吕义晟教授

华中科技大学教授、博士生导师。

2007年在清华大学理学生物系获得博士学位，主要研究学习记忆的分子机理及老年痴呆症的发病机理。2008年赴美国Medical College of Georgia 进行博士后研究，在美期间主要从事精神分裂症的致病机理,以及神经肌肉接头发育以及相关疾病机理的研究，并在Neuron、Journal of Neuroscience、Journal of Clinical Investigation、Development、PNAS、Faseb J.等国际学术刊物上发表多篇学术论文。2015年5月回国工作，受聘为华中科技大学基础医学院生理学系教授。

联系方式：

基础医学院2号楼16楼1618

电话：027-83692622

Email：luys@hust.edu.cn

1.讲授的本科生课程

课程名称	课程类别	周学时	学生届数	学生总人数
生理学（全英文）	专业基础课	8	3届	约150人
生理学	专业基础课	8	10届	约150人

2.承担的本科实践性教学任务

实践教学任务	总学时	班级	学生总人数
机能实验I	160*10	五年制各专业，八年制及中德实验班	约300人

3.讲授的研究生课程

课程名称	课程类别	周学时	学生届数	学生总人数
医学生理学	公选课(核心通识）	4	10届	约100人

4.近五年来承担的学术研究课题：

(1) 国家自然科学基金面上项目：敲除多巴胺及其受体D2阳性神经元ErbB4引起精神分裂症表型的机制，起止年月：2017-01至2020-12，金额：60万元

(2) 国家自然科学基金面上项目：GM527蛋白通过影响多巴胺受体引起精神分裂症相关表型的机理，起止年月：2021-01至2024-12，金额：55万元

5.在国内外公开发行刊物上发表的学术论文：

[1]Zhanghong Zhou, E Tian 1, Jun Wang, Zhaoqi Guo, Jingyu Chen, Jiaqi Guo, Shiyu Shi, Wandi Xu, Xixi Yu, Caijuan Qiao, Yuejin Zhang, Yisheng Lu*, Sulin Zhang*, Cognitive impairments and neurobiological changes induced by unilateral vestibular dysfunction in mice, Neurobiol Dis. 2024 Oct 30:202:106719. doi: 10.1016/j.nbd.2024.106719. (* corresponding author)

[2]Jun Wang, Dan Liu, E Tian, Yuejin Zhang, Zhaoqi Guo, Jingyu Chen, Jiaqi Guo, Zhanghong Zhou, Shiyu Shi, Yisheng Lu*, Sulin Zhang*, Molecular profile of vestibular compensation in the medial vestibular nucleus after unilateral labyrinthectomy, J Cell Mol Med.,2024 Jul;28(14): e18532. doi: 10.1111/jcmm.18532. (* corresponding author)

[3]Zhaoqi Guo, E Tian, Sen Chen, Jun Wang, Jingyu Chen, Weijia Kong, Debbie C Crans*, Yisheng Lu*, Sulin Zhang*, Lercanidipine’s Antioxidative Effect Prevents Noise-Induced Hearing Loss, Antioxidants (Basel). 2024 Mar 7;13(3):327. doi: 10.3390/antiox13030327(* corresponding author)

[4]Yandong Yi, Yuejin Zhang, Yuanlong Song, Yisheng Lu*, Treadmill Running Regulates Adult Neurogenesis, Spatial and Non-spatial Learning, Parvalbumin Neuron Activity by ErbB4 Signaling, Cell Mol Neurobiol, 2024 Jan 29;44(1):17.Doi: 10.1007/s10571-023-01439-0. (* corresponding author)

[5]Yuejin Zhang, Guangpin Chu, Yangming Leng, Xueling Lin, Hong Zhou, Yisheng Lu*, Bo Liu*, Parvalbumin-positive neurons in the medial vestibular nucleus contribute to vestibular compensation through commissural inhibition, Front Cell Neurosci., 2023, 8:17:1260243. Doi: 10.3389/fncel.2023.1260243. eCollection 2023. (* corresponding author)

[6]Jun Wang, E Tian, Yuejin Zhang, Zhaoqi Guo, Jingyu Chen, Weijia Kong, Yisheng Lu*, Sulin Zhang*, The Effects of Unilateral Labyrinthectomy on Monoamine Neurotransmitters in the Medial Vestibular Nucleus of Rats, Biomolecules, 2023, 10;13(11):1637. Doi: 10.3390/biom13111637 (* corresponding author)

[7]Xueling Lin, Xiuping Wang, Yuejin Zhang, Guangpin Chu, Jingwen Liang, Bin Zhang, Yisheng Lu*, Oswald Steward*, Juan Luo*, Synergistic effect of chemogenetic activation of corticospinal motoneurons and physical exercise in promoting functional recovery after spinal cord injury, Experimental Neurology, 2023, 370: 114549. Doi: 10.1016/j.expneurol.2023.114549 (* corresponding author)

[8]Dan Liu, Jun Wang, E Tian, Jingyu Chen, Weijia Kong, Yisheng Lu*, Sulin Zhang*, mGluR1/IP3/ERK signaling pathway regulates vestibular compensation in ON UBCs of the cerebellar flocculus, CNS Neuroscience & Therapeutics, 2023, Doi: 10.1111/cns.14419 (* corresponding author)

[9]Jie Jia, Hualing Peng, Rui Tian, Hong Zhou, Hua Zheng*, Bo Liu*, Yisheng Lu*, Gm527 deficiency in dentate gyrus improves memory through upregulating dopamine D1 receptor pathway, CNS Neuroscience & Therapeutics, 2023, 29(11): 3290–3306, Doi: 10.1111/cns.14259 (* corresponding author)

[10]Dan Liu, Jun Wang, Liuqing Zhou, E Tian, Jingyu Chen, Weijia Kong, Yisheng Lu*, Sulin Zhang*, Differential Modulation of Cerebellar Flocculus Unipolar Brush Cells during Vestibular Compensation, Biomedicines, 2023, 11(5): 1298. Doi: 10.3390/biomedicines11051298. (* corresponding author)

[11]Nana Yu, Huina Song, Guangpin Chu, Xu Zhan, Bo Liu, Yangling Mu, Jian-Zhi Wang*, Yisheng Lu*, Basal Forebrain Cholinergic Innervation Induces Depression-Like Behaviors Through Ventral Subiculum Hyperactivation, Neuroscience Bulletin, 2022,doi: 10.1007/s12264-022-00962-2. (* corresponding author)

[12]Hualing Peng, Jie Jia, Yisheng Lu*, Hua Zheng*, Isoflurane Rescue Schizophrenia-Related Deficits through Parvalbumin-Positive Neurons in the Dentate Gyrus, Biomedicines, 2022, 10(11):2759. doi: 10.3390/biomedicines10112759. (* corresponding author)

[13]Guangpin Chu, Hualing Peng, Nana Yu, Yuejin Zhang, Xueling Lin, Yisheng Lu*, Involvement of POMC neurons in LEAP2 regulation of food intake and body weight, Frontiers in Endocrinology, 2022, eCollection, doi:10.3389/fendo.2022.932761. (* corresponding author)

[14]Hong Zhou, Jiayu Zhu, Jie Jia, Wei Xiang, Hualing Peng, Yuejin Zhang, Bo Liu*, Yangling Mu*, Yisheng Lu*, The antidepressant effect of nucleus accumbens deep brain stimulation is mediated by parvalbumin-positive interneurons in the dorsal dentate gyrus, Neurobiology of Stress, 2022, 21:100492. doi:10.1016/j.ynstr.2022.100492.(* corresponding author)

[15]Zhuo Chen, Susu Pan, Kaili Yin, Yuejin Zhang, Xiaoman Yuan, Sihan Wang, Shujuan Yang, Qing Shen, Yizhe Tang, Juxue Li, Youjun Wang, Yisheng Lu*, Guo Zhang*,Deficiency of ER Ca²⁺sensor STIM1 in AgRP neurons confers protection against dietary obesity, Cell Reports 2021, 37(3):109868. doi: 10.1016/j.celrep.2021.109868. (* corresponding author)

[16]Yandong Yi, Yuanlong Song*,Yisheng Lu*, Parvalbumin Interneuron Activation-Dependent Adult Hippocampal Neurogenesis Is Required for Treadmill Running to Reverse Schizophrenia-Like Phenotypes,Front Cell Dev Biol. 2020, 8(24): eCollection. (* corresponding author)

[17]Ji H. So, Chao Huang, Minyan Ge, Guangyao Cai, Lanqiu Zhang,Yisheng Luand Yangling Mu, Intense Exercise Promotes Adult Hippocampal Neurogenesis But Not Spatial Discrimination,Front Cell Neurosci. 2017, 11(13): eCollection

[18]Haitao Wu, Arnab Barik,Yisheng Lu, Chengyong Shen, Andrew Bowman, Lei Li, Anupama Sathyamurthy, Thiri W. Lin, Wen Cheng Xiong, Lin Mei, Slit2 as a β-catenin/ctnnb1-dependent retrograde signal for presynaptic differentiation,elife2015, 4: e07266

[19]Yisheng Lu*, Xiangdong Sun*, Feng-Qing Hou, Lin-Lin Bi, Dong-Min Yin, Fang Liu, Yong-Jun Chen, Jonathan Bean, Hui-Feng Jiao, Xihui Liu, Bao-Ming Li, Wen-Cheng Xiong, Tian-Ming Gao and Lin Mei, Maintenance of GABAergic activity by neuregulin 1-ErbB4 in amygdala for fear memory,Neuron2014, 84 (4): 835-846. (*: equal contribution)

[20]Lin-Lin Bi, Xiang-Dong Sun, Jie Zhang,Yi-Sheng Lu, Yi-Hua Chen, Jue Wang, Fang Liu, Meng Zhang, Fei Geng, Ji-Hong Liu, Lin Mei and Tian-Ming Gao, Amygdala NRG1-ErbB4 is critical for the modulation of anxiety-like behaviors,Neuropsychopharmacology.2015, 40, 974–986

[21]Arnab Barik*,Yisheng Lu*, Anupama Sathyamurthy, Andrew Bowman, Chengyong Shen, Wen-cheng Xiong, Lin Mei, LRP4 is critical for neuromuscular junction maintenance,Journal of Neuroscience. 2014, 34 (42):13892-13905. (*: equal contribution)

[22]Chengyong Shen*,Yisheng Lu*, Bin Zhang*, Dwight Figueiredo‎, Haitao Wu, Barik Arnab, Wen-Cheng Xiong, Lin Mei, Antibodies against low-density lipoprotein receptor–related protein 4 induce myasthenia gravis,J. Clin. Invest.2013, 123 (12), 5190-5202. (*: equal contribution)

[23]Dong-Min Yin*, Yong-Jun Chen*,Yi-Sheng Lu, Jonathan C Bean, Anupama Sathyamurthy, Chengyong Shen, Xihui Liu, Clifford Smith, Wen-Cheng Xiong and Lin Mei, Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1,Neuron. 2013, 78 (4), 644-657. (*: equal contribution)

[24]Haitao Wu,Yisheng Lu, Chengyong Shen, Neil Patel, Lin Gan, Wen C. Xiong, Lin Mei, Distinct Roles of Muscle and Motoneuron LRP4 in Neuromuscular Junction Formation,Neuron.2012, 75 (1), 94-107.

[25]Haitao Wu*,Yisheng Lu*, Arnab Barik, Anish Joseph, Mark Makoto Taketo, Wen-Cheng Xiong, Lin Mei. β-Catenin gain of function in muscles impairs neuromuscular junction formation.Development. 2012, 139(13), 2392-2404 (*: equal contribution).

[26]Yong-Jun Chen, Meng Zhang, Dong-Min Yin, Lei Wen, Annie Ting, Pu Wang,Yi-Sheng Lu, Xin-Hong Zhu, Shu-Ji Li, Cui-Ying Wu, Xue-Ming Wang, Cary Lai, Wen-Cheng Xiong, Lin Mei, Tian-Ming Gao. ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation.Proc. Natl. Acad. Sci. 2010, 107 (50), 21818-21823

[27]Lei Wen*,Yi-Sheng Lu*, Xin-Hong Zhu*, Xiao-Ming Li, Ran-Sook Woo, Yong-Jun Chen, Dong-Min Yin, Cary Lai, Alvin V. Terry Jr., Almira Vazdarjanova, Wen-Cheng Xiong, Lin Mei. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons.Proc. Natl. Acad. Sci. 2010, 107 (3): 1211-1216 (*: equal contribution)

[28]Yisheng Lu*, Yubing Lv*, Yihong Ye, Yalin Wang, Yu Hong, Mark E. Fortini, Yi Zhong, Zuoping Xie. A role for presenilin in post stress regulation: Effects of presenilin mutations on Ca2+ currents in Drosophila,FASEB J. 2007, 21: 2368-2378 (*: equal contribution)

[29]Yubing Lu*,Yi-Sheng Lu*, Yichun Shuai, Chunhua Feng, Tim Tully, Zuoping Xie, Yi Zhong, Hai-Meng Zhou. The AKAP Yu is required for olfactory long-term memory formation in Drosophila,Proc. Natl. Acad. Sci. 2007, 104 (34): 13792-13797 (*: equal contribution)