床试验阶段。

部分代表性工作概览

近期新闻：

基础医学院在“挑战杯”全国决赛主体赛中荣获一等奖

华中科技大学同济医学院陈伟教授ADDR：超声可触发/皮肤相关的微型器件用于智能药物递送与医学诊断

专访华科大陈伟丨高科技、低成本，搅拌磁子化身「磁性机器人」，解决临床肠道疾病精准靶向治疗难题

华中科大-陈伟&NUS-陈小元︱受小肠绒毛启发的数学工程化底纹贴片用于各类粘膜高效生物标志物富集与药物快速沉积

Chemical Engineering Journal基础医学院陈伟教授团队最新成果：基于光降解的铁交联海藻酸钠微针贴片用于干燥病治疗

受自加热食品启发，华科陈伟教授团队研发可触发微针系统，实现高效局部药物递送

华科大本科生团队一项科研成果显示变虫为宝——“灭活血吸虫虫卵”或可辅助治疗1型糖尿病

Adv Sci综述︱华中大陈伟团队评述时空精准技术实现神经系统疾病的按需干预

华中大陈伟/王婷团队《J. Nanobiotechnol.》：尖端搭载无佐剂日本血吸虫虫卵的不对称微针贴片治疗1型糖尿病

陈小元/王琳/王征/陈伟ACS Nano:微针图案，用于疫苗接种

华中大陈伟教授、麻省理工Traverso教授等《Sci. Adv.》：生物大分子的口服递送策略-动态全向粘附微针阵列系统

感染性皮肤伤口的修复|华中科技大学王琳/王征/陈伟教授团队《Nano Letters》：仿生定向牵引抗菌丝胶微针高效修复感染性全层皮肤缺损

华中科技大学基础医学院陈伟教授等在Theranostics综述搭载活性物质的智能微针系统在生物医学中应用

陈伟教授团队《Advanced Materials》综述未来科技改变生活：轻便小型智能可穿戴器件的创新与发展

华中科技大重磅成果！自发富集病毒微针拭子，减少新冠检测的“假阴性”！

可自发调节的糖尿病治疗贴片美国国立卫生研究院陈小元团队陈伟博士《Nature Communications》

代表性论文：

1. Zeng, Qi#; Li, Guanyue#; Chen, Wei*, Ultrasound-activatable and skin-associated minimally invasive microdevices for smart drug delivery and diagnosis,Adv. Drug Deliv. Rev.2023, 115133.

2. Gong, Yusheng; Tong, Shuai; Li, Xixuan; Chen, Xiuli; Liu, Yushuang; Li, Nan; Xu, Jiarong; Xu, Rengui; Guo, Yusong; Xiao, Fei; Chen, Xiaoyuan*; Chen, Wei*, Intestinal villi-inspired mathematically base-layer engineered microneedles (IMBEMs) for effective molecular exchange during biomarker enrichment and drug deposition in diversified mucosa,ACS Nano2023,7, 15696-15712.

3. Xu, Jiarong; Zeng, Qi; Chen, Xiuli; Guo, Honglian; Gong, Yusheng; Xu, Rengui; Cao, Peng; Wei, Chunyu; Xiao, Fei; Jiang, Dawei*; Chen, Wei*, Iron (III) cross-linked alginate microneedle patch for xerosis treatment based on controllable photodegradation,Chem. Eng. J.2023, 145672.

4. Chen, Xiuli; Gong, Yusheng; Chen, Wei.*, Advanced temporally-spatially precise technologies for on-demand neurological disorder intervention,Adv. Sci.2023,10(14), e2207436.

5. Wang, Zheng#*; Li, Qilin#; Cao, Peng#; Zhang, Jiao; Wu, Di; Xu, Rengui; Zhang, Yan; Xu, Yunruo; Liang, Tao; Chen, Wei*; Wang, Lin*; Chen, Xiaoyuan*, A biomimetic helical robot actuated by rotating magnetic field for targeted navigation and in situ prodrug activation to treat intestinal diseases,Device2023,1, 10064.

6. Xu, Rengui; Guo, Honglian; Chen, Xiuli; Xu, Jiarong; Gong, Yusheng; Cao, Peng; Wei, Chunyu; Xiao, Fei; Wu, Di; Chen, Wei*; Wang, Lin*; Wang, Zheng*, Smart hydrothermally responsive microneedle for topical tumor treatment,J. Control. Release2023,358, 566-578.

7. Dai, Jun#; Wei, Siming#; Xu, Jiarong#; Xue, Huiying; Chen, Zhaojun; Wu, Meng; Chen, Wei*; Lou, Xiaoding; Xia, Fan*; Wang, Shixuan*, Microneedle device delivering aggregation-induced emission photosensitizers for enhanced metronomic photodynamic therapy of cancer,ACS Appl. Mater. Interfaces2023,15, 16526–16538.

8. Yu, Yajie#; Lv, Bing#; Wu, Juntao; Chen, Wei*, Mussel-based biomimetic strategies in musculoskeletal disorder treatment: from synthesis principles to diverse applications,Int. J. Nanomedicine2023,18, 455-472.

9. Liu, Yuan; Huang, Ting; Qian, Zhiyong*; Chen, Wei*, Extensible and swellable hydrogel-forming microneedles for deep point-of-care sampling and drug deployment,Chin. Chem. Lett.2023, 108103.

10. Chen, Wei; Wainer, Jacob; Ryoo, Si Won; Qi, Xiaoyue; Chang, Rrong; Li, Jason; Lee, Seung Ho; Min, Seokkee; Wentworth, Adam; Collins, Joy; Tamang, Siddartha; Ishida, Keiko; Hayward, Alison; Langer, Robert; Traverso, Giovanni*, Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery,Sci. Adv.2022,8, eabk1792.

11. Chen, Wei*; Wang, Zheng*; Wang, Lin*; Chen, Xiaoyuan*, Smart chemical engineering‐based lightweight and miniaturized attachable systems for advanced drug delivery and diagnostics,Adv. Mater.2022,34(6), 2106701.

12. Huang, Haoming#; Hu, Dian#; Chen, Zhuo#; Xu, Jiarong; Xu, Rengui; Gong, Yusheng; Fang, Zhengming; Wang, Ting*; Chen, Wei*, Immunotherapy for type 1 diabetes mellitus by adjuvant-free Schistosoma japonicum-egg tip-loaded asymmetric microneedle patch (STAMP),J. Nanobiotechnology2022,20(1), 377.

13. Li, Qilin#; Xu, Rengui#; Fan, Huiling#; Xu, Jiarong; Xu, Yunruo; Cao, Peng; Zhang, Yan; Liang, Tao; Zhang, Yang; Chen, Wei*; Wang, Zheng*; Wang, Lin*; Chen, Xiaoyuan*, Smart mushroom-inspired imprintable and lightly detachable (MILD) microneedle patterns for effective COVID-19 vaccination and decentralized information storage,ACS Nano2022,16(5), 7512-7524.

14. Deng, Yan#; Yang, Cheng#; Zhu, Yuanyuan; Liu, Wenyu; Li, Heli; Wang, Liping; Chen, Wei*; Wang, Zheng*; Wang, Lin*, Lamprey-teeth-inspired oriented antibacterial sericin microneedles for infected wound healing improvement,Nano Lett.2022,22(7), 2702-2711.

15. Liu, Yuan; Guo, Honglian; Xu, Rengui; Chen, Wei*, Smart intraoral systems for advanced drug delivery,MedComm – Biomaterials and Applications2022,1, e19.

16. Cai, Bo#; Gong, Yusheng#; Wang, Zheng*; Wang, Lin*; Chen, Wei*, Microneedle arrays integrated with living organisms for smart biomedical applications,Theranostics2021,11(20), 10012-10029.

17. Chen, Wei#; Huang, Ting#; Shi, Kun; Chu, Bingyang; Qian, Zhiyong*, Chemotaxis-based self-accumulation of surface-engineered mitochondria for cancer therapeutic improvement,Nano Today2020,35, 100966.

18. Chen, Wei*; Cai, Bo; Geng, Zhi; Chen, Fenghua; Wang, Zheng*; Wang, Lin*; Chen, Xiaoyuan*, Reducing false negatives in COVID-19 testing by using microneedle-based oropharyngeal swabs,Matter2020,3(5), 1589-1600.

19. Chen, Wei; Shi, Kun; Chu, Bingyang; Wei, Xiawei*; Qian, Zhiyong*, Mitochondrial surface engineering for multidrug resistance reversal,Nano Lett.2019,19(5), 2905-2913.

20. Chen, Wei; Yung, Bryant C; Qian, Zhiyong*; Chen, Xiaoyuan*, Improving long-term subcutaneous drug delivery by regulating material-bioenvironment interaction,Adv. Drug Deliv. Rev.2018,127, 20-34.

21. Chen, Wei; Tian, Rui; Xu, Can; Yung, Bryant C.; Wang, Guohao; Liu, Yijing; Ni, Qianqian; Zhang, Fuwu; Zhou, Zijian; Wang, Jingjing; Niu, Gang; Ma, Ying; Fu, Liwu*; Chen, Xiaoyuan*, Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy,Nat. Commun.2017, 1777.

22. Chen, Wei; Wang, Guohao; Yung, Bryant C.; Liu, Gang; Qian, Zhiyong*; Chen, Xiaoyuan*, Long-acting release formulation of exendin-4 based on biomimetic mineralization for type 2 diabetes therapy,ACS Nano2017,11(5), 5062-5069.

23. Chen, Wei; Wang, Fang; Zhang, Xu; Hu, Jing; Wang, Xiaokun; Yang, Ke; Huang, Liyan; Xu, Meng; Li, Qingshan; Fu, Liwu*, Overcoming ABCG2-mediated multidrug resistance by a mineralized hyaluronan–drug nanocomplex,J. Mater. Chem. B2016,4(41), 6652-6661.

24. Rao, Yuefeng#; Chen, Wei#; Liang, Xingguang; Huang, Yongzhuo; Miao, Jing; Liu, Liu; Lou, Yan; Zhang, Xingguo; Wang, Ben; Tang, Ruikang; Chen, Zhong; Lu, Xiaoyang*, Epirubicin‐loaded superparamagnetic iron‐oxide nanoparticles for transdermal delivery: cancer therapy by circumventing the skin barrier,Small2015,11(2), 239-247.

25. Chen, Wei; Liu, Xueyao; Xiao, Yun; Tang, Ruikang*, Overcoming multiple drug resistance by spatial–temporal synchronization of epirubicin and pooled siRNAs,Small2015,11(15), 1775-1781.

26. Chen, Wei; Fu, Liwu*; Chen, Xiaoyuan*, Improving cell-based therapies by nanomodification,J. Control. Release2015,219, 560-575.

27. Chen, Wei; Wang, Guangchuan; Tang, Ruikang*, Nanomodification of living organisms by biomimetic mineralization,Nano Res.2014,7(10), 1404-1428.

28. Chen, Wei; Liu, Xueyao; Xiao, Yun; Chen, Yanhong; Wang, Guangchuan; Liu, Cuilian; Xu, Xurong; Tang, Ruikang*, Nano regulation of cisplatin chemotherapeutic behaviors by biomineralization controls,Small2014,10(18), 3644-3649.

29. Chen, Wei; Xiao, Yun; Liu, Xueyao; Chen, Yanhong; Zhang, Jiaojiao; Xu, Xurong; Tang, Ruikang*, Overcoming cisplatin resistance in chemotherapy by biomineralization,Chem. Commun.2013,49(43), 4932-4934.

30. Lv, Qiying#; Li, Xiaoye#; Tian, Xin; Fu, Da‐an; Liu, Huan; Liu, Jia; Song, Yu; Cai, Bo; Wang, Jian; Su, Qiangfei; Chen, Wei; Zou, Meizhen; Xiao, Fei; Wang, Shuai*; Wang, Zheng*; Wang, Lin*, A degradable and biocompatible supercapacitor implant based on functional sericin hydrogel electrode,Adv. Energy Mater.2023, 2203814.

31. Lee, Seung Ho; Wan, Qianqian; Wentworth, Adam; Ballinger, Ian; Ishida, Keiko; Collins, Joy E; Tamang, Siddartha; Huang, Hen-Wei; Li, Canchen; Hess, Kaitlyn; Lopes, Aaron; Kirtane, Ameya; Lee, Jung Seung; Lee, Sejun; Chen, Wei; Wong, Kaithlyn; Selsing, George; Kim, Hyunjoon; Buckley, Stephen; Hayward, Alison; Langer, Robert; Traverso, Giovanni*, Implantable system for chronotherapy,Sci. Adv.2021,7(48), eabj4624.

32. Zhou, Zijian; Chan, Alexander; Wang, Zhantong; Huang, Xiaolin; Yu, Guocan; Jacobson, Orit; Wang, Sheng; Liu, Yijing; Shan, Lingling; Dai, Yunlu; Shen, Zheyu; Lin, Lisen; Chen, Wei; Chen, Xiaoyuan*, Synchronous chemoradiation nanovesicles by x-ray triggered cascade of drug release,Angew. Chem. Int. Ed. Engl.2018,57(28), 8463-8467.

33. Xia, Yuqiong*; Wang, Xiaofei; Cheng, He; Fang, Mei; Ning, Pengbo; Zhou, Yulu; Chen, Wei; Song, Hongjin, A polycation coated liposome as efficient siRNA carrier to overcome multidrug resistance,Colloids Surf. B Biointerfaces2017,159, 427-436.

34. Wang, Zhe; Zhang, Fuwu; Wang, Zhantong; Liu, Yijing; Fu, Xiao; Jin, Albert; Yung, Bryant C; Chen, Wei; Fan, Jing; Yang, Xiangyu; Niu, Gang; Chen, Xiaoyuan*, Hierarchical assembly of bioactive amphiphilic molecule pairs into supramolecular nanofibril self-supportive scaffolds for stem cell differentiation,J. Am. Chem. Soc.2016,138(45), 15027-15034.

35. Liu, Zhaoming; Xiao, Yun; Chen, Wei; Wang, Yang; Wang, Ben; Wang, Gguangchuan; Xu, Xurong; Tang, Ruikang*, Calcium phosphate nanoparticles primarily induce cell necrosis through lysosomal rupture: the origination of material cytotoxicity,J. Mater. Chem B.2014,2(22), 3480-3489.

36. Wang, Yang; Xiao, Yun; Zhou, Hangyu; Chen, Wei; Tang, Ruikang*, Ultra-high payload of doxorubicin and pH-responsive drug release in CuS nanocages for a combination of chemotherapy and photothermal therapy,RSC Adv.2013,3(45), 23133-23138.

37. Du, Yuhao#; Zhang, Dan#; Chen, Wei; Zhang, Ming; Zhou, Yangyang; Zhou, Xiang*, Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition,Bioorgan. Med. Chem.2010,18(3), 1111-1116.

38. Wang, Guangchuan; Li, Xiaofeng; Mo, Lijuan; Song, Zhiyong; Chen, Wei; Deng, Yongqiang; Zhao, Hui; Qin, Ede; Qin, Chengfeng*; Tang, Ruikang*, Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration,Angew. Chem. Int. Ed. Engl.2012,51(42), 10576-10579.