联系方式：武汉市汉口航空路13#，华中科技大学同济医学院基础2号楼1125室，华中科技大学脑研究所，华中科技大学神经生物学系

工作背景：

2015.03-至今   副教授，华中科技大学同济医学院，基础医学院神经生物学系；

2019.09-2021.09 高级访问学者，美国华盛顿大学医学院，疼痛中心与麻醉学系；

2016.12-2017.12挂职，科技部中国生物技术发展中心，医药处

2011.08-2015.03 博士后，华中科技大学基础医学博士后流动站，合作导师为鲁友明教授；

2009.09-2010.12 访问科学家，荷兰神经科学研究所（NIN）/阿姆斯特丹大学医学中心(AMC)，研究方向为下丘脑参与外周能量代谢调控的神经机制，合作导师为著名的神经科学家Dick Swaab教授与Andries Kalsbeek教授。

教育背景：

2007.09-2011.06 博士学位，华中科技大学同济医学院神经生物学系攻读细胞与分子神经生物学专业博士，研究方向为疼痛的细胞与分子神经生物学机制，导师为施静教授；

2004.09-2007.07 硕士学位,华中科技大学同济医学院攻读神经生物学系硕

士，研究方向为炎症性疼痛的细胞与分子机制；

1998.09-2003.07 医学学士学位，咸宁医学院攻读临床医学系本科；

(1) Ke, X, Deng, MF, Wu, Z, Yu, H, Yu, D, Li, H, Lu, Y, Shu, K, Pei, L*. miR‑34b‑3p Inhibition of eIF4E Causes Post‑stroke Depression in Adult Mice. Neurosci. Bull. 2022 July 8 (Online); https://doi.org/10.1007/s12264-022-00898-7. (Co-corresponding author)

(2) Zhang, YF, Ma, SH, Ke, X, Yi, Y, Yu, HY, Yu, D, Li, Q, Shang, Y, Lu, YM, Pei, L*. The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons. Cell Biosci. 2021 Aug 26;11(1):167. (corresponding author)

(3) Su, TF, Yan, Y, Li, Q, Ye, JC*, Pei, L*. Endocannabinoid System Unlocks the Puzzle of Autism Treatment via Microglia. Front Psychiatry. 2021 Oct 22;12:734837. (Co-corresponding author)

(4) Su, TF, Pei, L*. Acupuncture and oxytocinergic system: The promising treatment for autism. Transl Neurosci. 2021 Feb 16;12(1):96-102. (corresponding author)

(5) Ma, XY, Xiao, WC, Li, H, Pang, P, Xue, FX, Wan, L, Pei, L*, Yan, HH*.Metformin restores hippocampal neurogenesis and learning and memory via regulating gut microbiota in the obese mouse model. Brain Behav Immun. 2021 Jul;95:68-83. (Co-corresponding author)

(6) Wang S, Chen D, Yu J, Wang X, Li Q, Lv F, Shen H, Pei L*. Presynaptic Caytaxin prevents apoptosis via deactivating DAPK1 in the acute phase of cerebral ischemic stroke. Exp Neurol. 2020 Jul;329:113303. (corresponding author)

(7)Cai Y, Zhang Y, Ke X, Guo Y, Yao C, Tang N, Pang P, Xie G, Fang L, Zhang Z, Li J, Fan Y, He X, Wen R, Pei L*, Lu Y*. Transcriptome Sequencing Unravels Potential Biomarkers at Different Stages of Cerebral Ischemic Stroke. Front Genet. 2019 Sep 24;10:814. doi: 10.3389/fgene.2019.00814. (corresponding author)

(8)Guo Y, Li H, Ke X, Deng M, Wu Z, Cai Y, Afewerky HK, Zhang X, Pei L*, Lu Y*. Degradation of Caytaxin Causes Learning and Memory Deficits via Activation of DAPK1 in Aging. Mol Neurobiol. 2019 May;56(5):3368-3379.(corresponding author)

(9)Li SJ, Zhang YF, Ma SH, Yi Y, Yu HY, Pei L*, Feng D*. The role of NLRP3 inflammasome in stroke and central poststroke pain. Medicine (Baltimore). 2018 Aug;97(33):e11861.(corresponding author)

(10)Xiong W, Wu Y, Xian W, Song L, Hu L, Pan S, Liu M, Yao S, Pei L*, Shang Y*. DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells. J Neurol Sci. 2018 Apr 15;387:210-219. (corresponding author)

(11)Song L*, Pei L*, Hu L, Pan S, Xiong W, Liu M, Wu Y, Shang Y, Yao S. Death-associated protein kinase 1 mediates interleukin-1β production through regulating inlfammasome activation in Bv2 microglial cells and mice. Sci Rep. 2018 Jul 2;8(1):9930.

(12)Chen LM, Zhu MX, Zhang YF, Ma SH, Yi Y, Xia LX, Wu Y, Pei L*. A 58-Year

Old Male with Cognitive Deteriorations Caused by Septum Pellucidum Cyst: A Case Report. Front Aging Neurosci. 2017 Sep 13;9:299. doi: 10.3389/fnagi.2017.00299. eCollection 2017. (corresponding author)

(13)Jin HJ*, Pei L*, Li YN*, Zheng H, et al. Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression.Sci Rep.2017Nov2;7(1):14926. doi: 10.1038/s41598-017-13929-5.

(14)Song L*, Pei L*, Yao S, Wu Y, Shang Y. NLRP3 Inflammasome in Neurological  

Diseases, from Functions to Therapies. Front Cell Neurosci. 2017 Mar 9;11:63. (Co-first author)

(15) Tang N, Wu J, Zhu H, Yan H, Guo Y, Cai Y, Yan H, Shi Y, Shu S, Pei L*, Lu Y*. Genetic Mutation of GluN2B Protects Brain Cells Against Stroke Damages. Mol Neurobiol. 2017 Apr 29. doi: 10.1007/s12035-017-0562-y. (corresponding author).

(16)Lei Pei, Shan Wang, Jin Huijuan, et al. A Novel Mechanism of Spine Damages in stroke via DAPK1 and Tau. Cereb Cortex. 2015 Nov;25(11):4559-71.

(17)H Jin*, L Pei*, X Shu*, X Yang, T Yan, Y Wu, Na Wei, Honglin Yan, Shan Wang, Chengye Yao, Dan Liu, Qing Tian, Lin Wang, Youming Lu. Therapeutic Intervention of Learning and Memory Decays by Salidroside Stimulation of Neurogenesis in Aging. Molecular Neurobiology, 2016 Mar;53(2):851-66. (Co-first author)

(18)Xiaoxi Wang*, Lei Pei*, Honglin Yan*, Zhongping Wang, Na Wei, Shan Wang, Xin Yang, Qing Tian, and Youming Lu. Intervention of DAPK1-p53 Interaction Exerts the Therapeutic Effects against Stroke. Stroke, 2014 Oct;45(10):3089-91 (Co-first author)

(19)Lei Pei, You Shang, Huijuan Jin, Shan Wang, Na Wei, Honglin Yan, Yan Wu,  

Chengye Yao, Xiaoxi Wang, Ling-Qiang Zhu, and Youming Lu. DAPK1-p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death. The Journal of Neuroscience, 2014, 34(19):6546–6556.

(20)Lizhao Wang, Dan Feng, Huanhuan Yan, Zhongping Wang, Lei Pei*. The Comparative Analysis of P2X1, P2X2, P2X3 AND P2X4 Receptor Subunits in Rat Nodose Ganglion Neurons. PLoS ONE 9(05): e96699, doi:10.1371/journal.pone.0096699 (corresponding author).

(21)L Chen, F Lv, L Pei*. Annexin 1: a glucocorticoid-inducible protein that modulates inflammatory pain. European Journal of Pain, 18 (2014) 338–347 (corresponding author).

(22)L Chen, M Jiang, L Pei*. Comparison of Three Method s of Drug Delivery in the

Rat Lumbar Spinal Subarachnoid Space. THE ANATOMICAL RECORD 2012, 295:1212–1220 (corresponding author).

(23)L Pei, J Zhang, F Zhao, T Su, H Wei, J Tian, M Li, J Shi. Annexin 1 exerts anti-nociceptive effects through formyl-peptide-receptor-like 1 in rat dorsal root ganglion after peripheral inflammatory pain. British Journal of Anaesthesia 2011, 107(6): 948-958.

(24)L Pei, C Lin, J Dai, G Yin. Facial pain induces the alteration of transient receptor potential vanilloid receptor 1 expression in rat trigeminal ganglion, Neuroscience Bulletin 2007, 23(2): 92-100.

Co-author Publications

(1)Li X, Chen W, Pan K, Li H, Pang P, Guo Y, Shu S, Cai Y, Pei L, Liu D, Afewerky HK, Tian Q, Zhu LQ, Lu Y. Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger-Westphal nucleus. Nat Neurosci. 2018 Sep;21(9):1239-1250.

(2)Tuo QZ, Liuyang ZY, Pei L, Yan X, Shentu YP, Liang JW, Zhou H, Pei L, Xiong Y, Hou TY, Zhou XW, Wang Q, Wang JZ, Wang XC, Liu R. Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke. Cell Death Dis. 2018 Aug 29;9(9):870.

(3)Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ, Lu Y. Synaptic mechanism in Alzheimer’s disease: a selective degeneration of an excitatory synaptic pathway in the CA1 hippocampus that controls spatial learning and memory in Alzheimer’s disease. Mol Psychiatry. 2018 Feb;23(2):167.

(4)Zhu H, Yan H, Tang N, Li X, Pang P, Li H, Chen W, Guo Y, Shu S, Cai Y, Pei L, Liu D, Luo MH, Man H, Tian Q, Mu Y, Zhu LQ, Lu Y. Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun. 2017 Nov 22;8(1):1676. doi: 10.1038/s41467-017-01943-0.

(5)Bi LL, Chen M, Pei L, Shu S, Jin HJ, Yan HL, Wei N, Wang S, Yang X, Yan HH, Xu MM, Yao CY, Li N, Tang N, Wu JH, Zhu HZ, Li H, Cai Y, Guo Y, Shi Y, Tian Q, Zhu LQ, Lu YM.Infralimbic Endothelin1 Is Critical for the Modulation of Anxiety-Like Behaviors. Mol Neurobiol. 2016 Apr;53(3):2054-2064.

(6)Zhang T, Pang P, Fang Z, Guo Y, Li H, Li X, Tian T, Yang X, Chen W, Shu S, Tang N, Wu J, Zhu H, Pei L, Liu D, Tian Q, Wang J, Wang L, Zhu LQ, Lu Y. Expression of BC1 Impairs Spatial Learning and Memory in Alzheimer's Disease Via APP Translation. Mol Neurobiol. 2017 Nov 13. doi: 10.1007/s12035-017-0820-z.

(7)Wang S, Shi X, Li H, Pang P, Pei L, Shen H, Lu Y. DAPK1 Signaling Pathways in Stroke: from Mechanisms to Therapies. Mol Neurobiol. 2017 Aug;54(6):4716-4722.

(8) Yan H, Pang P, Chen W, Zhu H, Henok K A, Li H, Wu Z, Ke X, Wu J, Zhang T, Pan K, Pei L, Han Y, Lu Y. The Lesion Analysis of Cholinergic Neurons in 5XFAD Mouse Model in the Three-Dimensional Level of Whole Brain. Mol Neurobiol. 2017 Jul 7. doi: 10.1007/s12035-017-0672-6.

(9) Shu S, Zhu H, Tang N, Chen W, Li X, Li H, Pei L, Liu D, Mu Y, Tian Q, Zhu LQ, Lu Y. Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's Disease via Activation of DAPK1. J Neurosci. 2016 Oct 19;36(42):10843-10852.

(10) Xian W, Wu Y, Xiong W, Li L, Li T, Pan S, Song L, Hu L, Pei L, Yao S, Shang Y. The pro-resolving lipid mediator Maresin 1 protects against cerebral ischemia/reperfusion injury by attenuating the pro-inflammatory response. Biochem Biophys Res Commun. 2016 Mar 25;472(1):175-81.

(11) Li L, Wu Y, Wang Y, Wu J, Song L, Xian W, Yuan S, Pei L, Shang Y. Resolvin D1 promotes the interleukin-4-induced alternative activation in BV-2 microglial cells. J Neuroinflammation. 2014 Apr 5;11:72. doi: 10.1186/1742-2094-11-72.

(12)K Zhao, R Wen, X Wang, Pei L, Y Yang, Y Shang, N Bazan, L Zhu, Q Tian, and Y Lu. EPAC Inhibition of SUR1 Receptor Increases Glutamate Release and Seizure Vulnerability. The Journal of Neuroscience, 2013, 33(20): 8861-8865.

(13)Y Yang, X Shu, D Liu, Y Shang, Y Wu, Pei L, X Xu, Q Tian, K Qian, Y Wang, R S. Petralia, W Tu, L Zhu, J Wang, Y Lu. EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation, Neuron 2012, 73(4):774-778.

(14)E Bruinstroop, Pei L, M T Ackermans, E Foppen, A J Borgers, J Kwakkel, A Alkemade, E Fliers, A Kalsbeek. Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL-triglyceride secretion in rats via the sympathetic nervous system, Diabetes 2012, 61(5):1043-1050.

(15) A Alkemade, C Yi, Pei L, M Harakalova, D F Swaab, S E la Fleur, E Fliers, A Kalsbeek. AgRP and NPY expression in the human hypothalamic infundibular nucleus correlate with body mass index, whereas changes in MSH are related to type 2 diabetes, The Journal of Clinical Endocrinology & Metabolism 2012, 97(6):E925-33.

(16) J Zhang, F Zhao, Y Zhao, J Wang, L Pei, N Sun, J Shi. Hypoxia induces an increase in intracellular magnesium via TRPM7 channels in rat hippocampal neurons in vitro, The Journal of biological chemistry 2011, 286(23):0194-20207.

(17) TF Su, YQ Zhao, LH Zhang, M Peng, CH Wu, L Pei, B Tian, J Zhang, J Shi, HL Pan, M Li Electroacupuncture Reduces the Expression of Proinflammatory Cytokines in Inflamed Skin Tissues through Activation of Cannabinoid CB2 Receptors, European journal of pain 2011, 7(1): 98.

(18) J Zhang, L Chen, T Su, F Cao, X Meng, L Pei, J Shi, HL Pan, M Li. Electroacupuncture increases CB2 receptor expression on keratinocytes and infiltrating inflammatory cells in inflamed skin tissues of rats, The Journal of Pain 2010, 11(12), 1250-1258.

(19) W Fu, J Chen, Y Cai, Y Lei, L Chen, L Pei, D Zhou, X Liang, J Ruan. Antioxidant, free radical scavenging, anti-inflammatory and hepatoprotective potential of the extract from Parathelypteris nipponica Ching, Journal of Ethnopharmacology 2010, 130 (3): 521-528.

(20) H Liu, Z Li, M Yang, X Tian, L Pei, C Li. Sensory innervation of the anterior eye segment in rats: a retrograde tracing study. FRONTIERS OF MEDICINE IN CHINA 2009, 3 (3): 352-356.

(21) Jiang Q, Wang L, Guan Y, Xu H, Niu Y, Han L, Wei YP, Lin L, Chu J, Wang Q, Yang Y, L Pei, Wang JZ, Tian Q. Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase. Neurobiol Aging. 2014 Jun;35(6):1352-63.

专利

(1) 张玉芬; 马瑟惠; 柯霄; 余鸿雁; 余点; 尚游; 裴磊; 鲁友明 ; 一种大鼠脑内自由给药及采血装置,2020-05-15, 中国, ZL 2019 2 0852792.3

(2)旺姗,裴磊,颜欢欢,郭豫,李浩,唐娜,庞培,鲁友明; 一种小分子多肽、其应用及产品. 2015.04.08, CN201410734580.7

(3)李熳,潘晓莉,王俊俊,刘双喜,张力,宋元龙,郭乐江,裴磊. 一种临床用肌电测痛装置，2015.7.1，中国，ZL 2014 2 0865547.3；

(4)鲁友明,裴磊,朱铃强,徐传瑞. 小分子多肽TAT-p53DM及其在制备治疗或预防缺血性卒中药物中的应用,2015.10.28,中国，ZL 2014 1 0141844.8;

(5)裴磊, 施静. 简易热机械两用测痛仪（ZL 2009 20154972.0 CN201533832U）

主持科研项目

（1）华中科技大学自主创新研究基金项目《缺血性卒中后DAPK1通过Caytaxin介导突触前损伤的机制研究》（5万元）（已结题）

（2）中荷合作项目《下丘脑参与外周能量代谢调控的神经机制（09CDP022）研究》（1.95万欧元）（已结题）

（4）中国博士后科学基金面上项目一等资助（Annexin1-FPR2/ALX通路抑制TRPV1作用机制研究）（2013M530345）(8万元) （已结题）

（5）中国博士后科学基金面上项目一等资助（DAPK1-Tau相互作用介导突触损伤的机制研究） （2013M540583）(8万元) （已结题）

（6）国家自然科学基金青年研究项目<Annexin1 调节瞬时感受器电位香草素受体1 敏感性介导抗炎症痛的机制研究>（81200863）（23万元）（已结题）

（7）国家自然科学基金面上研究项目<死亡相关蛋白激酶1介导皮层丘脑环路损伤引起卒中后疼痛的机制研究>（81571078）（57万元）

（8）国家自然科学基金面上研究项目<死亡相关蛋白激酶1损伤海马前额叶皮层环路介导卒中后抑郁的机制研究>（81870932）（56万元）

参与学术活动 （会议）

(1) 中英学术大讲堂（一）

(2) 2020科学编辑理事会年会 （2020 CSE Virtual Annual Meeting (CSE2020)），美国圣路易斯华盛顿大学医学院（WUSTL），2020年5月4日，How to survive and thrive in the research environment and system in China: an experience of a medical scientist.口头报告。

(3)第38届日本神经科学年会 (the 38th Annual Meeting of the Japanese Neuroscience Society)，日本神户国际会议中心，2015年 7月28-31日，Cerebrovascular Disease and Ischemia Session, 2007-2-3(17:00),口头报告。

获奖情况：

2014年 IBRO国际脑研究组织 Travel Grant

2015年 德国神经科学学会GNS Travel Grant (Stipend for the 11th Göttingen Meeting of the German Neuroscience Society 2015)

2015年 第38届日本神经科学年会Travel Awards (Travel Awards for the 38th Annual Meeting of the JNS)

2015年 中国神经科学学会赛诺菲优秀会议论文奖

2016年 湖北省科学协会第16届自然科学优秀论文一等奖