何金钢，男，博士，副教授。现为中国药理学会神经精神药理学会青年专业委员会委员。2012年本科毕业于华中科技大学同济医学院临床医学（五年制）专业，获医学学士学位。2018年毕业于华中科技大学同济医学院基础医学院药理学专业，获医学博士学位。2018至2021年，在同济医学院基础医学院进行博士后研究。主要从事抑郁症发病机制以及相关药物靶点研究。以第一、共同第一作者在Nature Communications、Biological Psychiatry、Neuropharmacology等杂志发表论文多篇。作为负责人主持国家自然科学基金2项，中国博士后科学基金面上项目以及特别资助项目各1项。获华夏医学科技进步奖（5/10）、湖北省优秀科技论文奖、华中科技大学教师教学竞赛二等奖、湖北省/武汉药理学会教学竞赛一等奖等奖励。

研究方向：情感障碍性疾病（抑郁症、焦虑症）发病机制以及相关药物靶点研究

联系方式：QQ：573999939   E-mail：hejg@hust.edu.cn

主要研究项目：

1. 国家自然科学基金面上基金项目，82273911，骨-脑轴介导的lipocalin2/MC4R通路异常在围绝经期抑郁症中的机制研究，主持

2. 国家自然科学基金青年科学基金项目，81903594，肿瘤细胞外泌体Twist1在癌症诱导的抑郁症中的作用及机制研究，主持

3. 中国博士后科学基金特别资助，2020T130226，更年期骨质疏松介导的lipocalin-2-MC4R信号通路异常在抑郁症中的作用及机制研究，主持

4. 中国博士后科学基金面上资助，2018M642854，Twist1在癌症诱发的小鼠抑郁样行为中的作用及机制研究，主持

5. 华中科技大学技术创新基金，伏隔核区NMDA受体依赖的突触可塑性对抑郁样行为的影响及机制，主持

代表性学术论文:

(1) Kai-Yu Zheng^(#), Bo Gao^(#), Hua-Jie Wang, Jin-Gang He, Hong-Sheng Chen, Zhuang-Li Hu, Li-Hong Long, Jian-Guo Chen^(*), Fang Wang^(*). Melatonin Ameliorates Depressive-Like Behaviors in Ovariectomized Mice by Improving Tryptophan Metabolism via Inhibition of Gut Microbe Alistipes Inops. Adv Sci (Weinh). 2024 Sep;11(34):e2309473.

(2) Shi-Ge Xue^(#), Jin-Gang He^(#), Ling-Li Lu, Shi-Jie Song, Mei-Mei Chen, Fang Wang^(*), Jian-Guo Chen^(*). Enhanced TARP-γ8-PSD-95 coupling in excitatory neurons contributes to the rapid antidepressant-like action of ketamine in male mice. Nat Communications. 2023 Dec 2;14(1):7971.

(3) Shao-Qi Zhang^(#), Qiao Deng^(#), Qi Zhu^(#), Zhuang-Li Hu, Li-Hong Long, Peng-Fei Wu, Jin-Gang He, Hong-Sheng Chen, Zhenyu Yue, Jia-Hong Lu^(*), Fang Wang^(*), Jian-Guo Chen^(*). Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression. Cell Discovery. 2023 Aug 29;9(1):90.

(4) Jia-Jing Lu^(#); Peng-Fei Wu^(#); Jin-Gang He; Yu-Ke Li; Li-Hong Long; Xia-Ping Yao; Jia-Hao Yang; Hong-Sheng Chen; Xiang-Nan Zhang; Zhuang-Li Hu; Zhong Chen; Wang Fang^(*); Chen Jianguo^(*). BNIP3L/NIX-mediated mitophagy alleviates passive stress-coping behaviors induced by tumor necrosis factor-α. Molecular Psychiatry, 2023 Mar 13. doi: 10.1038/s41380-023-02008-z

(5) Jin-Gang He; Hai-Yun Zhou; Fang Wang, Jian-Guo Chen. Dysfunction of Glutamatergic Synaptic Transmission in Depression: Focus on AMPA Receptor Trafficking. Biol Psychiatry Glob Open Sci. 2022 Mar 8;3(2):187-196.

(6) Jin-Gang He; Hai-Yun Zhou; Shi-Ge Xue; Jia-Jing Lu; Jun-Feng Xu; Bin Zhou; Zhuang-Li Hu; Peng-Fei Wu; Li-Hong Long; Lan Ni; You Jin; Fang Wang^(*); Jian-Guo Chen^(*). Transcription Factor TWIST1 Integrates Dendritic Remodeling and Chronic Stress to Promote Depressive-like Behaviors. Biol Psychiatry. 2021 Mar 15;89(6):615-626.

(7) Zhou Haiyun^(#); He Jingang^(#); Hu Zhuangli^(#); Xue Shige; Xu Junfeng; Cui Qianqian; Gao Shuangqi; Zhou Bin; Wu Pengfei; Long Lihong; Wang Fang^(*); Chen Jianguo^(*). A-Kinase Anchoring Protein 150-Protein Kinase A Complex in the Basolateral Amygdala Contributes to Depressive-like Behaviors Induced by Chronic Restraint Stress. Biological Psychiatry, 2019 Jul 15; 86(2): 131-142.

(8) Li Mingxing^(#); Zheng Huiling; Luo Yi; He jingang; Wang Wen; Han Jun; Zhang ling; Wang Xiao; Ni Lan; Zhou Haiyun; Wu Pengfei; Jin You; Long Lihong; Zhang Hai; Hu Gang; Chen Jianguo^(*); Wang Fang^(*). Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs. Molecular psychiatry, 2018, 23(3): 556-568.

(9) Ni Ming^(#); He Jingang^(#); Zhou Haiyun; Lu Xiaojia; Hu Yuanlang; Mao Li; Wang Fang; Chen Jianguo; Hu Zhuangli^(*). Pannexin-1 channel dysfunction in the medial prefrontal cortex mediates depressive-like behaviors induced by chronic social defeat stress and administration of mefloquine in mice. Neuropharmacology, 2018, 137: 256-267.