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刘平

作者: 时间:2019-01-01 点击量:

刘平,华中科技大学基础医学院研究员、博士生导师。入选湖北省“百人计划”。现任Frontiers in Molecular Neuroscience编委。担任湖北省生物物理学会理事、湖北省病理生理学会理事、武汉病理生理学会理事。主持国家自然基金面上项目、华中科技大学“交叉研究支持计划”。2008年在华中科技大学生命科学与技术学院生化与分子生物学专业取得博士学位。2008年-2014年在美国康涅狄格大学医学院(University of Connecticut Health)神经生物学系做博士后研究。2014年-2018年在该系担任研究助理。2019年任康涅狄格大学医学院讲师。2019年9月入职华中科技大学基础医学院,病理生理学系。

联系邮箱:pingl@hust.edu.cn

研究方向

主要以秀丽线虫(C. elegans)和小鼠为模式动物研究:

1.动物行为、学习与记忆的神经环路和突触机制。

2.神经-免疫互作。

发表论文

#Co-first author*Corresponding author

1.Zhan, X., Chen, C., Niu, L., Du, X., Lei, Y., Dan, R., Wang, Z.-W., andLiu, P.*(2023). Locomotion modulates olfactory learning through proprioception in C. elegans. Nature Communications 14, 4534. 10.1038/s41467-023-40286-x.

2.Mueller, B.D., Merrill, S.A., Watanabe, S.,Liu, P., Niu, L.-G., Singh, A., Maldonado-Catala, P., Cherry, A., Rich, M.S., Silva, M., et al. (2023). CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles. eLife 12, e81407. 10.7554/eLife.81407.

3.Li, X., Chen, C., Zhan, X., Li, B., Zhang, Z., Li, S., Xie, Y., Song, X., Shen, Y., Liu, J.,Liu, P*, Liu, G*, Yang, X*. (2021). R13 preserves motor performance in SOD1G93A mice by improving mitochondrial function. Theranostics 11, 7294-7307. 10.7150/thno.56070.

4.Shui, Y.,Liu, P., Zhan, H., Chen, B., and Wang, Z.W. (2020). Molecular basis of junctional current rectification at an electrical synapse. Sci Adv 6, eabb3076. 10.1126/sciadv.abb3076.

5.Niu, L.G.,Liu, P., Wang, Z.W., and Chen, B.J. (2020). Slo2 potassium channel function depends on RNA editing-regulated expression of a SCYL1 protein. Elife 9. ARTN e5398610.7754/eLife.53986.

6.Niu, L.G., Li, Y., Zong, P.Y.,Liu, P., Shui, Y., Chen, B.J., and Wang, Z.W. (2020). Melatonin promotes sleep by activating the BK channel in C. elegans. P Natl Acad Sci USA 117, 25128-25137. 10.1073/pnas.2010928117.

7.Liu, P.#, Chen, B., and Wang, Z.W. (2020). GABAergic motor neurons bias locomotor decision-making in C. elegans. Nature Communications 11, 5076. 10.1038/s41467-020-18893-9.

8.Liu, P.#, Wang, S.J., Wang, Z.W., and Chen, B.J. (2018). HRPU-2, a Homolog of Mammalian hnRNP U, Regulates Synaptic Transmission by Controlling the Expression of SLO-2 Potassium Channel in Caenorhabditis elegans. Journal of Neuroscience 38, 1073-1084. 10.1523/Jneurosci.1991-17.2017.

9.Hawk, J.D., Calvo, A.C.,Liu, P., Almoril-Porras, A., Aljobeh, A., Torruella-Suarez, M.L., Ren, I., Cook, N., Greenwood, J., Luo, L., et al. (2018). Integration of Plasticity Mechanisms within a Single Sensory Neuron of C. elegans Actuates a Memory. Neuron 97, 356-367 e354. 10.1016/j.neuron.2017.12.027.

10.Niu, L.G.,Liu, P., Shui, Y., Mailler, R., Wang, Z.W., and Chen, B. (2017). BKIP-1, an auxiliary subunit critical to SLO-1 function, inhibits SLO-2 potassium channel in vivo. Sci Rep 7, 17843. 10.1038/s41598-017-18052-z.

11.Liu, P.#, Chen, B., Mailler, R., and Wang, Z.W. (2017). Antidromic-rectifying gap junctions amplify chemical transmission at functionally mixed electrical-chemical synapses. Nature Communications 8, 14818. 10.1038/ncomms14818.

12.Chen, B.,Liu, P., Hujber, E.J., Li, Y., Jorgensen, E.M., and Wang, Z.W. (2017). AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor. Nature Communications 8, 1380. 10.1038/s41467-017-01704-z.

13.Boisvert, E.M., Engle, S.J., Hallowell, S.E.,Liu, P., Wang, Z.W., and Li, X.J. (2015). The Specification and Maturation of Nociceptive Neurons from Human Embryonic Stem Cells. Sci Rep 5, 16821. 10.1038/srep16821.

14.Liu, P.#, Chen, B., and Wang, Z.W. (2014). SLO-2 potassium channel is an important regulator of neurotransmitter release in Caenorhabditis elegans. Nature Communications 5, 5155. 10.1038/ncomms6155.

15.Liu, P.#, Chen, B., and Wang, Z.W. (2013). Postsynaptic current bursts instruct action potential firing at a graded synapse. Nature Communications 4, 1911. 10.1038/ncomms2925.

16.Liu, P.#, Chen, B., Altun, Z.F., Gross, M.J., Shan, A., Schuman, B., Hall, D.H., and Wang, Z.W. (2013). Six innexins contribute to electrical coupling of C. elegans body-wall muscle. PLoS One 8, e76877. 10.1371/journal.pone.0076877.

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