胡壮丽

Email：zlhu916@hust.edu.cn

个人简介： 博士，华中科技大学同济医学院药理系教授，武汉市药理学会理事。1999年毕业于原同济医科大学临床医疗专业，获学士学位。2004-2005在美国俄亥俄州立大学心肺实验室学术交流一年，2008年获得华中科技大学博士学位。主要从事离子通道、神经胶质细胞与情感障碍性疾病的研究。作为负责人主持国家自然科学基金三项，湖北省科技研究与开发计划项目一项，校创新基金两项，并参与多项国家级和省级研究项目。以第一和通讯作者在Antioxid Redox Signal，Neuropharmacology, Glia, J. Biol. Chem, Sci Rep等杂志发表文章10余篇。

研究方向：神经药理

承担的主要科研项目：

1. 国家自然科学基金青年基金 心肌酸敏感离子通道（ASICs）：治疗心肌缺血的新靶点（No. 30901804）；主持（已结题）

2. 国家自然科学基金面上基金 酸敏感离子通道(ASICs)：小胶质细胞炎症免疫反应的重要调节蛋白（No. 81173071）；主持（已结题）

3. 国家自然科学基金面上基金 小胶质细胞特有质子通道Hv1调节氧化应激在可卡因成瘾中的作用及机制研究（No. 81473199）；主持

4. 湖北省科技研究与开发计划项目 作用于多靶点神经保护药物的合作研发（2011BFA006）；主持（已结题）

5. 华中科技大学自主创新研究基金（重点专项项目） 治疗抑郁症新靶点：酸敏感离子通道；2013.7-2014.6；8万；主持（已结题）

6. 华中科技大学自主创新研究基金前沿探索基金 GABA 能神经调控中脑多巴胺能神经元活动在抑郁症发生中的作用；2015.1-2016.12；6万；主持（已结题）

7. 国家重点基础研究发展计划 潜在抑郁风险评估相关的生物信息；2014.1-2018.8；73万；参与（排名第二）

8. 湖北省科技厅群体项目 抑郁症发病机制及干预策略研究创新群体；2015.1-2017.12；参与（排名第三）

代表性论文：

通讯作者文章:

①. Ming Ni#, Jin-Gang He#, Hai-Yun Zhou, Xiao-Jia Lu, Yuan-Lang Hu, Li Mao, Fang Wang, Jian-Guo Chen, Zhuang-Li Hu*. Pannexin-1 channel dysfunction in the medial prefrontal cortex mediates depressive-like behaviors induced by chronic social defeat stress and administration of mefloquine in mice. Neuropharmacology, 2017 Dec 5.

②. Yuan-Lang Hu#，Xue Mi#，Chao Huang，Hui-Fang Wang，Jian-Ren Song，Qing Shu，Lan Ni，Jian-Guo Chen，Fang Wang，Zhuang-Li Hu*. Multiple H⁺ sensors mediate the extracellular acidification-induced [Ca²⁺]i elevation in cultured rat ventricular cardiomyocytes. Sci Rep.2017 Mar 23; 7: 44951.

③. Hui Fu#, Peng Fang#, Hai-Yun Zhou, Jun Zhou, Xiao-Wei Yu, Ming Ni, Jie-Yan Zheng, You Jin, Jian-Guo Chen, Fang Wang and Zhuang-Li Hu*. Acid-sensing ion channels in trigeminal ganglion neurons innervating the orofacial region contribute to orofacial inflammatory pain. Clin Exp Pharmacol Physiol. 2016 Feb; 43(2):193-202.

④. Rui-Li Liu, Qiu-Ju Xiong, Qing Shu, Wen-Ning Wu, Jin Cheng, Hui Fu, Fang Wang, Jian-Guo Chen, Zhuang-Li Hu*. Hyperoside protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via nitric oxide signal pathway. Brain Res. 2012 Aug 21; 1469:164-73.

第一作者文章：

①. Xiao-Yi Hou, Zhuang-Li Hu(并列第一作者), Deng-Zheng Zhang, Wei Lu, Jun Zhou, Pei-Fei Wu, Xin-Lei Guan, Qian-Qian Han, Si-Long Deng, Hai Zhang, Jian-Guo Chen* and Fang Wang*. Rapid Antidepressant Effect of Hydrogen Sulfide: Evidence for Activation of mTORC1-TrkB-AMPA Receptor Pathways. Antioxid Redox Signal. 2017 Feb 3.

②. Yun Ling, Zhuangli Hu(并列第一作者), Qingli Meng, Peng Fang, Haixia Liu*. Bimatoprost Increases Mechanosensitivity of Trigeminal Ganglion Neurons Innervating the Inner Walls of Rat Anterior Chambers via Activation of TRPA1. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):567-76.

③. Xiao-Wei Yu, Zhuang-Li Hu(并列第一作者), Ming Ni, Peng Fang, Pei-Wei Zhang, Qing Shu, Hua Fan, Hai-Yun Zhou, Lan Ni, Ling-Qiang Zhu, Jian-Guo Chen* and Fang Wang*. Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia. Glia. 2015 Mar; 63(3):483-96.

④. Qing Shu, Zhuang-Li Hu(并列第一作者), Chao Huang, Xiao-Wei Yu, Hua Fan, Jing-Wen Yang, Peng Fang, Lan Ni, Jian-Guo Chen, Fang Wang*. Orexin-A Promotes Cell Migration in Cultured Rat Astrocytes via Ca2+-Dependent PKCα and ERK1/2 Signals. PLoS One. 2014 Apr 18; 9(4): e95259.

⑤. Qiu-Ju Xiong, Zhuang-Li Hu(并列第一作者), Peng-Fei Wu, Lan Ni, Zhi-Fang Deng, Wen-Ning Wu, Jian-Guo Chen, Fang Wang*. Acid-sensing ion channels contribute to the increase in vesicular release from SH-SY5Y cells stimulated by extracellular protons. Am J Physiol Cell Physiol. 2012 Aug; 303(4):C376-84.

⑥. Zhuang-Li Hu, Chao Huang, Hui Fu, You Jin, Wen-Ning Wu, Qiu-Ju Xiong, Na Xie, Li-Hong Long, Jian-Guo Chen and Fang Wang*. PICK1 disruption attenuates both functions of ASICs and regulations of PKC on ASICs. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1355-62.

⑦. Chao Huang, Zhuang-Li Hu(并列第一作者), Wen-ning Wu, Dan-Fang Yu, Qiu-Ju Xiong, Jian-Ren Song, Qing Shu, Hui Fu, Fang Wang* and Jian-Guo Chen*. Existence and distinction of acid-evoked currents in rat astrocytes. Glia. 2010 Sep;58(12):1415-24.

⑧. Zhuangli Hu, Juan Chen, Qin Wei, and Yong Xia*. Bidirectional Actions of Hydrogen Peroxide on Endothelial Nitric Oxide Synthase Phosphorylation and Function: co-commitment and interplay of Akt and AMPK. J. Biol. Chem. 2008 Sep 12; 283(37): 25256-25263.

重要参与作者文章：

①. M-X Li, H-L Zheng, Y Luo, J-G He, W Wang, J Han, L Zhang, X Wang, L Ni1, H-Y Zhou, Z-L Hu, P-F Wu, Y Jin, L-H Long, H Zhang, G Hu, J-G Chen* and F Wang*. Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs. Molecular Psychiatry, 2018, 23: 556–568

②. Fan Hua, Wu Peng-Fei, Zhang Ling, Hu Zhuang-Li, Wang Wen, Guan Xin-Lei, Luo Han, Ni Ming, Yang Jing-Wen, Li Ming-Xing, Chen Jian-Guo* and Wang Fang*. Methionine sulfoxide reductase A negatively controls microglia-mediated neuroinflammation via inhibiting ROS/MAPKs/NF-κB signaling pathways through a catalytic antioxidant function. Antioxid Redox Signal. 2015 Apr 1;22(10):832-47.

③. Yi Luo, Jun Zhou, Ming-Xing Li, Peng-Fei Wu, Zhuang-Li Hu, Lan Ni, You Jin, Jian-Guo Chen* and Fang Wang*. Reversal of aging-related emotional memory deficits by norepinephrine via regulating the stability of surface AMPA receptors. Aging Cell. 2015 Apr;14(2):170-9.

④. Hai-Feng Lu, Peng-Fei Wu, Yuan-Jian Yang, Wen Xiao, Jun Fan, Jing Liu, Yuan-Long Li, Yi Luo, Zhuangli Hu, You Jin, Fang Wang*, Jian-Guo Chen*. Interactions between N-ethylmaleimide-sensitive factor and GluR2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine. J Neurosci. 2014 Mar 5; 34(10):3493-508.

⑤. Bo Jiang, Wei Wang, Fang Wang, Zhuang-Li Hu, Jun-Li Xiao, Si Yang, Jing Zhang, Xiao-Zhong Peng, Jin-Hui Wang, Jian-Guo Chen*. The Stability of NR2B in the Nucleus Accumbens Controls Behavioral and Synaptic Adaptations to Chronic Stress. Biol Psychiatry. 2013 Jul 15; 74(2):145-155.

⑥. Yan-Kun Li, Fang Wang, Wei Wang, Yi Luo, Peng-Fei Wu, Jun-Li Xiao, Zhuang-Li Hu, You Jin, Gang Hu and Jian-Guo Chen*. Aquaporin-4 Deficiency Impairs Synaptic Plasticity and Associative Fear Memory in the Lateral Amygdala: Involvement of Downregulation of Glutamate Transporter-1 Expression. Neuropsychopharmacology. 2012 Jul; 37(8):1867-78.

⑦. Bo Jiang, Zhe Xiong, Jun Yang, Wei Wang, Yue Wang, Zhuang-Li Hu, Fang Wang*, Jian-Guo Chen*. Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus. Br J Pharmacol.2012 Jul;166(6):1872-87.

⑧. Wang W, Wang F, Yang YJ, Hu ZL, Long LH, Fu H, Xie N, Chen JG*. The flavonoid baicalein promotes NMDA receptor-dependent long-term potentiation and enhances memory. Br J Pharmacol. 2011 Mar; 162(6):1364-79.

⑨. Yang YJ, Wu PF, Long LH, Yu DF, Wu WN, Hu ZL, Fu H, Xie N, Jin Y, Ni L, Wang JZ, Wang F*, Chen JG*. Reversal of Aging-Associated Hippocampal Synaptic Plasticity Deficits by Reductants via Regulation of Thiol Redox and NMDA Receptor Function. Aging Cell. 2010 Oct; 9(5):709-21.